Goal 2: Reduce Human Disease

Submitted by (@fbogun)

Cardiac Sarcoidosis

There is a fundamental gap in our knowledge about many aspects of cardiac sarcoidosis. Isolated cardiac involvement poses a particular challenge for diagnosis. Delay in establishing the correct diagnosis can be long and impacts in outcome since delay in therapy adversely impacts on outcome in these patients. There should be an increased effort to increase our knowledge about cardiac sarcoidosis; it's natural history, ...more »

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Goal 3: Advance Translational Research

Submitted by (@daniel.perez)

Develop guidelines, standard of care, new technologies for respiratory care for adult facioscapulohumeral muscular dystrophy

There is a need for NHLBI to develop guidelines, standard of care, new technologies for respiratory care for adult muscular dystrophy (facioscapulohumeral, myotonic and limb girdle) patients with undiagnosed or unforeseen hypercarbia CO2 retention in the acute setting who end up in trouble to help the families, doctors and patients navigate their way back to stable condition e.g. perhaps going forward with non-invasive ...more »

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Goal 2: Reduce Human Disease

Submitted by (@dayam0)

Benefits of intraosseous access on outcomes from OHCA

Vascular access is a challenge in the setting of out-of-hospital cardiac arrest (OHCA). The failure of medications to impact outcomes may be in part related to the delay in drug delivery from the IV route. EMS systems have adopted intraosseous (IO) access but it is not clear if these are affecting outcome and there has been no large RCT. The current IO access devices are expensive and use different routes (sternal, tibia, ...more »

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Goal 3: Advance Translational Research

Submitted by (@nadkarni)

What is the optimal way to improve cardiac arrest resuscitation?

Sudden Death from cardiac arrest and gaps in knowledge of emergency cardiovascular care are the #1 killer of more than 400,000 Americans each year. This epidemic of death and disability is largely ignored and underfunded by NIH and all funding agencies and kills more than HIV, Cancer, Diabetes, and infectious diseases. There is no national registry of cardiac arrest, no mandatory reporting, and poor funding for both fundamental, ...more »

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Goal 2: Reduce Human Disease

Submitted by (@greg.martin)

Consequences of drug interactions leading to QTc prolongation

Better understand the consequences of drug interactions leading to QTc prolongation. About 1/3 of cardiac ICU patients develop QT prolongation and about 45% receive drugs that are possibly contributing to this problem. The full spectrum of contributors and causes, as well as the patient-centered and health-system-centered clinical outcomes, are not known.

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