Goal 4: Develop Workforce and Resources

To support the future of investigator-initiated research by sustaining and developing a diverse biomedical workforce with the skills and research resources to pursue emerging opportunities in science.

Goal 4: Develop Workforce and Resources

Creating research infrastructure through supporting the development of biorepositories and registries for rare lung diseases

Progress in rare lung diseases, such as interstitial lung diseases, has been hampered by a lack of patient-derived samples in large enough quantities or high-enough quality for systematic study. This is due to the inability of individual centers to recruit enough patients, and because of the varied samples each center obtains. Collecting, preparing, and storing such samples is not fundable by the NHLBI because it is not ...more »

Submitted by (@docew0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

The impact of addressing this Critical Challenge cannot be underestimated. Researchers throughout the country and the world are hamstrung by not being able to test hypotheses on reliable patient-derived samples. By supporting the creation of a biorepository of well-annotated, clinically-phenotyped biological samples from patients with interstitial lung disease, the scientific community will be able to attack many hypotheses simultaneously rather than individually as is currently the case. Utilizing an 'honest broker'-type system, researchers whose ideas have scientific merit will be able to access this trove of samples and data to confirm (or refute) their hypotheses. This type of resource does not exist but is critically needed.

Feasibility and challenges of addressing this CQ or CC :

Currently, few institutions care for a large proportion of interstitial lung disease patients nationwide. These institutions have already shown an ability to work together in other NHLBI-sponsored projects, such as IPFnet and LTRC. Thus, this project is feasible. Challenges that will need to be overcome include determining the appropriate samples to be collected, the centers that will participate in collecting samples and data, and identifying individuals or programs that can serve as an 'honest-broker' for this type of platform. However, engaging research partners among various centers has already been documented, with industry, academia, and patient advocacy groups coming together to support such an initiative.

Name of idea submitter and other team members who worked on this idea : Eric White

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-1 net votes
11 up votes
12 down votes
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Goal 4: Develop Workforce and Resources

Training approaches in lymphatic biology

The lymphatic vascular network connects the parenchymal interstitium through the nodes to the veins. Lymph serves as the transport pathway between these compartments and via its flow, controls interstitial fluid, macromolecular exchange, lipid absorption, immune cell trafficking and is critical to edema prevention/resolution, lipid metabolism, inflammation and immunity. Knowledge of this vascular network lags far behind ...more »

Submitted by (@dcz000)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

NIH has acknowledged that the lack of training in the field of lymphatic biology has impaired research progress in the area. Traditional methods that the NIH uses (T32) have not adequately addressed this issue as there are currently NO such programs in existence. One of the critical problems that must be overcome to advance the field is that few individual institutions in the US have a large enough body of lymphatic biology investigators to fit the classic training grant schemes. Overcoming this hurdle will significantly help advance research in the field. Consideration of other innovative approaches that utilize web-based or other methods to deliver distance education among local or regional institutions in this field should be investigated. Establishment of these innovative approaches would broaden the pool of investigators for research training and would significantly advance the field and thus be of high impact.

Feasibility and challenges of addressing this CQ or CC :

Research in the lymphatic biology field has historically lagged behind other vascular areas. However, interest in lymphatic biology and medicine has grown rapidly over the last decade. The Lymphatic Education & Research Network (formerly LRF) has had a long-standing commitment to developing research and training in lymphatic biology through its post-doctoral fellowship program, support for conferences/symposia and by providing travel funds for early-stage investigators to attend these meetings. Since very few places in the US have enough researchers trained and active in lymphatic biology, initiatives to broaden the base for research training would have to utilize novel approaches. Thus, the challenge will be to develop training programs that can address the needs of new lymphatic biologists at multiple institutions at geographically distributed sites. Approaches that use modern communication IT technology, and distance learning methods could deliver parts of the training. But innovative approaches to incorporate training beyond didactic learning need to be developed.

Name of idea submitter and other team members who worked on this idea : D. Zawieja

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12 net votes
13 up votes
1 down votes
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Goal 4: Develop Workforce and Resources

Research training to support population-focused obesity research in ethnic minority populations

NIH is already facing a challenge in increasing the number and viability of researchers of color. Obesity research in black (or other high risk minority) populations can be used to explore how research training programs that focus on specific issues of importance to populations of color might contribute to the recruitment and success of ethnic minority researchers in the NIH system.

Submitted by (@skumanyi)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

To say the least, not all researchers of color study disparities related issues and not all disparities research is done by researchers of color. That is the way it should be. However, I suspect that research focusing on populations of color would attract a greater than average proportion of researchers of color (NIMHD might have data on this but NIMHD funding alone would be grossly insufficient as the only relevant funding stream. It would also be inappropriate and ineffective to silo the entire burden as an NIMHD responsibility).

Feasibility and challenges of addressing this CQ or CC :

The infrastructure for such training might not exist. Isolated minority researchers attached to various centers and programs would not necessarily work; some sort of networking would have to be done based on an infrastructure devoted to population-oriented obesity research and with a critical mass of obesity researchers focusing on the black (or other) population..

Name of idea submitter and other team members who worked on this idea : Shiriki Kumanyika, Melicia Whitt-Glover, Debra Haire-Joshu

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6 net votes
6 up votes
0 down votes
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Goal 4: Develop Workforce and Resources

Increased methods training for investigators

It is clear that there are concerns about reproducibility and quality control in science in general and in obesity-related research in particular. Increased opportunities for training in rigorous scientific practices for obesity researchers and biomedical and behavioral researchers in general may be helpful to increase rigor and reproducibility.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : David B. Allison, Ph.D.; Kevin Fontaine, Ph.D.; Kathryn A. Kaiser, Ph.D.; Andrew W. Brown, Ph.D.; Edward C. Archer, Ph.D.

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2 net votes
2 up votes
0 down votes
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Goal 4: Develop Workforce and Resources

Encouraging Junior Scientists to be Mentors in T-32 Programs

To ensure continuity of mentorship across generations, should we create incentives to encourage participation of younger, junior faculty in the leadership of our T32 programs?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

To ensure continuity of mentorship across generations, teach junior investigators an important skill, alleviate the mentoring workload of more senior investigators.

Feasibility and challenges of addressing this CQ or CC :

Various types of incentive can be offered to junior investigators, some of them would need to be negotiated with the institutions.

Mentoring is an important part of a scientist life and is a skill that is learned by observation and practice. Good mentoring is essential for a successful career of any investigator. Encouraging young investigators to start mentoring from the early phases of their career will improve their skills and create a cadre of very competent future mentors.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

22 net votes
37 up votes
15 down votes
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Goal 4: Develop Workforce and Resources

RO1 funding rate

I would like to suggest the following changes in RO1 funding: (1) Reduce the amount but maintain the duration of each RO1 award to make academic research labs SMALLER but BETTER - This will force PIs pay closer attention to experimental design, to improve the efficiency and accuracy. It may entice more PIs to do more experiments themselves, the best way to reduce errors, maintain consistency and keep in touch with the ...more »

Submitted by (@gtseng)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Feasibility and challenges of addressing this CQ or CC :

This is simple math: when the amount of money is reduced but the number of RO1 applications is not, we will see a drop in the RO1 funding rate. This is frustrating, especially when we question the validity of data from some high-profile labs that list 4 or even more RO1 awards in the 'Acknowledgments' of their papers in high-impact journals. By reducing the amount of RO1 award, NIH can fund more (smaller) labs. This may break the monopoly (or at least reduce the impact) of some big labs in key research areas. The increased participation of small labs highly motivated to answer MORE questions with LESS costs will help revitalize the US Biomedical Research Enterprise.

Voting

-8 net votes
23 up votes
31 down votes
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Goal 4: Develop Workforce and Resources

Moderating Positive Feedback between Research Funding and PhD/postdoc Numbers

A critical challenge will be to limit future destabilizing expansion of the number of PhD students and postdoc trainees. Because 75-80% of biomedical PhD students and postdocs now supported by NIH are funded by RO1 and other research funding, if/when research grant budget increase the number of PhD and postdoc “slots” would automatically expand--even if there is no expectation of comparable increases in demand for ...more »

Submitted by (@teitelbaum)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Many including National Academies committees suggest that the 75-80% figure should be gradually reduced to around 50%, without increasing overall numbers, i.e. both limiting numbers supported under research grants and increasing numbers supported under training programs. Moderating the currently strong linkages of PhD/postdoc numbers to research funding should make future biomedical research careers more attractive than they have been in recent years.

Name of idea submitter and other team members who worked on this idea : Michael S. Teitelbaum

Voting

5 net votes
15 up votes
10 down votes
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Goal 4: Develop Workforce and Resources

Funding & Review Mechanisms

Funding and review mechanisms are essential resources that can facilitate or hinder innovative research to meet the NHLBI goals. These resources must be refocused to result in identification and funding of the type of innovative research being sought by NHLBI. The opportunities for leveraging available NHLBI funds with other sources should be considered formally as a component of overall budget planning, not just on ...more »

Submitted by (@media0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

The impact should be more equitable access to funds, as perceived by potential recipients; provision of funds for high-priority topics; and revitalized, refocused review groups that are willing and able to consider recommending high risk, innovative approaches.

Feasibility and challenges of addressing this CQ or CC :

This is a very specific challenge that may require incremental implementation with some experimentation/pretesting and solicitation of ideas from a range of stakeholders identified during this goal-setting exercise. While the Institute may be able to make changes in how funding mechanisms are employed, making changes to review group membership may be more challenging, especially in the current context of recruiting members. Incentives for this service may also need to be reviewed, innovatively, under current budget constraints.

Name of idea submitter and other team members who worked on this idea : Sonja McKinlay. Team Members: Susan Assmann and Paul Stark

Voting

4 net votes
8 up votes
4 down votes
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Goal 4: Develop Workforce and Resources

Preparing for Transdisciplinary Research

There is a need to develop training programs, mentorship, and collaborations that cross boundaries and prepare researchers for future transdisciplinary needs.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

10 net votes
18 up votes
8 down votes
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Goal 4: Develop Workforce and Resources

Bridge “translational gap”

Provide resources and training to improve the ability of scientists to bridge the “translational gap”. Continue and expand the VITA program.

Submitted by (@societyforvascularsurgery)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Society for Vascular Surgery

Voting

5 net votes
7 up votes
2 down votes
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Goal 4: Develop Workforce and Resources

Exposing students of all ages to Discovery science

What kinds of incentives, reforms, and exposures would work best with students from diverse and disadvantaged backgrounds to pursue careers in science?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

• It would produce an excited scientific workforce that will enhance healthcare and sustain discovery in the fields served by NHLBI.

Feasibility and challenges of addressing this CQ or CC :

• It is entirely feasible to develop programs for teachers and incentives for students.

• Pilot programs may be needed to establish feasibility of clinical training for PhDs and research training for MDs.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

7 net votes
20 up votes
13 down votes
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Goal 4: Develop Workforce and Resources

Development of IT tools to rapidly access key portions of the EHR

As the volume of information in EHR has continued to increase, one of the current challenges is how to find key pieces of information within the EHR. For example if a patient presents to the ED with Chest Pain as chief complaint, key information for that patient related to this chief complaint should be retrieved by the IT system and presented to the clinician for review such as prior ECG's, prior work-ups including any ...more »

Submitted by (@dayam0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Speed clinical care and reduce costs

Feasibility and challenges of addressing this CQ or CC :

Should be feasible but would require some partnering with HIS and AI companies to move this forward.

Name of idea submitter and other team members who worked on this idea : Mohamud Daya

Voting

2 net votes
4 up votes
2 down votes
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