Goal 2: Reduce Human Disease

Testing PCSK9 Inhibitors

Several inhibitors of PCSK9 are in phase 3 development and show considerable promise for improving the lipid profile; they will be especially appropriate for patients with Familial Hypercholesterolemia and those with statin intolerance. The sponsoring pharmaceutical companies need to complete CVD endpoint trials with full safety testing. However, there may well be more than one drug approved for marketing. The sponsors ...more »

Submitted by (@stephen.fortmann)

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Goal 2: Reduce Human Disease

Pathogenesis and treatment of cardiovascular disease in survivors of critical illness.

Acute cardiovascular complications are frequent in critical illness and injury, occurring on a spectrum that includes troponin leak or demand ischemia to acute occlusive coronary events and lethal arrhythmias. They arise in the course of similar acute illnesses but they epidemiology, pathogenesis, treatment and long-term consequences are unknown. Are they the result of a generalized inflammatory state that persists ...more »

Submitted by (@greg.martin)

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Goal 3: Advance Translational Research

Better disease models

Many diseases of the heart, lung and blood systems are studied using animal models, often with genetically engineered mice. However, while mice get models, humans get diseases. Too many grants are devoted to curing models, a practice encouraged by many high profile journals who want to see “proof” in a standard model of disease. Much less time, effort and money will be wasted on developing ineffective therapies if focus ...more »

Submitted by (@nhlbiforumadministrator)

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126 up votes
29 down votes
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Goal 3: Advance Translational Research

Do Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis Inform COPD? Have we been looking?

Cystic fibrosis (CF) and alpha-1 antitrypsin deficiency (AATD) share phenotypic features with common COPD including airflow obstruction and airway mucociliary dysfunction. Although research in CF and AATD has advanced our understanding of those rare diseases, it has yet to explain common COPD. Do Alpha-1 Antitrypsin Deficiency and Cystic Fibrosis Inform COPD? Could therapies currently in use or under development for ...more »

Submitted by (@kerickson)

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24 up votes
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Goal 3: Advance Translational Research

Xenotransplantation is the future and ideal treatment for end stage organ failure

A genetically engineered and humanized pig organ expressing human genes and devoid of antigens immunogenic to humans may prove to be an ideal solution to overcome the acute organ shortage for solid organ transplantation. Recently, a remarkable progress has been made in this direction with reports of graft survival approaching 3 yrs in a pig to primate cardiac transplantation model.The issues of viral transmission and ...more »

Submitted by (@mmohiud2)

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20 net votes
29 up votes
9 down votes
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Goal 4: Develop Workforce and Resources

Loss of the middle years

The challenge I write about is the significant lack of funding for science in NHLBI. There are currently programs to increase the funding of early career investigators and many senior faculty are obtaining continuing renewal.

How will NHLBI keep those in their middle of their career years from dropping out of the biomedical workforce?

Submitted by (@nhlbiforumadministrator)

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102 up votes
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Goal 1: Promote Human Health

Reporting disaggregated data by sex

There is a need to better understand the biological basis for sex differences, particularly for identifying important basic factors that influence normal cardiovascular function and cardiovascular disease in males or females and explain differences in the overall prevalence, progression, and mechanism of cardiovascular disease.

Submitted by (@nhlbiforumadministrator)

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8 net votes
13 up votes
5 down votes
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Goal 2: Reduce Human Disease

Recognition of bicuspid aortic valve's complexity, life threatening potential, and familial implications.

There is a persistent perception that bicuspid aortic valve (BAV), the most common congenital heart defect (estimated to occur in up to 6 million Americans), is a benign condition that may not require treatment until later in life, if at all. The implications for other blood relatives, although referenced in medical literature, may not be acknowledged. This notion, coupled with the inability to identify those most at ...more »

Submitted by (@bavtad)

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Goal 1: Promote Human Health

Transformative Impact of Proteomics

The proteomics field has dramatically progressed over the past 20 years, with advancements and improvements in experimental designs and sample preparation protocols, as well as mass spectrometry equipment, approaches, and analysis. This has resulted in substantial forward progress towards a proteomic pipeline to establish cause and effect mechanisms of cardiovascular disease. There is a need for CV proteomics that resolve ...more »

Submitted by (@mllindsey)

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196 net votes
234 up votes
38 down votes
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Goal 2: Reduce Human Disease

Shift from NHLBI guided research to individual investigator initiative

NHLBI directed research should be abandoned and switched to investigator initiated research. I respectfully suggest read the following assay by Brown and Goldstein, Science 2012; 338: 1033-1034 The best way to run the science sponsored by the NIH (or NHLBI) is not to guide it (analogy to running science from ivory tower) but let the investigators decide what is worth pursuing. Get rid of NHLBI-directed research initiative ...more »

Submitted by (@nhlbiforumadministrator)

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