Approach, diagnostics and management of asthma-COPD overlap syndrome.
What does early COPD actually look like. This is defined as severe COPD 30 years prior to its manifestation.
Integrated healthcare strategies during transitions in COPD care
• What is cost effectiveness of multi-component COPD programs?
• Will early admission to a Pulmonary Rehabilitation program following a hospitalization for COPD reduce the likelihood of readmission within the following year?
• What is the most effective time to implement the transition from hospitalization following a COPD exacerbation admission?
Society is ageing and chronic degenerative diseases including COPD are increasingly occurring together. The critical question is whether certain diseases occur together by chance or are they occurring together because they share pathobiological commonalities and mechanisms? This leads to a series of practical consequences and questions 1. Which diseases are occurring concurrent with COPD more than chance alone would ...more »
What is the comparative effectiveness of prescribing continuous LTOT in COPD that targets fixed oxygen flow rates vs. oxygen saturation on patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations)?
Disease modifying COPD therapy
a. Should we be starting therapy earlier in the course of disease?
b. Is there a survival benefit of oxygen therapy for exercise-induced hypoxemia?
Can normoxemic patients with COPD benefit from oxygen supplementation?
Medical marijuana and COPD
What is the impact of screening for depression on outcomes of patients with COPD?
What is the pathogenesis and appropriate treatment for subjects with chronic respiratory symptoms or imaging abnormalities who do not have overt airflow obstruction (and thus are not currently categorized as having COPD)?
What is the comparative effectiveness of a Non-invasive vs. Invasive Positive Pressure
Ventilation Protocol for managing acute respiratory failure due to acute exacerbations of COPD
What barriers and facilitators modify the effectiveness of smoking cessation programs in patients with COPD?
COPD hospitalizations a. Define the pathobiological changes that lead to severe exacerbations that cause hospitalizations b. Define novel clinical and biological phenotypic characterizations of hospitalized patients who fail treatment that results in death or early readmission c. Explore new or understudied therapies for treatment of acute COPD hospitalizations: antioxidant, non-steroidal anti-inflammatory (STATIN or ...more »
What are the risk factors for sleep-disordered breathing in patients with COPD (the “overlap syndrome")?