Goal 4: Develop Workforce and Resources

Strategic Visioning Initiative is just a beginning: it needs a mechanism for implementation

NHLBI Strategic Visioning Initiative is a good idea. You have received a score of useful suggestions from Academia and business. But like and good idea, it needs someone to follow through. Otherwise your new beautiful plans for cardiovascular research may die without a significant impact.

Submitted by (@soldatovn.humgenex)

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Goal 4: Develop Workforce and Resources

Training approaches in lymphatic biology

The lymphatic vascular network connects the parenchymal interstitium through the nodes to the veins. Lymph serves as the transport pathway between these compartments and via its flow, controls interstitial fluid, macromolecular exchange, lipid absorption, immune cell trafficking and is critical to edema prevention/resolution, lipid metabolism, inflammation and immunity. Knowledge of this vascular network lags far behind ...more »

Submitted by (@dcz000)

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Goal 4: Develop Workforce and Resources

Promoting Translational Research training using the R03 mechanism

We in Wisconsin have developed a robust training program for mixed MD and PhD postdocs in a clinical dept and yet their future in research is blocked by few faculty positions, poor funding and over complicated NIH applications. One of the simplest grants is the R03 and we have already had graduates with only a few years postdoc experience succeed in gaining R03 funding. The R03 is a very simple very flexible mechanism. ...more »

Submitted by (@ianbird)

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-1 net votes
10 up votes
11 down votes
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Goal 2: Reduce Human Disease

Innovations in Red Cell Transfusion in Sickle Cell Disease

Challenges that need to be overcome in blood transfusion, especially in SCD, include: a. Adopting molecular genotyping as the standard in blood transfusion therapy. b. Advancing new generation, anti-oxidant hemoglobin-based oxygen carriers (HBOCs) for use in emergencies such as trauma, stroke, acute hemolysis, and in transfusion in SCD and related disorders. In SCD, HBOCs have the capacity to not only serve as substitutes ...more »

Submitted by (@nhlbiforumadministrator1)

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29 net votes
47 up votes
18 down votes
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Goal 2: Reduce Human Disease

The role of Extracorporeal Photopheresis (ECP) in the prevention and treatment of rejection of heart and lung transplants

According to the ISHLT, more than 4,000 patients undergo a heart transplant each year, and almost 4,000 receive single or double lung transplants. Their prognosis depends heavily on the avoidance of rejection, which claims the majority of their lives. For heart transplant recipients, the median survival is 11 years, while for lung transplant recipients, it is approximately 5 years. The current most common anti-rejection ...more »

Submitted by (@mmarques)

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80 net votes
102 up votes
22 down votes
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Goal 1: Promote Human Health

Would unconditional basic income improve people's health & ease poverty better than conventional welfare programs?

Here's an article on the "Mincome" program which Canada tested in the 1970's in a small town: http://www.dominionpaper.ca/articles/4100 It had many positive effects on people's lives and health. Quotes: 'In the period that Mincome was administered, hospital visits dropped 8.5 per cent.' [...] '“When you walk around a hospital, it's pretty clear that a lot of the time what we're treating are the consequences of poverty,” ...more »

Submitted by (@apollia112)

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Goal 3: Advance Translational Research

Personalized Medicine thru CV bioinformation/tissue repository

There is a need to establish virtual CV biologic tissues and a bioinformational repository for specific CV diseases, including congenital cardiovascular malformations, genetic or other unique cardiomyopathies, such as stress cardiomyopathy and giant cell myocarditis.

Submitted by (@nhlbiforumadministrator1)

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-13 net votes
10 up votes
23 down votes
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Goal 2: Reduce Human Disease

Non-obstructive Coronary Disease

It is increasingly apparent that ischemic heart disease does not equal obstructive coronary disease. There is a large, heterogeneous population of individuals who present to the ED with chest pain syndrome with or without a troponin elevation, who on diagnostic evaluation have non-obstructive disease and who on prospective studies have increased risk for ACS and early mortality; other literature shows the same for coronary ...more »

Submitted by (@matthew.burg)

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52 up votes
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Goal 1: Promote Human Health

Role of the lymphatic system in heart, lung, blood, sleep health and diseases

What is the role of lymphatic system in normal function of the heart? Do dysfunctional lymphatics contribute to heart failure? Do lymphatics have a role in recovery after MI? It has been reported that lymphatic vasculature transport HDL during reverse cholesterol transfer. Do lymphatics have a role in atherosclerosis? What is the contribution of lymphatic system to asthma or COPD? Does the lymphatic system contribute ...more »

Submitted by (@nhlbiforumadministrator1)

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50 net votes
77 up votes
27 down votes
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