(@nma120)

Goal 2: Reduce Human Disease

Understanding of chronobiological systems

We know that all life functions are based on circadian and other rhythms; chronobiological systems are interdependent in intricate ways. Disturbances and disorders in one part of a system may affect other vital systems in unexpected but far-reaching ways. Many aspects of circadian rhythms and sleep-wake regulation in normal, healthy humans have been charted. Much of the knowledge thus gained is assumed to be valid also ...more »

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1 net vote
1 up votes
0 down votes
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(@teitelbaum)

Goal 4: Develop Workforce and Resources

Align PhD Content with Careers Available to Recent PhDs

There is a need to create better alignment between the content of biomedical PhD programs and the careers that actually are available to those who have earned PhDs. Though available data are surprisingly weak, all the evidence suggests that only a small fraction (perhaps 15%) of current biomedical PhDs and postdocs are likely to find stable careers in academic research. Larger proportions are more likely to be employed ...more »

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4 net votes
14 up votes
10 down votes
Active
(@nhlbiforumadministrator1)

Goal 3: Advance Translational Research

Improving blood supply by giving a pig a human bone marrow transplant from a universal donor

What do you think of giving a pig a human bone marrow transplant from a universal donor? The pig could produce blood for human use! Although the pig will eventual die of an autoimmune disease its life can be prolonged with all the new autoimmune medicines we have and/or the pig can be engineered to overexpress PDL1 (or a similar autoimmune suppressor). Additionally even if each pint of blood made this way might be ...more »

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-26 net votes
11 up votes
37 down votes
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(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Increased receptivity to probative programmatic trials

We believe there should be greater openness to large, simple trials that answer clear questions of interest (e.g. does giving children more fruits and vegetables while changing nothing else lead to weight loss?; does eating breakfast regularly lead to weight loss?; etc.). The conduct of such trials may sometimes be expensive but can sometimes be only modestly costly if they are kept simple. However, it is difficult to ...more »

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0 net votes
1 up votes
1 down votes
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(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Longitudinal Outcomes in Adults with Congenital Heart Disease

There is a critical need in congenital heart disease to assess longitudinal medical and psychosocial outcomes in older children and adults in the U.S. Current data in this area, particularly in the adult population, is limited to single center or small multicenter efforts or registry/population data from other countries. Understanding the long-term aspects of care is necessary not only to provide lifelong high quality ...more »

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11 net votes
15 up votes
4 down votes
Active
(@stacey.rentschler)

Goal 3: Advance Translational Research

Translational Cardiovascular Medicine

There is a need for the NHLBI to catalyze the development of tools and shared data resources to facilitate mechanistic studies in a human model system. This includes the ability to culture human cardiac tissue, as well as generate a resource to systematically characterize and catalog the epigenome and histone marks associated with the transcriptome in normal and diseased heart tissues.

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6 net votes
10 up votes
4 down votes
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(@nhlbiforumadministrator1)

Goal 3: Advance Translational Research

Integrated Clinical Guideline on Comorbidities in Primary Care

The development of systematic evidence reviews (SER) that provide the evidence that partner organizations can use to develop an integrated clinical practice guideline for use by primary care providers for the treatment of patients with single and multiple conditions for the primary and secondary prevention of heart, lung, blood, and sleep (heart, lung, blood, sleep) diseases.

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1 net vote
12 up votes
11 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Multilevel and stepped-care approaches to improving adherence

What are successful multilevel combinations of strategies (involving patients, providers and the health care system) and/or stepped-care approaches (tailoring adherence interventions to patient needs) that can be used to improve adherence to behavioral and medical regimens for heart, lung, blood, sleep diseases and disorders?

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12 net votes
24 up votes
12 down votes
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(@media0)

Goal 4: Develop Workforce and Resources

Funding & Review Mechanisms

Funding and review mechanisms are essential resources that can facilitate or hinder innovative research to meet the NHLBI goals. These resources must be refocused to result in identification and funding of the type of innovative research being sought by NHLBI. The opportunities for leveraging available NHLBI funds with other sources should be considered formally as a component of overall budget planning, not just on ...more »

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4 net votes
8 up votes
4 down votes
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(@apollia112)

Goal 1: Promote Human Health

How common is Omega 3 nutritional deficiency, and how can people make sure they're getting enough Omega 3?

If I understand correctly what I've read, it may be tough to get enough Omega 3 because Omega 3 & Omega 6 compete with each other & many people consume much more Omega 6 than Omega 3. http://www.drweil.com/drw/u/QAA400149/balancing-omega-3-and-omega-6.html I fear the situation might be even worse for vegetarians, because from what I've read, it appears much easier to get the DHA & EPA forms of Omega 3 from animal sources. ...more »

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-5 net votes
3 up votes
8 down votes
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