Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.
(@sophpacz)

Goal 3: Advance Translational Research

Maximizing anti-tumor immunity following allogeneic HCT with biomarkers

Allogeneic hematopoietic cell transplantation (allo-HCT) is one of the most effective forms of tumor immunotherapy available to date. Allo-HCT can be life-saving for patients with aggressive malignancies that cannot be cured through other strategies. The immunotherapeutic efficacy of allo-HCT depends on donor T cell recognition of alloantigens on leukemic cells, which is known as the graft-versus-tumor effect (GVT). No ...more »

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32 net votes
52 up votes
20 down votes
Active
(@jnoel0)

Goal 3: Advance Translational Research

NEW INFRASTRUCTURE FOR CLINICAL RESEARCH IN SLEEP AND CIRCADIAN DISORDERS

Much of the current clinical research on sleep and circadian research depends on cohorts designed for other purposes. While this has been helpful, such studies have limitations. These limitations are related to availability of in-depth phenotyping data and questions as to whether individuals identified in population studies are equivalent to those who present clinically with specific disorders. These concerns could ...more »

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126 net votes
186 up votes
60 down votes
Active
(@nhlbiforumadministrator1)

Goal 3: Advance Translational Research

Healthcare Inequity

Many continue to pay higher benefits for less care. Often they are seniors who do not need OB/Gyn or pediatric benefits, etc. They are not covered for eyeglasses, dental work, etc. Those covered under Obama care plans and subsidies are entitled to more care. Now states are legalizing recreational drug use, same sex marriage, etc. Why? It is only logical to realize this will place more unnecessary burden on the already ...more »

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-10 net votes
5 up votes
15 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

A Pipeline for Investigator- Initiated Translational Science

How might the NHLBI effectively encourage and support its investigators to collaborate with strategic partners to pursue the early translation of their HLBS discoveries into new diagnostics and therapeutics? The critical challenges to effective early translation of discovery science experienced by the investigator community include: 1. The need for translational skills development, training and guidance 2. Need for ...more »

Voting

196 net votes
226 up votes
30 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Application of data science to extract information from EHR/EMR

There is a need to utilize bioinformatics to analyze electronic health records / electronic medical records (EHR/EMR) documentation of practice-based pulmonary and sleep medicine to better understand longitudinal care delivery patterns and outcomes, identify changes in evidence, inform practice, and foster reverse translation to integrate basic and clinical research.

Voting

54 net votes
81 up votes
27 down votes
Active
(@hgussin)

Goal 3: Advance Translational Research

Use of symptoms vs spirometry in increasing patient and provider adherence to guidelines

What is the comparative effectiveness of using symptoms vs. spirometry in increasing patient and provider adherence to COPD treatment guidelines and patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations)?

Voting

9 net votes
12 up votes
3 down votes
Active
(@zbigniew.m.szczepiorkowski)

Goal 3: Advance Translational Research

TREATMENT OF SEPSIS-MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS) UTILIZING APHERESIS BASED STRATEGIES

Sepsis, a systemic inflammatory response to infection, is the most common cause of death in non-cardiac intensive care units. The incidence and severity of sepsis have increased over the last two decades. With advances in supportive care, sepsis carries a mortality that averages 17%, however, this figure increases to 50 - 80% in Multiple Organ Dysfunction Syndrome (MODS), defined as failure of 3 or more organ systems. ...more »

Voting

97 net votes
115 up votes
18 down votes
Active
(@info00)

Goal 3: Advance Translational Research

Can hair follicle stem cells be transformed into new cells or organs?

Dr. Cotsarelis of the Univ. of Pennsylvania identified the bulge area of the hair follicle, which is now thought to contain the hair's stem cells. These cells would seem to be readily available and unique to an individual person. Can further work be done to transform these cells into now only hair cells but other organ tissues?

Voting

-15 net votes
5 up votes
20 down votes
Active
(@teresabarnes)

Goal 3: Advance Translational Research

Sustainability and Continuation of Research

While many challenges to advancing research efforts exist, a particularly confounding one for patient advocates is when promising research efforts are funded by NHLBI and the research is completed and published (leading to more questions) and is seemingly forgotten. This lack of continuity leads to further questions and is absent a solid path forward applying what has been learned to next steps in the research effort. ...more »

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87 net votes
106 up votes
19 down votes
Active
(@nhlbiforumadministrator)

Goal 3: Advance Translational Research

Direct thrombin inhibitors and anti-Xa (Ten A) inhibitors in trauma patients - physiologic effects and impact on outcomes

Direct thrombin inhibitors and anti-Xa (Ten A) inhibitors are new, undetectable and irreversible. We have no data on how well these drugs correlate with current measures of coagulopathy such as thromboelastography, or whether antifibrinolytics should be used in patients who are on these drugs. These drugs may increase incidence of traumatic brain injury after minor injury. They are also going to be used increasingly in ...more »

Voting

-7 net votes
6 up votes
13 down votes
Active