Goal 2: Reduce Human Disease

Addressing low-level-evidence in cardiovascular guidelines

There is a need for the NHLBI to systematically assess CV guidelines that have public health importance and that can be addressed by pragmatic, government-funded trials.

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Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

A much greater proportion of CV guidelines which dictate practice standards would be based on high-quality scientific evidence.

Feasibility and challenges of addressing this CQ or CC :

Guidelines are already written and levels of evidence are already assessed (by others). Methods for conducting pragmatic trials exist (e.g. embedding in registries, leveraging digital resources, recognizing the importance of pragmatic trials within the clinical community).

More than 85% of active CV guideline are based on less than level 1A evidence.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Idea No. 179