(@breathinglady)

Goal 2: Reduce Human Disease

Use Buteyko breath retraining to help patients manage and monitor their lung condition.

Buteyko Breath Retraining has been verified by the AHQR, Thorax Journal and other organizations as a legitimate technique to improve the symptoms of asthma and related respiratory illness. This simple technique could be instituted for a low cost to improve the quality of life of patients, reduce medications necessary for good control and save taxpayers and insurance companies a great deal of money.

Voting

-15 net votes
1 up votes
16 down votes
Active
(@escalante.patricio)

Goal 4: Develop Workforce and Resources

Shall we increase the transparency of the grant review process to prevent potential biases?

Financial and intellectual conflict(s) of interest are common in academic medical sciences. Those conflicts could potentially bias decisions of study section members and change grant application outcomes. During the grant review process, financial and/or intellectual conflict(s) of interest disclosures of the study section members are not readily available to the grant applicants or the public. Should the NHBI increase ...more »

Voting

18 net votes
24 up votes
6 down votes
Active
(@societyforvascularsurgery)

Goal 2: Reduce Human Disease

Data from regulatory studies a barrier to evidence-based medicine

Alignment of regulatory, healthcare, and research arms of the government is poor. There is a need to improve the design, quality and usefulness of data from regulatory studies to address major clinical questions and also to facilitate scientific inquiry. This is a barrier to evidence based medicine and improved treatments.

Voting

2 net votes
3 up votes
1 down votes
Active
(@dayam0)

Goal 2: Reduce Human Disease

Does epinephrine improve outcomes in OHCA

Epinephrine is the primary drug that is used in resuscitation but observational studies and a few small RCT suggest that it improves short term but not long term outcomes. Factors such as timing, dose, quality fo CPR and post-resuscitation care all confound the issue. Large RCTs conducted at multiple centers are desperately needed to address this question.

Voting

1 net vote
3 up votes
2 down votes
Active
(@scottsimon)

Goal 3: Advance Translational Research

Detection of inflammatory monocytes as a biomarker of CVD

Coronary artery disease (CAD), of which atherosclerosis is a major contributor, costs the United States $108.9 billion each year. While a number of conventional risk factors such as smoking, diabetes and hypertension have been associated with CAD, their predictive performance is poor in the prevention of acute coronary syndrome (ACS). Despite the prevalence of ACS in our society, there are currently no molecular biomarkers ...more »

Voting

-6 net votes
8 up votes
14 down votes
Active
(@k.willard)

Goal 3: Advance Translational Research

Palliative and hospice care for COPD patients

Does palliative care and/or hospice care as practiced across communities improve end-of-life care for COPD – specifically, does it reduce the burden of symptoms, improve HRQoL and satisfaction, reduce utilization in last 6 months of life (i.e. hospital visits, cost, invasive ventilation use, etc), improve the end-of-life experience, and increase the concordance of place of death to expressed patient preferences?

Voting

12 net votes
16 up votes
4 down votes
Active
(@glancast)

Goal 1: Promote Human Health

Updating level C evidence in Clinical Guidelines

Clinical Guidelines depends on good science. Despite this, only 11% of guidelines that reported level of evidence in 2009, had level of evidence A while 48% had level C. Studies have shown that recommendations based on Level of Evidence C (or their equivalence) are significantly less reliable and may be downgraded, reversed or omitted when better evidence is available. I propose a comprehensive review of ACC/AHA ...more »

Voting

3 net votes
3 up votes
0 down votes
Active
(@mariannes.clancy)

Goal 2: Reduce Human Disease

What is the effect of variant genes on AVM development in HHT

Natural genetic variation between individuals can influence the outcome of carrying an HHT mutation. Some gene variants may be protective while others may increase the risk of AVM or telangiectasis. By identifying the variant genes that alter risk of AVM may give clues to the molecular mechanisms of AVM formation and provide new drug targets

Voting

1 net vote
1 up votes
0 down votes
Active
(@pandrea)

Goal 2: Reduce Human Disease

Interactions between anticoagulant therapy and antiretroviral drugs

Cardiovascular pathology has become a major problem in the management of the HIV-infected patient during the ART era. A large number of HIV patients will receive anticoagulants drugs for secondary prevention of cardiovascular disease. It is therefore critical to understand the interactions between antiretroviral therapy and anticoagulant therapy to safely treat HIV patients.

Voting

2 net votes
5 up votes
3 down votes
Active
(@sjk000)

Goal 1: Promote Human Health

Theoretical division of NHLBI

Many functional physiology, cellular physiology , electrophysiology, and other aspects are amenable to rigorous mathematical methods.NHLBI lacks a theoretical division where IDEAS expressed mathematically make testable predictions at multi scale levels. NHLBI LACKS A THEORETICAL DIVISION- although history has shown that virtually all original ideas have a mathematically expressible foundation, particularly when dynamic, ...more »

Voting

-13 net votes
12 up votes
25 down votes
Active