Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.

Goal 3: Advance Translational Research

Submitted by (@scottsimon)

Detection of inflammatory monocytes as a biomarker of CVD

Coronary artery disease (CAD), of which atherosclerosis is a major contributor, costs the United States $108.9 billion each year. While a number of conventional risk factors such as smoking, diabetes and hypertension have been associated with CAD, their predictive performance is poor in the prevention of acute coronary syndrome (ACS). Despite the prevalence of ACS in our society, there are currently no molecular biomarkers ...more »

Voting

-6 net votes
8 up votes
14 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Greater reliance on stronger observational study designs when true RCTs are not an option

With some notable exceptions, the space in between OATs and pure RCEs is seen, at least in obesity research, as a void. Such a constrained view inappropriately lumps together valid evidence from strong, non-randomized designs with evidence from weak designs that permit little causal inference. There are additional methods occupying that intermediary space of strength of causal inference. If we can encourage the use of ...more »

Voting

1 net vote
2 up votes
1 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@sophpacz)

Maximizing anti-tumor immunity following allogeneic HCT with biomarkers

Allogeneic hematopoietic cell transplantation (allo-HCT) is one of the most effective forms of tumor immunotherapy available to date. Allo-HCT can be life-saving for patients with aggressive malignancies that cannot be cured through other strategies. The immunotherapeutic efficacy of allo-HCT depends on donor T cell recognition of alloantigens on leukemic cells, which is known as the graft-versus-tumor effect (GVT). No ...more »

Voting

32 net votes
52 up votes
20 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Point of care detection of rare cells in blood

Laboratory analyses at the bedside or in the hinterlands can reduce the cost and increase the capture of disease states in underserved populations. The injection of a blood draw directly into a portable device that requires no further operator interventions is a Critical Challenge. With today’s automated chemistry and a miniaturized flow cytometer this challenge could be met.

Voting

-6 net votes
4 up votes
10 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@marban)

Translational research need not be mechanistic

Translation means laying the groundwork to advance an idea into the clinic. Late-stage translation means doing what FDA and IRBs require to obtain approval for an IND or an IDE and the associated protocol to test a new idea in humans. Mechanism is the mantra for investigator-initiated research in NIH study sections, but translation is often painstaking detailed work that follows mechanistic investigations, which typically ...more »

Voting

-14 net votes
9 up votes
23 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@rsackstein)

How can we make cell therapy most effective?

In order to achieve the enormous promise of cell-based therapies (including stem cell-based therapies and adoptive cellular immunotherapies), we need to get the relevant cells to the sites where they are needed. Cell migration is critically dependent on expression of cell surface glycans that mediate adhesion between circulating cells and target tissue endothelial cells. We need to optimize these adhesive interactions ...more »

Voting

23 net votes
30 up votes
7 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@soldatovn.humgenex)

New funding mechanism for major diseases

According to the National Bioeconomy Blueprint" published in 2012 by the White House Office of Science and Technology Policy, “Flexibility in the use of new and existing funding mechanisms in and across agencies will be vital to stimulating the discovery of new bioinventions with potential to grow the bioeconomy” (p. 24). It is known that the most effective research program in American history was the Manhattan Project. ...more »

Voting

14 net votes
26 up votes
12 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@collerb)

Validating surrogate/intermediate clinical outcome endpoints for ST segment elevated myocardial infarction (STEMI)

The introduction of troponin assays has changed the criteria for myocardial infarction (MI), with much smaller myocardial damage now classified as an MI. Since to date, the FDA has not approved new agents based on their decreasing size of an MI, regulatory approval has required endpoints like death or heart failure that require large numbers of patients and long periods of time. Thus, it is difficult to attract industry ...more »

Voting

1 net vote
2 up votes
1 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Integrated healthcare strategies during transitions in COPD care

Integrated healthcare strategies during transitions in COPD care

 

• What is cost effectiveness of multi-component COPD programs?

 

• Will early admission to a Pulmonary Rehabilitation program following a hospitalization for COPD reduce the likelihood of readmission within the following year?

 

• What is the most effective time to implement the transition from hospitalization following a COPD exacerbation admission?

Voting

3 net votes
3 up votes
0 down votes
Active