What is the effect of sleep disorders on child development? Specifically, how sleep apnea with intermittent hypoxia and or sleep deprivation alters the normal trajectory of maturation of brain regions controlling cognition, behavior and the cardiovascular system?
Goal 2: Reduce Human Disease
The cap on R01 research grants at $500,000 per year has not changed in over 20 years. In the current fiscal crisis for research it has become an immovable block to submitting intervention studies (randomized clinical trials on treatment). Routine advice from NIH staff is to not even try for a larger study. The cap applies to every year, so one can design a trial that costs less than $2.5 million but exceeds $500,000 in ...more »
What are the underlying dependencies (genomic, metabolic, disease) in individual donors that either accelerate or delay the changes to red blood cells during refrigerated storage? What methods of preparation might protect patients from the risks posed by the accelerated degradation of RBCs provided by "poor storers"? What characteristics of individual patients make them particularly vulnerable to transfusion of red ...more »
What approaches can utilize current knowledge on health literacy/health communications as a research development tool and/or strategy to enhance obesity prevention and treatment efforts?
Is FVC a valid surrogate for mortality in patients with idiopathic pulmonary disease?
What are systems-based approaches to better define disease endotypes and develop more effective therapies, especially in multiple chronic conditions?
What is nicotine addiction in the absence of other materials? What cues are associated with smoking? We would like to see brain reward studies in special populations. We are also interested in understanding possible reduced harm in people who use e-cigarettes in cessation attempts, and understanding whether e-cigs are a gateway to other risky behaviors for young people who are experimenting.
The limitations of 5-day 22˚ C storage significantly impacts platelet availability. It is critical that we develop new methods of collection, processing, storage to extend the storage time of platelets, and evaluate the use of whole blood. The attributes of these products must be understood to optimally alignment product attributes, clinical efficacy and safety with hemostatic needs in a variety of clinical states. Specifically, ...more »
Does treating sleep apnea benefit patients with obstructive lung disease?
How do we address health disparities especially in our most vulnerable populations, including children?
How can we develop new approaches to improve vascular healing and extend the long term benefits of vascular interventions for more patients?
What is the effect of coconut oil (high in saturated fat) on blood lipids and cardiovascular disease (CVD) risk?