Strategic Goal: Goal 4: Develop Workforce and Resources

Safeguarding Mentorship for the Next Generation

There is a need to ensure that mentors have adequate skills, time, and incentives to mentor successfully.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Continuity of research discoveries requires that outstanding mentors impart their passion and research skills to the next generation. Opportunities and incentives must be provided to ensure that highly qualified scientists can devote adequate time and effort to mentor promising junior colleagues, as well as enhance their own research output.

Feasibility and challenges of addressing this CQ or CC :

Mentor-directed opportunities can be immediately made available to provide protected time and salary for scientists with a passion for mentoring.

The current K24 mechanisms have been shown to be quite beneficial, not only for the mentor who can advance his career in the academe, but more so for the trainees who are exposed to the science that the mentor brings. However, K24 awards are primarily for patient-oriented research which enhance clinical skills. Non-clinical biomedical research will also benefit from similar programs.

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138 net votes
168 up votes
30 down votes
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Strategic Goal: Goal 2: Reduce Human Disease

Anti-angiogentics in pulmonary hypertension

Would anti-angiogenic therapeutics prevent patients with pulmonary hypertension from worsening?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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38 net votes
52 up votes
14 down votes
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Strategic Goal: Goal 3: Advance Translational Research

EMR virtual registries for rare diseases

Rare disease suffer from poorly organized or unfunded networks of researchers and clinicians. Define cross-platform minimal datasets for EMRs using collaborative grants for researchers and EMR companies

Submitted by (@jhagood)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

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1 net vote
8 up votes
7 down votes
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Strategic Goal: Goal 2: Reduce Human Disease

mechansisms of post thrombotic syndrome

No good medical therapy exists to prevent and treat post thrombotic syndrome, the most common sequlae from a deep vein thrombosis. Recent trial data suggests that compression stockings do not prevent PTS, and thrombolysis is expensive and risky. The basic mechanisms related to fibrosis of the vein wall are not well understood.

Submitted by (@henke0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Further research into this area, both at the human and animal model level would allow potential translation of novel agents without the risks of anticoagulatnts, as well as shine light on basic fibrotic vascular disease processes.

Feasibility and challenges of addressing this CQ or CC :

Doable with both well defined human patients, and animal models of the disease that are similar to humans

Name of idea submitter and other team members who worked on this idea : peter henke

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1 net vote
5 up votes
4 down votes
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Strategic Goal: Goal 3: Advance Translational Research

Recognizing that HLB are components of a whole person

RASopathies is one of a group of syndromes that include heart, lung and blood issues, but these are not all the concerns. Recognizing that these organs are part of a functional network (called the human body), partnering with other Institutes could help expedite knowledge of these systems. Leveraging small pockets of funds through mechanisms such as R13 grants where the primary institution is not NHLBI is an inexpensive ...more »

Submitted by (@lschoyer)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Feasibility and challenges of addressing this CQ or CC :

Not hard, no cost.

Name of idea submitter and other team members who worked on this idea : Lisa Schoyer, President, RASopathies Network USA

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1 net vote
1 up votes
0 down votes
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Strategic Goal: Goal 3: Advance Translational Research

lipidomics

Although lipidomics research is a growing field of major importance for human health, I have not seen any grant opportunities where it is a focus. This is particularly the case for human/translational research. For example, although some metabolites of fatty acids have been shown in basic science research to be 1000 times more beneficial health than the fatty acids themselves, why is there what appears to be little interest? ...more »

Submitted by (@robertblock)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Such research can expand the implications of personalized medicine

Feasibility and challenges of addressing this CQ or CC :

There are many potential laboratory challenges but they can largely be overcome in the future with improved methods and technologies.

Name of idea submitter and other team members who worked on this idea : Robert C. Block, MD, MPH

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2 net votes
5 up votes
3 down votes
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Strategic Goal: Goal 2: Reduce Human Disease

Therapy for Heart Failure with Preserved Ejection Fraction

Are existing neurohormonal antagonist drugs effective in HFPEF ?

Submitted by (@lars.lund)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

HFPEF is as serious as HFREF and as many forms of cancer. But there is no therapy. Generic neurohormonal antagonist drugs are effective in HFREF and have potential in HFPEF. They will not be studied by industry and trials need public funding.

Feasibility and challenges of addressing this CQ or CC :

The challenge is streamlined efficient trials. This can be addressed with the registry-randomized trial concept.

Name of idea submitter and other team members who worked on this idea : Lars H. Lund

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-6 net votes
7 up votes
13 down votes
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Strategic Goal: Goal 2: Reduce Human Disease

Blood Donor and Component Factors that Influence Clinical Outcomes of Transfusion

Are donor factors (age/sex), whole blood processing methods and/or red cell storage solutions associated with in-hospital mortality and/or other measures of transfusion efficacy or harm in patients who have received red cell transfusions?

Submitted by (@anne.eder)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

There is growing evidence that donor factors (age, race-ethnicity, and/or sex), method of whole blood processing, and/or the additive solution used for red cell storage could affect the quality of the red cell product and contribute to patient adverse events. For example, red cell rigidity and oxygen saturation varies between premenopausal women and postmenopausal women and men, suggesting that donor age and/or sex may be important factors affecting red cell quality and patient outcomes. A retrospective Canadian study suggested that older blood was associated with in-hospital mortality until 2006; however, after that time the risk of in-hospital mortality increased when fresher blood was transfused. This change coincided with introduction of the buffy coat method suggesting that whole blood processing methods may affect patient outcomes.

Feasibility and challenges of addressing this CQ or CC :

The most efficient way to explore these issues is through the use of large dataset that can link donor demographics, product processing and recipient transfusion and outcome data. Recipient datasets are available and the feasibility of linking blood donor and blood product information has been demonstrated, making it possible to address the research question stated above.

Name of idea submitter and other team members who worked on this idea : Dana Devine PhD and Anne Eder MD PhD for the 2015 NHLBI State of the Science in Transfusion Medicine

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24 net votes
34 up votes
10 down votes
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Strategic Goal: Goal 2: Reduce Human Disease

Pediatric and Adult Heart Failure

How does the mechanism of pediatric heart failure differ from adult heart failure mechanisms?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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1 net vote
13 up votes
12 down votes
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Strategic Goal: Goal 2: Reduce Human Disease

Smartphone medical apps

A great potential benefit exists for the use of smartphone medical apps for medical doctors, patients, and trainees. NHLBI may help support to test and/or develop smartphone apps in clinical studies and medical training.

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Facilitating and improving patient care, medical staff training, cost-saving, etc.

Feasibility and challenges of addressing this CQ or CC :

Wide use of smartphones and fast technology development.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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30 net votes
54 up votes
24 down votes
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Strategic Goal: Goal 4: Develop Workforce and Resources

Suipport new research using the R21 mechanism

The decision by NHLBI to not support the R21 mechanism may be stifling new and innovative research, partcularly by young investigators who do not have a track record of R01 funding. The critical challenge is to keep funding new ideas from younger investigators to keep their careers viable while they obtain the data and publications necessary for further R01-level funding.

Submitted by (@georgeporter)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

The state of NHLBI funding rates for R01s are so low that we are undoubtedly loosing many young researchers as the fail to obtain adequate support for their research. Funding R21 grants will allow new, innovative, and perhps risky projects to proceed, while keeping less established researchers in the field. Re-establishing R21 funding may prevent the impression that NHLBI is more interested in supporting established labs and not advocating for and supporting new investigators.

Feasibility and challenges of addressing this CQ or CC :

Given the limited budget of R21s, they will not have as large an impact on the overall budget of NHLBI as the equivalent number of funded R01 grants. Therefore, this change is feasible from a financial standpoint. Obviously, funding R21s will decrease funding for other mechanisms. Finally, it is possible that many of these grants will not lead to advances in the field, but it is my understanding that studies show the same thing about R01s.

Name of idea submitter and other team members who worked on this idea : George Porter

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87 net votes
101 up votes
14 down votes
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Strategic Goal: Goal 3: Advance Translational Research

Improving heart, lung, blood, sleep Health Outcomes for Minority and Underserved Men

What are the best strategies to improve implementation of evidence-based practices (EBP) to enhance effective health risk communication strategies among racial and ethnic minority males and underserved men? Examples of several issues that need to be addressed are: • Need for better definition of the role of families/communities in EBP (as co-therapists). • Requires less system fragmentation • Need for improved measurement, ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Our improved ability to develop, implement and disseminate EBPs tailored specifically for men in health disparity populations may help us move beyond current obstacles in addressing health inequities and improve health outcomes.

Some current challenges:

• High blood pressure affects more than 40 percent of African Americans.

• The odds for stroke, the third leading cause of death in the United States, are especially high for African American men at 70%.

• African Americans are about 50% more likely to experience stroke than Caucasians.

• Sleep apnea is seen more frequent among men than among women, particularly among African-American and Hispanic men.

• Life expectancy for African American men is 4.7 years less than for white men (2010).

• Native American men have an average life expectancy of 71 years old compared to white men who have an average life expectancy of 76.5 year.

Feasibility and challenges of addressing this CQ or CC :

• Shifting demographics of race as well as ageing of the population in this country will have a major impact on the utilization, organization and delivery of health care.

• Country acknowledges significant economic burden of health inequities in the U.S. in the near future.

• Hospitals and health systems are working hard to align quality improvement goals with disparities solutions. Opportunity to leverage these efforts for the development and implementation of targeted health disparities initiatives is timely.

• HL has a number of large population-based studies (such as JHS, Strong Heart, Hispanic Community Health) that could be leveraged to specifically identify EBP for wider implementation and dissemination to underserved areas.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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14 net votes
32 up votes
18 down votes
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