Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.
(@marcozenati)

Goal 3: Advance Translational Research

Leverage Information Technology to Improve Patient Safety in Surgery

Progress toward a six-sigma level of safety (already achieved in commercial aviation) has been slow in medicine and surgery. The best cardiac surgery program operates at only 3.5 sigma level. In order to acceletate this process, it is critical to leveage recent advances in information technology, including but not limited to natural language processing (NLP), advanced speech recognition, artificial intelligence.

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-8 net votes
3 up votes
11 down votes
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(@jlombard)

Goal 3: Advance Translational Research

Direct Upregulation of Antioxidant Defenses as a Therapeutic Strategy

Clinical trials involving administration of antioxidants such as vitamin C or vitamin E as therapeutic strategies for cardiovascular diseases associated with oxidant stress have proven to be surprisingly disappointing. A particularly attractive alternative approach is direct upregulation of endogenous antioxidant defenses such as NRF2 via dietary approaches. NRF2 is a master antioxidant and cell protective transcription ...more »

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-5 net votes
2 up votes
7 down votes
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(@yanyunw)

Goal 3: Advance Translational Research

Study on the Immunologic Effects of ECP (Extracorporeal Photopheresis)

The clinical use of extracorporeal photopheresis (ECP) is expanding. It is known that dendritic cells plays critical role key to its efficacy, but exactly how ECP impacts other immune components and their interactions is not fully understood. There are many unanswered questions such as: “ What are the critical factors in ECP that result in a shift of the dendritic cell population from immune activating to immune tolerant? ...more »

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91 net votes
108 up votes
17 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Increased testing of new ideas

As indicated in two influential papers we have published, there are many potential contributing factors to obesity beyond those commonly discussed and studied and some of these are potentially modifiable. Increased research to understand whether these putative factors are really influential and whether they can be modified to produce benefits with respect to obesity are in order.

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0 net votes
1 up votes
1 down votes
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(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Inhaled antibiotics for patients with bronchiectasis

Many pharma companies are developing inhaled antibiotics for patients with bronchiectasis, recognizing the increasing market (over 110,000 patients in the US). These drugs cost thousands of dollars per year and will be heavily marketed and heavily used, as there are limited options for these patients. It is unknown if rotating oral antibiotics (cost is a fraction of the inhaled ABx) would yield similar results.  A Cochrane ...more »

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1 net vote
1 up votes
0 down votes
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(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Move beyond the use of self-report for dietary intake quantification

There is a need to move beyond the use of self-report for dietary intake quantification towards funding the development of new technology and broader use of objective measures. There is no question that the effects of diet on health, quality of life, and longevity are of great interest to many and plausibly of great importance. Because of that, tremendous research resources have been provided to study this topic. Given ...more »

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1 net vote
2 up votes
1 down votes
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(@nhlbiforumadministrator1)

Goal 3: Advance Translational Research

Research Opportunities in HLB to Facilitate Aging in Place

There is a need for greater evidence-based research over the next 5-10 years to reduce healthcare costs, reduce hospitalizations, and support older persons with significant heart, lung, blood, sleep conditions to remain in their private homes if feasible, if technology is utilized that fosters clinical and epidemiologic research.

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17 net votes
35 up votes
18 down votes
Active