Goal 2: Reduce Human Disease

To extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.

Goal 2: Reduce Human Disease

Submitted by (@hongw0)

2. Mechanism and target identification for abnormal epigenetic regulation in cardiovascular disease

Abnormal epigenetic modification has been implicated in human disease. Epigenetic therapy using nonspecific inhibitors for histone acetylation and DNA methylation has been proved effective in some cancer. However, because histone acetylation and DNA methylation are essential biochemical modification of life process, globally suppression on these process would have severe adverse effect. Identification of specific mechanism ...more »

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Goal 2: Reduce Human Disease

Submitted by (@gabrielegrunig)

New analysis methods for research using animal models

The idea that 'animal models can faithfully predict the outcomes in human clinical trials of new medicines and treatments' is highly compelling. However, due to differences (biological and non-biological) between humans and animals this goal can likely not be achieved. Not only are animals genetically different from humans, everything else is different too. Even if living quarters are shared (e.g. house pet animals), ...more »

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Goal 2: Reduce Human Disease

Submitted by (@lvanhorn)

What is the role of diet and nutrition in treatment, management and prevention of Heart Failure?

Heart Failure (HF) remains a major public health burden. A working group was convened by NHLBI and ODS in June, 2013 to address the role of diet and nutrition in management of HF. A review of existing evidence produced no clear rationale for appropriate dietary interventions. On the contrary, the group developed recommendations for conducting additional research specifically on the role of sodium, fluid, nutrients, and ...more »

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Goal 2: Reduce Human Disease

Submitted by (@cjoseph)

Consequences of ABO or Rh Type Specific versus Non-Type Specific Platelet Transfusions

What are the consequences, clinically and immunologically, of ABO or Rh type specific vs. non-type specific platelet transfusions? There is widely varying practice as to ABO and Rh matching of platelets for transfusion. Most studies demonstrate that use of ABO unmatched (non-identical) platelets are associated with increased 1) platelet refractoriness (small randomized trials), 2) red cell transfusion needs and hemolysis, ...more »

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Goal 2: Reduce Human Disease

Submitted by (@dstephens)

Promotion of human health and reduction of human disease

Congenital heart disease (CHD) is the most common birth defect and leading cause of defect-related infant mortality. With nearly 1 in 100 babies born annually with CHD, the needs of children and adults born with CHD are ongoing and costly. More focused research into CHD promotes human health and will result in a better quality of life, reduced premature death and lower healthcare costs.

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