Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator1)

The Investigator's Catch-22: How Can NHLBI Help?

The Critical Challenge is to determine how NHLBI can continue to foster the translational research necessary to allow our researchers to further develop their NHLBI-funded basic science discoveries. Researchers can't readily get a "typical" grant to perform the preclinical and early clinical translational IND-enabling research, and also can't yet attract private sector support without having done the work to "de-risk" ...more »

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10 net votes
21 up votes
11 down votes
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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Basic Research for HIV/AIDS and HLB Health and Diseases

What HIV/AIDS-related basic research can NHLBI support in the next 5-10 years to investigate the fundamental mechanisms of HIV-related heart, lung, and/or blood (HLB) diseases alone and in the context of antiretroviral therapy (ART) to improve heart, lung, and blood health outcomes in HIV infections as well as the fundamental mechanisms of hematopoietic stem cell transplantation in potential elimination or eradication ...more »

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-22 net votes
14 up votes
36 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Culturally competent T4 research interventions to reduce heart, lung, blood, sleep

Using previous federal and partner infrastructure, what are the best methods to promote culturally competent T4 interventions that will reduce cardiopulmonary risk factors in global populations with a disproportionate burden of heart, lung, blood, sleep diseases?

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-7 net votes
9 up votes
16 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@fblei0)

Develop Vascular Anomalies Medical Training and Research Programs

Patients with vascular anomalies frequently see many physicians and undergo extraneous tests with incorrect diagnoses. A major reason for this is due to the fact that medical training does not include Vascular Anomalies in the syllabus. Thus, many specialties erroneously use the term "hemangioma" for any vascular diagnosis. Over the past 2 decades, there have been major breakthroughs in basic and genetic research, as ...more »

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-1 net votes
7 up votes
8 down votes
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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

leveraging EHR through improved partnerships

Large medical delivery systems have an abundance of information stored in their EHR systems. What steps are necessary to develop partnerships between NHLBI and medical delivery systems or other agencies such as AHRQ to access these EHR systems, develop a common terminology (if icd 9 and other common codes are ineffective for merging data) and add that data to dbGap for NIH/community use?

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1 net vote
13 up votes
12 down votes
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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Clinical Research for HIV/AIDS and HLB Health and Diseases

What HIV/AIDS-related clinical research can NHLBI support in the next 5-10 years on the prevention, diagnosis, and treatment of HIV-related heart, lung, and/or blood (HLB) diseases in adults and children to improve heart, lung, and blood health outcomes in HIV infections?

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-19 net votes
14 up votes
33 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@parise)

R01 funding

Unless we fix and increase the R01 funding rate, which most basic scientists depend upon, we will continue to lose outstanding scientists of all ages and not have the next generation of scientists or the numbers of currently outstanding scientists to answer any of these compelling questions and critical challenges. Related to this, much has been written about the significant failure rate of clinical trials in part due ...more »

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420 net votes
435 up votes
15 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator1)

Expand the H3Africa Partnership Model to Decrease HLB diseases

Is there a way to decrease the risks for HLB disease leveraging the H3Africa genomics platform? • Leverage partnerships providing resources to the H3African populations • Identify the best collaborative partners to reach out to the low resource population • Find the best mechanism for collaborations to facilitate the interventions in low resource settings • Merge NHLBI research objectives and goals with those of potential ...more »

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-6 net votes
6 up votes
12 down votes
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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Harnessing the ongoing ‘natural experiments’ of quality improvement

How do we harness the ongoing “natural experiments” of quality improvement (QI) activities in various healthcare systems to facilitate hypothesis-driven research, improve scientific validity to address questions in clinical trials, and implement and disseminate research results? • Current restrictions in human subjects research regulations • Diversity in approaches and methodology rigor to QI initiatives across different ...more »

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-2 net votes
11 up votes
13 down votes
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Goal 2: Reduce Human Disease

Submitted by (@hongw0)

Mechanism and target identification for cardiovascular disease using database mining and experimental strategies

The big database of -omics and noncoding RNAs provide a valuable search engine to establish the link of various disease conditions with pathways and molecules. During recent year, data mining of available biomedical data and information has merged for target discovery and mechanism identification. However, current database mining research remains limited and largely hypothetical. Comprehensive research using the combinatory ...more »

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19 net votes
26 up votes
7 down votes
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