Goal 3: Advance Translational Research

What is the comparative effectiveness of short-term vs. chronic (e.g., 12 mo) pulmonary rehabilitation?

What is the comparative effectiveness of short-term vs. chronic (e.g. 12 mos) pulmonary rehabilitation on survival, patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations), healthcare utilization, and costs from a societal and healthcare system perspective?

Submitted by (@jakris)

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26 net votes
32 up votes
6 down votes
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Goal 2: Reduce Human Disease

Cardiovascular risk and adverse event prediction & estimating net benefit in statin-treated individuals

Compelling Question: There is insufficient data to personalize the use of nonstatin or other preventive therapies in statin-treated patients. Equations could then be developed to predict CVD risk and to predict the risk of adverse events in statin-treated patients to guide intensification of therapy.

Submitted by (@jennifergrobinson)

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3 net votes
11 up votes
8 down votes
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Goal 1: Promote Human Health

Studying Health in Addition to Disease

Why do some people stop smoking after a stroke or myocardial infarction, whereas others do not? What motivates people who adopt a healthier diet and exercise program during their lifetime or after a significant health event? How can we promote healthier lifestyle choices at all stages of life? How do we ensure equitable health promoting activities for minorities, vulnerable populations, and lower socio-economic status ...more »

Submitted by (@nhlbiforumadministrator1)

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135 net votes
176 up votes
41 down votes
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Goal 4: Develop Workforce and Resources

Moderating Positive Feedback between Research Funding and PhD/postdoc Numbers

A critical challenge will be to limit future destabilizing expansion of the number of PhD students and postdoc trainees. Because 75-80% of biomedical PhD students and postdocs now supported by NIH are funded by RO1 and other research funding, if/when research grant budget increase the number of PhD and postdoc “slots” would automatically expand--even if there is no expectation of comparable increases in demand for ...more »

Submitted by (@teitelbaum)

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5 net votes
15 up votes
10 down votes
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Goal 3: Advance Translational Research

Comprehensive Assessment of Cardiovascular Physiology: Imaging of Structure, Function and Blood Flow

The development of cardiovascular disease is associated with changes in structure, function and blood flow within a complex and highly interconnected system. Current diagnostic tools focus on individual elements of the cardiovascular system and/or relatively simple parameters which do not reflect the true underlying pathophysiology. A novel multi-modular and multi-parametric approach based on new and promising imaging ...more »

Submitted by (@mmarkl)

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1 net vote
1 up votes
0 down votes
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Goal 2: Reduce Human Disease

Contribution of non-lipid factors to atherosclerotic vascular disease

Despite the generally accepted thesis linking lipids to atherosclerosis, a large number of patients fail to benefit from statins, the current lipid-lowering drugs of choice. Moreover statins are reported to cause diabetes and severe muscle weakness in some patients thus adding to the general conundrum associated with statin therapy. This prompts an important, yet unresolved question related to non-lipid factors contributing ...more »

Submitted by (@priyaraman)

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9 net votes
13 up votes
4 down votes
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Goal 2: Reduce Human Disease

Funding for Hemostasis & Thrombosis Research

Thrombotic disorders, a result of the inappropriate activation of the hemostatic system, remain major causes of morbidity and mortality in the United States. Cancer, cardiovascular disease, trauma, and many of the other causes of death in the U.S. frequently culminate in a fatal thrombotic event. Notably, thromboembolic disease affects 500,000 people annually and leads to 100,000 deaths in the United States alone. Current ...more »

Submitted by (@abrams)

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128 net votes
136 up votes
8 down votes
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Goal 3: Advance Translational Research

Developing Curative Approaches to Cardiovascular Disease rather than Chronic Magement

Most Pharmacological interventions in cardiovascular diseases tend to address to be used in palliative manner and chronically. There is urgent need for treatments that are curative. This goes to identifying molecular drivers of the diseases and targeting them to correct the underlying pathophysiology rather than symptom suppression.

Submitted by (@john.buolamwini)

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1 net vote
2 up votes
1 down votes
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Goal 3: Advance Translational Research

facilitate journal submissions by creating a common submission template

To increase the efficiency of getting timely findings published and to decrease the administrative busywork of learning formatting requirements of each journal for each new submission and of reformatting manuscripts for submission to a new journal. Although this may only take a day or 2 to do, multiplied by thousands of investigators and by all their publications each year this administrative time adds up and takes away ...more »

Submitted by (@lindapeterson)

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1 net vote
7 up votes
6 down votes
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