Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.

Goal 3: Advance Translational Research

Translational Cardiovascular Medicine

There is a need for the NHLBI to catalyze the development of tools and shared data resources to facilitate mechanistic studies in a human model system. This includes the ability to culture human cardiac tissue, as well as generate a resource to systematically characterize and catalog the epigenome and histone marks associated with the transcriptome in normal and diseased heart tissues.

Submitted by (@stacey.rentschler)

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Goal 3: Advance Translational Research

Research Priorities

There appears to be a move towards prioritizing funding opportunities towards the RO1 funding mechanism. A quote from someone else might describe this as "more funding for saving mice". To continue to make an impact on human health, it will be crucial to maintain mechanisms and sufficient levels of funding to answer questions directly relevant to saving lives and improving health of people which are not possible to accomplish ...more »

Submitted by (@susannemay)

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Goal 3: Advance Translational Research

How can we determine a patient’s risk of a life-threatening aortic dissection?

Even though science and technology has advanced, many of the advancements have not met the critical challenge of making significant changes in patient therapies for improved outcomes and thus have not been able to break through the translational barrier. In today’s world, risk of aortic dissection is still based purely on a crude size measurement. It is true that evidence indicates that aortic root aneurysm above 4.5 ...more »

Submitted by (@jgrima)

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Goal 3: Advance Translational Research

Achieving Transplantation Tolerance in Recipients of Heart and Lung Allografts

Despite improvements in the early post-transplant survival of thoracic organs, registry data show that the graft half-life is only 11 years for heart recipients and 5 years for lung recipients. Infection accounts for 33% of cardiac and 40% of lung transplant recipient death between day 31 and one year post transplant. After 5 years, cardiac allograft vasculopathy (30%), and malignancy (23%) cause most cardiac recipient ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 3: Advance Translational Research

Application of data science to extract information from EHR/EMR

There is a need to utilize bioinformatics to analyze electronic health records / electronic medical records (EHR/EMR) documentation of practice-based pulmonary and sleep medicine to better understand longitudinal care delivery patterns and outcomes, identify changes in evidence, inform practice, and foster reverse translation to integrate basic and clinical research.

Submitted by (@nhlbiforumadministrator)

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Goal 3: Advance Translational Research

TREATMENT OF SEPSIS-MULTIPLE ORGAN DYSFUNCTION SYNDROME (MODS) UTILIZING APHERESIS BASED STRATEGIES

Sepsis, a systemic inflammatory response to infection, is the most common cause of death in non-cardiac intensive care units. The incidence and severity of sepsis have increased over the last two decades. With advances in supportive care, sepsis carries a mortality that averages 17%, however, this figure increases to 50 - 80% in Multiple Organ Dysfunction Syndrome (MODS), defined as failure of 3 or more organ systems. ...more »

Submitted by (@zbigniew.m.szczepiorkowski)

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Goal 3: Advance Translational Research

Healthcare Inequity

Many continue to pay higher benefits for less care. Often they are seniors who do not need OB/Gyn or pediatric benefits, etc. They are not covered for eyeglasses, dental work, etc. Those covered under Obama care plans and subsidies are entitled to more care. Now states are legalizing recreational drug use, same sex marriage, etc. Why? It is only logical to realize this will place more unnecessary burden on the already ...more »

Submitted by (@nhlbiforumadministrator1)

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