Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Non-opioid management of pain

The use of opioid agents has increased dramatically in the United States. Prescription drug overdoses now account for more deaths than traumatic injuries in the 1-44 age group. There is a need for more high level evidence to target optimal pain management strategies in the acute (ED) and non-acute settings (office practice) especially for chronic disorders such as low back pain, headaches, fibromyalgia, acupuncture etc. ...more »

Submitted by (@dayam0)

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Goal 1: Promote Human Health

Developing tools and resources for studying sex differences

There is a need to promote sex balance in research. We know that existing and emerging scientific evidence supports the notion that sex is a major determinant for the development and progression of cardiovascular disease. Thus, expansion of resources for relevant animal models of disease, and the creation of databases that collect sex as a biological variable are important for both pre-clinical and clinical studies.

Submitted by (@nhlbiforumadministrator1)

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Goal 1: Promote Human Health

The CRISPER-Cas challenge: Need to re-phenotype KO animals?

Because traditional knock out models and CRISP/Cas models often show different phenotypes for the same gene deletion, do we need to re-phenotype hundreds/thousands of knock out animal models and revisit the conclusions of many studies based on using these animal models? This research may not appear very innovative but may be very important for drawing correct conclusions about gene functions and interactions - should ...more »

Submitted by (@nhlbiforumadministrator1)

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Goal 1: Promote Human Health

Transforming Transplantation with RISC

What is necessary to reprogram the immune system to improve transplant outcomes of hearts, lungs, and hematopoietic cells? While NIAID is a major funder of immunology research, we are a major contributor to stem cell research. Our resources could be combined, where NIAID would support this approach for autoimmune diseases, and we would support work in tolerance for transplants. If the NCI also wants to collaborate on ...more »

Submitted by (@nhlbiforumadministrator1)

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Goal 1: Promote Human Health

What administrative changes might facilitate team science? Update peer-review and budget mechanisms for team science.

NIH peer-review methods were developed at a time when biomedical science was generally conducted by individual investigators. Approaches to defining conflict of interest in peer review that worked well for individual investigators may not be fit for the review of large-scale collaborative projects. Similarly, the subcontract mechanisms are often slow and cumbersome at a time when projects need to be nimble and timely. ...more »

Submitted by (@psaty0)

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Goal 1: Promote Human Health

Psychological Stress and Cardiovascular Health

Our new Surgeon General Dr. Vivek Murthy said recently that one of this four rules for health was "...making sure I’m focusing on my emotional and mental well-being." A majority of Americans reporting moderate to high levels of stress (American Psychological Association, 2014), and evidence links psychosocial aspects of stress and cardiovascular health. Therefore, just as Dr. Murthy highlights well-being as a foundation ...more »

Submitted by (@tomiyama)

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Goal 1: Promote Human Health

How do Circulating Precursor Endothelial Cells contribute to newly formed vessels

Endothelial cells derive from cells in the bone marrow. Circulating precursor endothelial cells contribute to newly forming vessels.

Do Alk 1 and/or Endogln mutations affect the functions of these cells once they incorporate into growing vessels. These vessels then go on to form arteriovenous malformations

Submitted by (@mariannes.clancy)

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