Goal 1: Promote Human Health

Hypothermia and hemostasis after severe trauma

There is a need to employ new molecular tools to delineate the difference between beneficial and uncontrolled shock-induced hypothermia, because data on hypothermia and hemostasis are incomplete or lacking, especially on the duration, depth and type of hypothermia.

 

availability of targeted resource grant funding

Tags (Keywords associated with the idea)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

improvement of survival with life threatening traumatic injuries with new metabolically modulating strategies, including "simple hypothermia", improved understanding of the relationship between ischemia and reperfusion, the role of inflammatory and metabolic pathways, definition and identification of appropriate targets for therapy, the role for mechanical devices, and relationship between timely application of hypothermia and rewarming.

Feasibility and challenges of addressing this CQ or CC :

the tools and animal models are available to study hemostatic and metabolic modulation/hypothermia in traumatic injury

Trauma is the major cause of death in young individuals in the US, and globally, with uncontrolled hemorrhage representing the major cause of preventable deaths. Hypothermia, used in life threatening cardiovascular states, also holds enormous promise for application in traumatic injuries. Early deployment (pre-hospital) of novel protective metabolically modulating strategies to attenuate cellular injury from shock and reperfusion, such as hypothermia could be beneficial. However, the relationship between hypothermia in traumatic setting is complex, with data suggesting detrimental outcomes if it occurred spontaneously. In contrast, hypothermia induced in a controlled manner can protect tissues from ischemic injury.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Idea No. 251