Goal 3: Advance Translational Research

Submitted by (@greg.martin)

Durable gene activity map at the individual level

A durable gene activity map of the individual to understand when certain gene sets are on vs off or dysfunctional over an individual’s lifetime as one way of guiding the precision of medicine for that patient. It would need to be person portable and universally exportable and interpretable across all of the EHRs.

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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

Glycans are critical for mammalian biology at a fundamental level

There is a pervasive view of glycobiology as a niche field that does not warrant significant attention. This is borne out of a profound ignorance. It is not an exaggeration to state that carbohydrates are just as important as proteins, nucleic acids, and lipids. Dismissing the impact of glycans is like stating that proteins are not very important to biology, and their importance is seen in the lethality of many mutations ...more »

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Goal 3: Advance Translational Research

Submitted by (@athomas4)

Culturally Specific Preventative research

There are ample research evidence related factors contributing to obesity,type 2 diabetes, cardiovascular disease.The research grant money is diverted heavily on "novel" topic such as genes.The preventative efforts are the key to tackle the issues.Often times,researchers on cardiovascular prevention find it difficult to add novel ideas to convince the grant reviewers in their application.There are many communities here ...more »

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Goal 2: Reduce Human Disease

Submitted by (@bcelli)

COPD and co-morbidities

Society is ageing and chronic degenerative diseases including COPD are increasingly occurring together. The critical question is whether certain diseases occur together by chance or are they occurring together because they share pathobiological commonalities and mechanisms? This leads to a series of practical consequences and questions 1. Which diseases are occurring concurrent with COPD more than chance alone would ...more »

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Goal 2: Reduce Human Disease

Submitted by (@greg.martin)

Effect of obesity on recovery of lung function in pediatric survivors of critical illness

What are the determinants of persistent respiratory failure in children? Are obese children at greater risk for prolonged mechanical ventilation than non-obese children? Does BMI affect the time to recovery of lung function in obese children with ARDS? What is the pathogenesis and molecular contributors of obesity on respiratory failure in critical illness?

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

A Systems Approach to Obesity

There is a need to use an integrated systems approach to obesity prevention and treatment. Obesity is a complex phenotype influenced by factors from the molecular to the socio-economic level. To address the causes and prevention of obesity, we need to integrate information at the molecular level with behavioral, social and environmental data. This will require investigators in molecular biology, genetics, epidemiology, ...more »

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