Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator1)

The CRISPER-Cas challenge: Need to re-phenotype KO animals?

Because traditional knock out models and CRISP/Cas models often show different phenotypes for the same gene deletion, do we need to re-phenotype hundreds/thousands of knock out animal models and revisit the conclusions of many studies based on using these animal models? This research may not appear very innovative but may be very important for drawing correct conclusions about gene functions and interactions - should ...more »

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Goal 1: Promote Human Health

Submitted by (@dayam0)

Non-opioid management of pain

The use of opioid agents has increased dramatically in the United States. Prescription drug overdoses now account for more deaths than traumatic injuries in the 1-44 age group. There is a need for more high level evidence to target optimal pain management strategies in the acute (ED) and non-acute settings (office practice) especially for chronic disorders such as low back pain, headaches, fibromyalgia, acupuncture etc. ...more »

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Goal 1: Promote Human Health

Submitted by (@ryanr0)

Developmental Origins of Adult Lung, Heart and Blood Disease

It all starts in childhood. Yet it is difficult to find funding to really study these questions because the follow up timeline is long and thus very expensive but critically important. We don't even know what the "right" way to feed infants is in the first year of life to both limit cardiometabolic syndrome but also preserve neurodevelopmental outcome. We also have just started to see the tii of the iceberg in understanding ...more »

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Goal 1: Promote Human Health

Submitted by (@jhagood)

Crowdsource NIH Funding

Congress doesn't seem to "get it" regarding the return on investment for biomedical research, but maybe the public does. Create a mechanism whereby individuals can donate directly to the NIH to support research in specific areas (or provide general support).

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Goal 1: Promote Human Health

Submitted by (@rpate0)

Prevention of Obesity

What are the behavioral factors that predispose to excessive weight gain and development of obesity? And, which intervention strategies can effectively prevent excessive weight gain and obesity? NHLBI, other NIH institutes and the society at-large have invested heavily in research and clinical practice aimed at treatment of obesity (i.e, weight loss in those who are already overweight). However, much less research ...more »

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Goal 1: Promote Human Health

Submitted by (@gaynor)

Improving longterm outcomes after surgery for congenital heart disease

Survival has improved but neurobehavioral disabilty remains a common complication with adverse impacts on quality of life, educational and occupational attainments, and resource utilization. There is increasing evidence that brain development is abnormal, and leads to a rrisk of peri-operative brain injury. Studies are needed to; 1. Further define the prevalence and spectrum of neurobehavioral disability. 2, Understand ...more »

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