Goal 1: Promote Human Health

Submitted by (@jlaakso)

Examining the interface between physiological and pathophysiological angiogenesis and placental function in at risk pregnancies.

Abnormal placental function, characterized by retarded nutrient and oxygen exchange, and abnormal hormone and angiogenic growth factor production, is linked to a number of diseases that have a strong impact on maternal and fetal health. Perhaps of highest impact is pre-eclampsia, a disease affecting 5-8% of pregnant women worldwide. Moreover, issues related to a suboptimal intrauterine environment leading to growth ...more »

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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

What is the role of the environment in HLB disease etiology

It is clear that genetic sequence variation does not account for a substantial portion of disease burden. It is likely that the broad environment contributes to HLB disease via epigenomic alterations and interaction with genetic variants. There is an urgent need to understand the environmental contribution to disease as most exposures are modifiable and are targets for prevention interventions.

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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

Continuous blood pressure and outcomes monitoring

Currently technology exists for continuous, non-invasive, insertable (not breaking any skin), blood pressure monitoring. At the same time micro-vascular health and whole body inflammatory response can be monitored continuously. The challenge is for the integration of these technologies into a simple device so we can begin to produce long term data on genetic and environmental influences on outcomes.

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Goal 1: Promote Human Health

Submitted by (@apollia112)

How common is Omega 3 nutritional deficiency, and how can people make sure they're getting enough Omega 3?

If I understand correctly what I've read, it may be tough to get enough Omega 3 because Omega 3 & Omega 6 compete with each other & many people consume much more Omega 6 than Omega 3. http://www.drweil.com/drw/u/QAA400149/balancing-omega-3-and-omega-6.html I fear the situation might be even worse for vegetarians, because from what I've read, it appears much easier to get the DHA & EPA forms of Omega 3 from animal sources. ...more »

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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

NIH should promote, rather than deter “fast-track” translational research projects

In the current environment, NIH reviewers actually deter, rather than promote, progress on proposed pre-clinical animal research that is most likely to rapidly translate into clinical breakthroughs in the short term. Scientists should be allowed to focus on critical missing information (roadblocks) needed to accelerate a promising treatment to clinical trials. For instance, at the NHLBI there is currently no study section ...more »

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Goal 3: Advance Translational Research

Submitted by (@lindapeterson)

facilitate journal submissions by creating a common submission template

To increase the efficiency of getting timely findings published and to decrease the administrative busywork of learning formatting requirements of each journal for each new submission and of reformatting manuscripts for submission to a new journal. Although this may only take a day or 2 to do, multiplied by thousands of investigators and by all their publications each year this administrative time adds up and takes away ...more »

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