Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Multilevel and stepped-care approaches to improving adherence

What are successful multilevel combinations of strategies (involving patients, providers and the health care system) and/or stepped-care approaches (tailoring adherence interventions to patient needs) that can be used to improve adherence to behavioral and medical regimens for heart, lung, blood, sleep diseases and disorders?

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12 net votes
24 up votes
12 down votes
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(@dstephens)

Goal 3: Advance Translational Research

Advancing Translational Research

Ensuring that basic science is translated into clinical practice is essential. While there have been great strides in ensuring that babies born with congenital heart defects (CHD) are identified and repaired, we know that there are lifelong implications for those with CHDs that require continued follow-up and treatment. As the proportion of those with CHDs as adults continues to outpace the pediatric population, we urge ...more »

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2 net votes
4 up votes
2 down votes
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(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Facilitating the translation of discovery science into proof of concepts in preclinical models

What steps can the research community take to facilitate the translation of discovery science into proof of concepts in preclinical models and in humans for diagnosis, prevention, and treatment? • Current regulatory environment • Lack of communication between discovery and clinical research worlds • Lack of training • Getting industry, academia, and NHLBI to partner; and the business model to make it happen. • Limited ...more »

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17 net votes
25 up votes
8 down votes
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(@wjones7)

Goal 3: Advance Translational Research

pre-SBIR grant mechanism

SBIR STTR programs currently offer funds to support phase 1 and phase 2 development of translation with corporate involvement. Several here have pointed out that there is need for additional NIH support of investigator initiated translation, and I concur. There is indeed need for early stage and pre-IND support. Such a program would support relatively small grants for proof-of-principle studies, pre-clinical work needed ...more »

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-12 net votes
10 up votes
22 down votes
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(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Developing adherence research to reduce unnecessary mobility/mortality/cost

From Cochrane Review NOV 20 2014 RB Haynes “It is uncertain how medicine adherence can consistently be improved so that the full health benefits of medicines can be realized. We need more advanced methods for researching ways to improve medicine adherence, including better interventions, better ways of measuring adherence, and studies that include sufficient patients to draw conclusions on clinically important effects.” ...more »

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5 net votes
7 up votes
2 down votes
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(@teresabarnes)

Goal 3: Advance Translational Research

Sustainability and Continuation of Research

While many challenges to advancing research efforts exist, a particularly confounding one for patient advocates is when promising research efforts are funded by NHLBI and the research is completed and published (leading to more questions) and is seemingly forgotten. This lack of continuity leads to further questions and is absent a solid path forward applying what has been learned to next steps in the research effort. ...more »

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87 net votes
106 up votes
19 down votes
Active
(@hashmi.shahrukh)

Goal 3: Advance Translational Research

Don’t ask, don’t tell; the hidden costs of heart, lung & stem cell transplantation:Financial burden on transplant survivors

Thousands of patients get cured of their diseases with organ and/or hematopoietic stem cell transplantation (HSCT), but what happens after that to their social and financial life? Drug costs, multiple tests, travel to transplant centers, and many other factors cost a fortune to the patients (and their insurers). Can the NHLBI provide systems based approach longitudinally to alleviate the long term cost burden on patients ...more »

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25 net votes
42 up votes
17 down votes
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