Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.

Goal 3: Advance Translational Research

Achieving Transplantation Tolerance in Recipients of Heart and Lung Allografts

Despite improvements in the early post-transplant survival of thoracic organs, registry data show that the graft half-life is only 11 years for heart recipients and 5 years for lung recipients. Infection accounts for 33% of cardiac and 40% of lung transplant recipient death between day 31 and one year post transplant. After 5 years, cardiac allograft vasculopathy (30%), and malignancy (23%) cause most cardiac recipient ...more »

Submitted by (@nhlbiforumadministrator)

Voting

7 net votes
24 up votes
17 down votes
Active

Goal 3: Advance Translational Research

Developing adherence research to reduce unnecessary mobility/mortality/cost

From Cochrane Review NOV 20 2014 RB Haynes “It is uncertain how medicine adherence can consistently be improved so that the full health benefits of medicines can be realized. We need more advanced methods for researching ways to improve medicine adherence, including better interventions, better ways of measuring adherence, and studies that include sufficient patients to draw conclusions on clinically important effects.” ...more »

Submitted by (@nhlbiforumadministrator)

Voting

5 net votes
7 up votes
2 down votes
Active

Goal 3: Advance Translational Research

Clinical Tools for Pediatric CVD Risk Reduction and Asthma Treat

What are effective strategies and clinical decision support tools that can maximize pediatric care providers’ adoption of evidence-based recommendations for assessment and treatment of cardiovascular risk factors and/or asthma? • Clinical recommendations and associated implementation tools are often incorporated into electronic medical records (EMRs). Currently there is no standard EMR format and therefore it is difficult ...more »

Submitted by (@nhlbiforumadministrator)

Voting

0 net votes
10 up votes
10 down votes
Active

Goal 3: Advance Translational Research

What are the most effective strategies for reducing alarm fatigue and optimizing cardiorespiratory monitor alarm management?

Hospital cardiorespiratory monitors have great potential to save lives, but are hampered by high false alarm rates that contribute to alarm fatigue. While the long term solution is developing new medical devices that will do this better, few hospitals will benefit from new device innovations in the next decade. In order to better identify early signs of cardiorespiratory deterioration in the hospital at an early stage ...more »

Submitted by (@chrisbonafide)

Voting

-6 net votes
4 up votes
10 down votes
Active

Goal 3: Advance Translational Research

It’s not just about adults…

Given the lack of outcomes data in the pediatric population, there is a need to develop a repository of data, including integrated electronic clinical data (outpatient, inpatient, laboratory, imaging, prescription), on all CVD risk factors (e.g. hypertension, dyslipidemia) in children. One approach is to start with leveraging health care systems that have existent electronic clinical data, infrastructure in place for ...more »

Submitted by (@nhlbiforumadministrator)

Voting

21 net votes
32 up votes
11 down votes
Active

Goal 3: Advance Translational Research

Palliative and hospice care for COPD patients

Does palliative care and/or hospice care as practiced across communities improve end-of-life care for COPD – specifically, does it reduce the burden of symptoms, improve HRQoL and satisfaction, reduce utilization in last 6 months of life (i.e. hospital visits, cost, invasive ventilation use, etc), improve the end-of-life experience, and increase the concordance of place of death to expressed patient preferences?

Submitted by (@k.willard)

Voting

12 net votes
16 up votes
4 down votes
Active

Goal 3: Advance Translational Research

Lipid and lipoprotein metabolism in the CNS

The analysis of lipoprotein metabolism has traditionally been restricted to the easily accessible circulation and peripheral tissues. Very little work has been done behind the blood brain barrier, where many of the lipid carrying or metabolizing genes are also expressed. Yet we know very little about their functions there, although for instance ApoE4 is THE primary risk factor for late-onset Alzheimer's disease. Conventional ...more »

Submitted by (@joachim.herz)

Voting

-4 net votes
7 up votes
11 down votes
Active