Goal 2: Reduce Human Disease

Psychological & Behavioral Phenotyping to Improve Weight Control

What information is needed to improve our understanding of individual characteristics and processes that explain or predict dietary intake patterns, initiation or sustained engagement in physical activity, and sedentary behavior so that we can improve treatment matching and identify novel targets for more efficacious individual- and population-level approaches for weight management?

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Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Because there is wide variability in response to obesity treatment, strategies that take individual psychological, behavioral, sociocultural, motivational, cognitive and emotional characteristics into account so that treatments can better "match" the individual's needs could greatly improve the efficacy of existing treatments and/or lead to new more effective weight loss strategies.

Feasibility and challenges of addressing this CQ or CC :

By adding measures of key psychological, social, and behavioral processes to ongoing or planned weight control studies, we can learn which characteristics are most predictive of weight loss and maintenance for which participants, leading to better tailoring of weight loss treatments to the individual and potentially improved outcomes.

Despite evidence that use of evidence-based behavioral weight loss strategies can be effective and lead to meaningful improvements in health outcomes, there is wide variability in response to treatment and varying degrees of maintenance of weight loss.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Idea No. 224