Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Submitted by (@lesliesmyth)

Missing upper teeth & sleep apnea treatment: Problems?

I am a 73 year old female with Hypersensitivity Pneumonitis, Complex Sleep Neap, using oxygen @ 4-5 L/min 24/7 who just had my upper teeth extracted. I notice this has a negative effect, or appears to, on the effectiveness of apnea treatment. I wake several times during the night with lips flapping! This did not happen before the extraction. Because there are still some lower teeth, I am unable to close my mouth tightly ...more »

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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

Functional and high throughput screening assays

There is a need to develop functional assays and high throughput screening to develop probes and potential drug therapies. A. Functional Assays. Researchers face a challenging gap between identifying many sequence variations of potential interest and recognizing which of these variations have a direct functional effect on the physiological system of interest, as opposed to merely being associated with the actual causal ...more »

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Goal 1: Promote Human Health

Submitted by (@jmrommes)

What is the potential effect of the burden of COPD on the US workforce?

COPD currently affects approximately 25 million individuals in the US alone, many of whom are of working age, according to the most recent BFRSS data. Many of those people are encouraged by their doctors or families to apply for disability and receive it, even though there are still jobs they could do. This is going to have an impact on business and industry as these people who are at the peak of their careers leave. ...more »

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8 net votes
15 up votes
7 down votes
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Goal 1: Promote Human Health

Submitted by (@jbsoriano2)

what about smoking?

We must keep reminding ourselves that tobacco is the first and foremost causal, avoidable risk factor for human disease, and perhaps it has been neglected too often in the past in many medical venues. , Therefore, the NHLBI should welcome initiatives on key tobacco-related translational issues, and on the efficacy and the effectiveness of any smoking reduction and/or avoidance interventions, as well as on any other risk ...more »

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Goal 1: Promote Human Health

Submitted by (@gcioffi)

Continued focus on mechanism of Red Cell Production

Recent murine studies and early phase clinical trials demonstrate that pharmacologic “traps” for TGF-beta family members may stimulate erythropoiesis in non-erythropoietin-dependent mechanisms. The molecular details of this process remain to be elucidated. Better understanding of this process, which may markedly decrease the marrow problem of “ineffective erythropoiesis,” may lead to improved therapies in thalassemia, ...more »

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47 net votes
57 up votes
10 down votes
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Goal 1: Promote Human Health

Submitted by (@dayam0)

Non-opioid management of pain

The use of opioid agents has increased dramatically in the United States. Prescription drug overdoses now account for more deaths than traumatic injuries in the 1-44 age group. There is a need for more high level evidence to target optimal pain management strategies in the acute (ED) and non-acute settings (office practice) especially for chronic disorders such as low back pain, headaches, fibromyalgia, acupuncture etc. ...more »

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Goal 1: Promote Human Health

Submitted by (@glancast)

Updating level C evidence in Clinical Guidelines

Clinical Guidelines depends on good science. Despite this, only 11% of guidelines that reported level of evidence in 2009, had level of evidence A while 48% had level C. Studies have shown that recommendations based on Level of Evidence C (or their equivalence) are significantly less reliable and may be downgraded, reversed or omitted when better evidence is available. I propose a comprehensive review of ACC/AHA ...more »

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