Ventilating patients in the operating room constitutes the largest number of patients exposed to mechanical ventilation in this country and world wide [many millions of patients]. Postoperative pulmonary problems may, in part, due to the mechanical ventilation received in the OR. Yet, this cohort has never been systematically studied in terms of the effect of specific ventilatory patterns on postoperative outcomes. Data ...more »
Goal 2: Reduce Human Disease
There is a need for more enhanced pain research in order to help improve sickle cell disease patient outcomes and quality of life.
Does pulmonary rehabilitation or regular exercise improve outcomes in patients with PVD?
The Challenge is to make behavioral weight loss programs readily available to he many overweight and obese patients who need them. Behaivoral weight loss programs are effective in producing weight losses of 7-10% of initial body weight, which has been shown to have major beneficial effects on a number of diseases relevant to NHLBI--including hypertension and sleep apnea. However, at present, these programs are not widely ...more »
Are there biomarkers or phenotypic characteristics that will allow us to identify the patients with asthma who will experience a more rapid decline in lung function?
How do we identify new and more effective approaches to reduce the burden of venous disease and venous ulceration?
Disease modifying COPD therapy
a. Should we be starting therapy earlier in the course of disease?
b. Is there a survival benefit of oxygen therapy for exercise-induced hypoxemia?
Heart failure (HF) affects over 5 million American adults, and projected estimates show growth of this epidemic by 25% over the next 15 years as the population of the United States continues to age. Heart failure with preserved EF (HFpEF) encompasses 50% of all heart failure cases. Preclinical diastolic dysfunction (PDD) is defined as normal systolic function, moderate or severe diastolic dysfunction determined by Doppler ...more »
Independent R01 are the lifeblood for biomedical research in this country. Reducing funding through this mechanism threatens the long term security of the research community and will cause young talented scientists to choose other careers. When funding is limited NIH should employ any measures available to maintain R01 a reasonable level of funding. This could be done by reducing indirect costs, large institutional awards ...more »
BMP9 circulates in the blood and signals through the endothelial cell. IN the absence of Alk 1, such as in HHT, the vessels become over-active. The overactivity can be partially balanced by activation of a second signaling pathway: notch. Would targeting notch be a useful drug target to reverse AVM formation
Can we decrease maternal mortality and morbidity due to hemorrhage or thrombosis?