Goal 4: Develop Workforce and Resources

To support the future of investigator-initiated research by sustaining and developing a diverse biomedical workforce with the skills and research resources to pursue emerging opportunities in science.

Goal 4: Develop Workforce and Resources

Promoting Research Careers

Given the declining numbers of physician scientists, NHLBI should expand the portfolio of opportunities for junior faculty who may want to consider a career in research.

Submitted by (@golan0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

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4 net votes
4 up votes
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Goal 4: Develop Workforce and Resources

Preserving and promoting expertise in integrative physiology

From my perspective, one of the key “critical challenges” facing the NHLBI in particular, and medical science in general, is to avoid being blinded by the promises of the reductionists in the “personalized, precision medicine” of the future. In order to understand the advances being made at the molecular level, we need to preserve and promote expertise in truly integrative physiology, what I like to call “PHYSIOMICS”. ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Unfortunately, human physiologists are being squeezed out of the medical industrial complex by the basic scientists on one end, and the epidemiologists on the other. Most departments of medicine now require on 80/20 commitment to have a significant research component of an academic career, and it is becoming increasingly difficult for those few of us physiologists remaining to compete with the pressures of both research funding and clinical mandates. I urge the leadership at NHLBI to preserve a strong focus on human physiology, and continue to support the small, but high resolution studies that are required to answer key research questions. I would submit that studying an individual patient’s unique physiology is as much “personalized” or “precision” medicine as it is to read their genome. Remember, despite billions of dollars of research support, there remains nothing better to predict the risk of diabetes, than a simple measure of waist size!

Name of idea submitter and other team members who worked on this idea : Benjamin Levine

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6 net votes
16 up votes
10 down votes
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Goal 4: Develop Workforce and Resources

Need to train and nurture more "translators"!

One of the major challenges in translating from bench-to-bedside and back is communication: the ability of basic and clinical scientists to understand each other's scientific language to be able to appreciate the importance of the other’s research questions and findings.

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Having an increased number of researchers able to connect dots across the continuum of translational research should increase overall success of translation of ideas into health.

Feasibility and challenges of addressing this CQ or CC :

This requires "rearranging" of already existing elements. Within 5-10 years of running specifically designed re/cross -training programs, the effects might be widely visible.

Basic scientists usually do not keep up with the latest outcomes of important clinical studies, and thus might miss important starting points for new basic research (e.g., negative trials that suggest the need for new hypotheses). The great majority of clinical scientists do not attend basic scientific sessions because are turned off by the specialized (dense/obscure) scientific terms used. Those who are interested in being translators have a hard time integrating and surviving in the "opposite camp" (i.e., at many medical schools, basic scientists are expected to bring in all their salary in a clinical department, and clinicians get little protected time for basic research)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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22 net votes
39 up votes
17 down votes
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Goal 4: Develop Workforce and Resources

Training in Small Molecule Discovery and Development

The current generation of heart,lung, and blood investigators are not equipped with competitive training needed to approach, design, and test appropriately small molecule therapeutics that may move through the FDA pipeline. Appropriate in silico ligan or structure based design, HTS, design of Pd/Pk models, "go-no-go" branchpoints in drug development, screening approaches, and drug target validation are issues that are ...more »

Submitted by (@mallampallirk)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

The incorporation of workshops, traditional funding mechanisms (T32, F32 etc) earmarked for this type of training will help position and equip NHLBI investigators to more effectively navigate through the landscape of drug discovery and development.

Name of idea submitter and other team members who worked on this idea : Rama Mallampalli, MD

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3 net votes
10 up votes
7 down votes
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Goal 4: Develop Workforce and Resources

Retaining Young Investigators

To ensure that young investigators remain in the field, the National Institutes of Health should consider strategies for assisting these investigators in making the career and funding move from mentored career development awards and career development awards for independent investigators (K awards) to research awards (including but not limited to R01 awards).

Submitted by (@skrenrich)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Cystic Fibrosis Foundation

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14 net votes
15 up votes
1 down votes
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Goal 4: Develop Workforce and Resources

Community education on phenotypic expressions of sickle cell disease

How effective are current community education techniques on the various phenotypic expressions of SCD?

Submitted by (@sicklecellwarrior)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

If parents knew what to expect with precision they could be proactive in care

Name of idea submitter and other team members who worked on this idea : Sickle Cell Warriors, Inc. community members

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17 net votes
27 up votes
10 down votes
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Goal 4: Develop Workforce and Resources

Development of IT tools to rapidly access key portions of the EHR

As the volume of information in EHR has continued to increase, one of the current challenges is how to find key pieces of information within the EHR. For example if a patient presents to the ED with Chest Pain as chief complaint, key information for that patient related to this chief complaint should be retrieved by the IT system and presented to the clinician for review such as prior ECG's, prior work-ups including any ...more »

Submitted by (@dayam0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Speed clinical care and reduce costs

Feasibility and challenges of addressing this CQ or CC :

Should be feasible but would require some partnering with HIS and AI companies to move this forward.

Name of idea submitter and other team members who worked on this idea : Mohamud Daya

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2 net votes
4 up votes
2 down votes
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Goal 4: Develop Workforce and Resources

Leveraging big data for T1 translational research

How best to train T1 investigators in using big health care data to test their basic science hypotheses related to heart, lung, blood, and sleep disorders and thus generate sufficient confirmation to justify clinical interventions.

Submitted by (@collerb)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

• Hypotheses that emerge from small studies of patients focused on mechanistic questions often are not able to be tested at the population level and thus remain unconfirmed. The increasing availability of big data from EHRs permits corroboration at the population level, but requires skills in framing queries and minimizing bias and confounders.

• The emergence of large clinical data sets such as PCORNet and the NIH Collaboratory make this particularly timely.

• By sampling existing data sets rather than having to conduct new randomized studies, this type of research can be performed at relatively low cost and in a much more timely way.

 

T1 investigators are not usually trained in the techniques of using large clinical data sets and so require targeted training.

Feasibility and challenges of addressing this CQ or CC :

Developing educational programs for T1 investigators should be straightforward. Resources will be required to support the queries by T1 investigators required as part of the training, but this should be modest compared to other forms of research.

Name of idea submitter and other team members who worked on this idea : Barry Coller

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2 net votes
3 up votes
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Goal 4: Develop Workforce and Resources

A Diverse world in prevention and provision of care

Why don’t we have a program that is easy to follow in maintaining at an early age that extends all the way to Senior Citizenship? Culturally diverse staff can improve everyones chances of getting needed care that is multi-cultural.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

We need a strike team of diverse brainstormers to address social issues that may be responsible for deseases do to associations and life styles. The majority of healthcare concerns are diverse and need someone who can retrofit services to be more responsive to all groups.

Feasibility and challenges of addressing this CQ or CC :

Most federal and state funding go to organizations that are high profile but not necessarily in touch with some peoples realities. Grassroot organizations need to be funded like in the past whose door don’t close at 4 or 5 PM when there is greater vulnerability.

Name of idea submitter and other team members who worked on this idea : James E. Cummings Sr

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-19 net votes
2 up votes
21 down votes
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Goal 4: Develop Workforce and Resources

Modernizing Research Training

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:

 

Since the focus of research has changed over the past decade, training programs need to be encouraged to use newer models of research in their training and mentoring of potential research faculty.

Submitted by (@wheeze)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Mitchell Grayson on behalf of the American Academy of Allergy, Asthma, and Immunology

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10 net votes
23 up votes
13 down votes
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Goal 4: Develop Workforce and Resources

Better oversight and transparency for diversity in our research portfolio

There needs to be better oversight and transparency for diversity in our research portfolio to include a steady pipeline of young investigators and to facilitate the entry of pediatricians into the research work force. Specifically, workforce diversity should be considered in addition to scientific merit in determining funding priorities.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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1 net vote
1 up votes
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Goal 4: Develop Workforce and Resources

Promoting Translational Research training using the R03 mechanism

We in Wisconsin have developed a robust training program for mixed MD and PhD postdocs in a clinical dept and yet their future in research is blocked by few faculty positions, poor funding and over complicated NIH applications. One of the simplest grants is the R03 and we have already had graduates with only a few years postdoc experience succeed in gaining R03 funding. The R03 is a very simple very flexible mechanism. ...more »

Submitted by (@ianbird)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

More MD and PhD Postdoc trainees will spend more time focused on work and less writing grants - and the efficiency of expenditures by NIH would go up in terms of paper generated per dollar. MDs who may have a desire to dip in and out of funded research as their clinical path demands would be able to do that. R03 funding does not at any time change your status as a new or early career investigator. Its perfectly reasonable to hold more than one even without a faculty title but as a PhD scientist or practicing clinciian.

Feasibility and challenges of addressing this CQ or CC :

Its easy to do - just decide to do it. Also writing an R03 is the best possible training for writing an R01. I run a T32 for predocs and I mentor K12 postdocs. I know what NIH INTENDS in its training grants. But also recognize just to take on the longer and longer and more demanding K application after already being well trained is a real disincentive to everyone, even if those pages in training plan are well intentioned. IF omeone has not had the chance to train or is cross training to a new area then a K99 is perfect. But someone who is well trained, may stay in their area and has already proven themselves needs a fast submission fast review process to get funding NOW that may be the difference between continued employment though this funding crisis or not. This could provide that for them. Especially with expedited review!

Name of idea submitter and other team members who worked on this idea : Ian Bird

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10 up votes
11 down votes
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