Goal 2: Reduce Human Disease

To extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.

Goal 2: Reduce Human Disease

Submitted by (@murry0)

Stem Cell Immunology

We now can create critical cell types like cardiomyocytes etc. from stem cells. Additionally, we are learning the rules of using these cells to rebuild tissues. A major gap in our knowledge relates to the immunobiology of these cells. Lessons from transplantation medicine are only partially applicable, because solid organs are more complex and likely more immunogenic than defined cell populations. How does the immune ...more »

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45 up votes
22 down votes
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Goal 2: Reduce Human Disease

Submitted by (@katherinek)

How can we non-invasively, but still accurately, measure blood pressure in the pulmonary arteries?

Pulmonary hypertension (PH) is a complex, progressive condition characterized by high blood pressure in the lungs. The gold standard for measuring pressures in the pulmonary arteries is a right heart catheterization, where a special catheter is guided through the right side of the heart and into the pulmonary artery, the main vessel carrying blood to the lungs. This measurement is essential, as it allows physicians and ...more »

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67 net votes
75 up votes
8 down votes
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Goal 2: Reduce Human Disease

Submitted by (@golan0)

Reducing Disparities

NHLBI should continue to support prospective cohort studies, projects, and investigators that evaluate longitudinal outcomes in minority populations where longitudinal data are scarce and difficult to obtain. The resources generated remain invaluable and can be used to conduct crosscutting translational research (i.e. the Jackson Heart Study, Strong Heart Study, and others).

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2 up votes
1 down votes
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Goal 2: Reduce Human Disease

Submitted by (@kendraz)

Sleep Paralysis must be better known to doctors, therapists, and the public

Sleep Paralysis (SP) is a very common (up to 40% of all people), yet little-known condition that is terrifying, and potentially traumatizing, especially to people who are unaware of this condition. It is critical that SP is better known by all doctors, therapists, and the public. Too many people are mistreated and misdiagnosed as psychotic or even demon possessed when they do not understand SP, or they hide the experience ...more »

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10 net votes
15 up votes
5 down votes
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