(@nhlbiforumadministrator)

Goal 4: Develop Workforce and Resources

Improving Biomedical Careers

There is a critical challenge to retain highly trained basic and clinical scientists in the biomedical research enterprise and expediently promote their independence and capacity to produce innovative discoveries. There is a need to provide more funding opportunities for collaborative, team-science approaches to scientific investigation by interdisciplinary teams comprised of clinician scientists, basic researchers, and... more »

Voting

32 net votes
50 up votes
18 down votes
Active
(@dburand)

Goal 1: Promote Human Health

Using video to replace the boring highly ineffective drug monographs that accompany prescrptions

Estimates are that less than 2% of medication monographs are actually read by patients. Of those 2% only 35% fully comprehend the material. Why not use video and simpler methods to educate patients about their medicine. By coding QR tags to direct patients to education websites, we solve the drive through phenomena, the health literacy issue, and the language barrier.

Voting

-12 net votes
4 up votes
16 down votes
Active
(@lvanhorn)

Goal 2: Reduce Human Disease

What is the role of diet and nutrition in treatment, management and prevention of Heart Failure?

Heart Failure (HF) remains a major public health burden. A working group was convened by NHLBI and ODS in June, 2013 to address the role of diet and nutrition in management of HF. A review of existing evidence produced no clear rationale for appropriate dietary interventions. On the contrary, the group developed recommendations for conducting additional research specifically on the role of sodium, fluid, nutrients, and... more »

Voting

2 net votes
3 up votes
1 down votes
Active
(@ghunninghake)

Goal 2: Reduce Human Disease

Identifying Early Stages of Pulmonary Fibrosis

The majority of translational research designed to improve the lives of patients with pulmonary fibrosis has focused on studies of patients with advanced fibrotic lung disease. In contrast, little effort has been paid to understanding the natural history of pulmonary fibrosis, exploring the mechanisms/pathogenesis of the development of pulmonary fibrosis, and considering work designed to prevent the development of lung... more »

Voting

29 net votes
35 up votes
6 down votes
Active
(@elaine)

Goal 2: Reduce Human Disease

The Use of Therapeutic Apheresis to Reduce Circulating Levels of Galectin-3 and other Cancer and Inflammation Promoting Factors

Inflammation plays roles in cancer initiation, promotion, and progression. Elevated circulating galectin-3 (Gal-3) protein and other cancer and inflammation promoting factors (CIPFs) such as C-reactive protein and VEGF are associated with tumorigenesis and may play causative roles. Plasma Gal-3 is a biomarker, prognosticator, and pathogenic mediator of diverse cancers and is emerging as a therapeutic target. Preliminary... more »

Voting

33 net votes
40 up votes
7 down votes
Active
(@jennifergrobinson)

Goal 2: Reduce Human Disease

How can we implement what we already know for ASCVD prevention?

We have a number of highly effective evidence-based interventions that have been shown to reduce ASCVD events - statins, BP drugs, aspirin, acute care. Yet large proportions of high risk population groups are not taking evidence-based treatment. Numerous interventions have been tried at multiple levels from the individual patient to the federal government payors. What are the best practices? How can we systematically... more »

Voting

-9 net votes
3 up votes
12 down votes
Active
(@teitelbaum)

Goal 4: Develop Workforce and Resources

Moderating Positive Feedback between Research Funding and PhD/postdoc Numbers

A critical challenge will be to limit future destabilizing expansion of the number of PhD students and postdoc trainees. Because 75-80% of biomedical PhD students and postdocs now supported by NIH are funded by RO1 and other research funding, if/when research grant budget increase the number of PhD and postdoc “slots” would automatically expand--even if there is no expectation of comparable increases in demand for... more »

Voting

5 net votes
15 up votes
10 down votes
Active
(@jnoel0)

Goal 1: Promote Human Health

DESIGN AND EVALUATE INTERVENTION STRATEGIES TO IMPROVE SLEEP HEALTH AND CIRCADIAN DISRUPTION

Data indicate the association between short sleep and circadian disruption on a number of adverse outcomes such as cardiovascular disease, metabolic disorders, hypertension, etc. There is a need to move beyond association to interventions that can be shown to improve sleep duration and circadian disruption.

Voting

205 net votes
250 up votes
45 down votes
Active
(@tantillo)

Goal 1: Promote Human Health

Promoting health through simultaneous prevention of obesity and eating disorders

How to best promote healthy weight while also not stigmatizing obesity and creating risk for eating disorders (i.e., weight concern and body dissatisfaction) in youth. How to tackle both without contributing in unwitting way to development of either.

Voting

62 net votes
116 up votes
54 down votes
Active