Much of the current clinical research on sleep and circadian research depends on cohorts designed for other purposes. While this has been helpful, such studies have limitations. These limitations are related to availability of in-depth phenotyping data and questions as to whether individuals identified in population studies are equivalent to those who present clinically with specific disorders. These concerns could be overcome by developing registries of patients with different sleep disorders and development of a cohort that has as its primary focus sleep and circadian disorders.
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