Goal 1: Promote Human Health

Role of non-coding RNAs in cardiovascular biology and disease

Noncoding RNAs field is still in its infancy. It includes microRNA and long-non-coding RNA. Recent studies show that Non-coding RNA play important roles in the regulation of tissue homeostasis and pathophysiological conditions. miRNA-based therapeutics showed promising results in numerous animal models of heart failure, cardiac hypertrophy, fibrosis and hyperlipidaemias, and showed success in in-human clinical trial ...more »

Submitted by (@totaryjainh)

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Goal 2: Reduce Human Disease

Inflammation: what is the role of the blood microbiome?

Blood is not continuously sterile. Data from dental studies, blood donors, and random blood cultures document that "normal" human blood often harbors microbes. Sepsis only occurs when immunological regulatory systems fail. Growing evidence link subclinical, potentially transient bacteremia to cardiovascular and other diseases. Could many of the diseases associated with inflammatory markers represent either continuous ...more »

Submitted by (@kevinfiscella)

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Goal 2: Reduce Human Disease

Conduct a clinical trial whether maximizing melatonin using orange eyeglasses in the evning reduces breast cancer.

Epidemiological studies have shown totally blind women have about half the incidence of breast cancer as blind women who retain light control of melatonin suppression or of women with normal vision. Studies show shift worker that reduces melatonin and disrupts the circadian rhythm increases the risk of breast cancer. Studies show human breast cancer grafts grown on rats but supplied with human blood grow rapidly if the ...more »

Submitted by (@rhansler)

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Goal 3: Advance Translational Research

Next generation of cellular blood products for clinical use

What advancements in our understanding of hematopoietic stem cell differentiation can be combined with practical developments in novel processing and storage technologies to develop the next generation of transfused blood therapeutics? There is a dearth of tools to evaluate the efficacy of transfused blood products, although this is the most commonly employed therapeutic procedure in the US. There is also no financial ...more »

Submitted by (@nhlbiforumadministrator)

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