(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Lung Repair and Regeneration

What characteristics define progenitor lung cell niches? What controls proliferation and differentiation of lung progenitor cells in normal repair? Can endogenous repair mechanisms and alterations of progenitor cell cycle be harnessed to promote regeneration?

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10 net votes
22 up votes
12 down votes
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(@john.alcorn)

Goal 2: Reduce Human Disease

Impact of Successive Acute Lung Injury on Subsequent Challenge

A great deal of focus has been placed on understanding chronic lung diseases such as asthma and CF. Long term changes in inflammatory and epithelial processes are well documented in this area. However, less research has addressed the impact of successive pulmonary injuries and how these seemingly acute events shape the lung response. This is the crux of the multi-hit theory regarding interstitial lung disease. Many acute ...more »

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-10 net votes
4 up votes
14 down votes
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(@rft2106)

Goal 2: Reduce Human Disease

What are the molecular mechanisms of lung injury, and how do they differ in children?

Both adults and children have significant morbidity and mortality due to lung injury, but have different etiologies and outcomes. It is possible that the underlying pathobiology in the two groups is different. There are no targeted therapies for lung injury, indicating that the cause is still not understood.

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4 net votes
4 up votes
0 down votes
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(@chenx106)

Goal 2: Reduce Human Disease

Impact of lung remodeling on congestive heart failure progression

End stage congestive heart failure (CHF) causes intensive lung remodeling beyond the type-2 pulmonary hypertension. CHF induced lung remodeling includes profound lung fibrosis, lung vascular remodeling and lung inflammation. Understanding CHF-induced lung remodeling is also critical to understand the right ventricular failure. However, this area is largely unstudied. Regulating CHF-induced lung remodeling and the underlying ...more »

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13 net votes
15 up votes
2 down votes
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(@gcosgrove)

Goal 2: Reduce Human Disease

Fibrosis Care Center Network and Patient Registry

Complex diseases such as interstitial lung disease and pulmonary fibrosis requires a collaborative effort to effectively characterize, appropriately diagnose, and efficient evaluate novel therapies. Similarly, basic, translational and clinical research in this field requires the integration of clinical phenotypes with biologic specimens. We propose the expanded development of the Care Center Network and Patient Registry ...more »

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2 net votes
2 up votes
0 down votes
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(@chrisbonafide)

Goal 3: Advance Translational Research

What are the most effective strategies for reducing alarm fatigue and optimizing cardiorespiratory monitor alarm management?

Hospital cardiorespiratory monitors have great potential to save lives, but are hampered by high false alarm rates that contribute to alarm fatigue. While the long term solution is developing new medical devices that will do this better, few hospitals will benefit from new device innovations in the next decade. In order to better identify early signs of cardiorespiratory deterioration in the hospital at an early stage ...more »

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-6 net votes
4 up votes
10 down votes
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