(@wjones7)

Goal 4: Develop Workforce and Resources

Making R01 funding work for the Medical Sciences

We need to spread R01 funding around more to ensure that the best science has funding adequate to move forward. To do this I believe changing how we think about R01 funding and expenditures can be used to put the NIH funds to better use. Too often successful researchers have the majority of their salaries on R01s and the institutions have little skin in the game. PI salaries can be a large part of the escalating budget... more »

Voting

28 net votes
44 up votes
16 down votes
Active
(@bavtad)

Goal 2: Reduce Human Disease

Recognition of bicuspid aortic valve's complexity, life threatening potential, and familial implications.

There is a persistent perception that bicuspid aortic valve (BAV), the most common congenital heart defect (estimated to occur in up to 6 million Americans), is a benign condition that may not require treatment until later in life, if at all. The implications for other blood relatives, although referenced in medical literature, may not be acknowledged. This notion, coupled with the inability to identify those most at... more »

Voting

1 net vote
12 up votes
11 down votes
Active
(@mnicolls)

Goal 3: Advance Translational Research

Developing animal models of lung transplantation.

Lung transplantation as a cure for terminal lung disease has seen little improvement in outcomes for more than 20 years. The field remains highly challenging, in part, because of an absence of robust animal models which are technically- feasible and reproducible across centers. Further, models have limited relevance to clinical (chronic) airway remodeling, the leading problem in pulmonary allografts. In the absence of... more »

Voting

5 net votes
15 up votes
10 down votes
Active
(@juliewashko)

Goal 2: Reduce Human Disease

Assess the true impact of sickle cell trait on cardiovascular health across then age spectrum

Sickle cell disease is now understood as a disease of inflammation in addition to abnormal red blood cells. It is likely persons with sickle cell trait are also negatively affected by the damage caused by inflammation. There is a significant racial disparity in hypertension, stroke, and chronic kidney disease. It remains unclear the degree to which sickle cell trait contributes to this disparity. It also remains unclear... more »

Voting

17 net votes
31 up votes
14 down votes
Active
(@baz200)

Goal 1: Promote Human Health

Obesity and Morbid obesity

Obesity is a pervasive disease. It contributes to serious diseases such as heart, all the way down to cancer. In the past five decades it has been confirmed that the sugar from rich carbohydrate (CHO) foods increases the production of insulin which in turn converts the excess caloric intake into fat. So far neither dieting with highly processed foods rich in CHO’s, nor radical surgery have made a dent in this most... more »

Voting

-1 net votes
4 up votes
5 down votes
Active
(@nhlbiforumadministrator1)

Goal 3: Advance Translational Research

Improving blood supply by giving a pig a human bone marrow transplant from a universal donor

What do you think of giving a pig a human bone marrow transplant from a universal donor? The pig could produce blood for human use! Although the pig will eventual die of an autoimmune disease its life can be prolonged with all the new autoimmune medicines we have and/or the pig can be engineered to overexpress PDL1 (or a similar autoimmune suppressor). Additionally even if each pint of blood made this way might be... more »

Voting

-26 net votes
11 up votes
37 down votes
Active