Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Injury, regeneration and repair of the developing lung

Understanding injury, regeneration and repair of the developing lung.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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Goal 1: Promote Human Health

Investigating Co-Morbidities in Women's Cardiovascular Health

There are important questions related to the cardiovascular health of women, and particularly to diagnostic and therapeutic challenges arising from the common existence of co-morbid conditions. The latter consideration, as well as the limitations of the budgets of individual institutes and centers at the NIH, suggest that it may be reasonable for the NHLBI to consider cross-NIH collaborations with I/Cs that have related ...more »

Submitted by (@rosemarie.robertson)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Collaboration across I/Cs could encourage investigators or teams to explore new concepts underlying the etiology of common or rare cardiovascular diseases (CVD), including stroke, particularly those with gender-related differences. In addition, clinical research on these disorders would benefit from active consideration of the common co-morbidities seen in patients with CVD, especially as patients with these co-morbidities are often specifically excluded from clinical trials. Since the patients who will ultimately benefit from treatments developed will often suffer from multiple other disorders, the societal benefit would be substantial. While any single I/C could support such studies, collaborative funding would be likely to bring together new teams of investigators with novel ideas.

Feasibility and challenges of addressing this CQ or CC :

We believe that there is likely to be a good response from investigators, both basic and clinical, to collaborative, multi-I/C RFAs. It might be of additional benefit to provide some funds specifically for teams that are newly collaborative in response to the RFAs, to encourage increased cross-field collaboration.

Name of idea submitter and other team members who worked on this idea : Rose Marie Robertson for American Heart Association

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3 net votes
3 up votes
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Goal 1: Promote Human Health

Microbiome and hypertension

What is the connection between the gut microbiome and the development of hypertension?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Help understand the normal and pathophysiology of human hypertension and related disorders, such as metabolic syndrome, diabetes, obesity, and stroke.

Feasibility and challenges of addressing this CQ or CC :

Yes., this is feasible.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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7 net votes
25 up votes
18 down votes
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Goal 1: Promote Human Health

Hand Held Device to treat PTSD and Traumatic Brain Injury

Undo Obesity, Now! Hand Held Electronic Device to Treat Obesity Undo PTSD/TBI Hand held vagus nerve stimulator for PTSD and traumatic brain injury PTSD may be similar to depression and epilepsy. Traumatic brain injury may relate to nerve injury and nerve inflammation Vagus nerve stimulation causes nerve function regeneration. Vagus nerve stimulation stops inflammation. Vagus nerve stimulation treats depression. Vagus ...more »

Submitted by (@chrislahr22)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

This could revolutionize the treatment of PTSD and traumatic brain injury. No drugs, no surgery.

Feasibility and challenges of addressing this CQ or CC :

App is in development.

Power source and electrical wave generator produced by Apple

Stimulator cord produced by Apple.

Ear Stimulator in production by General Motors Global Research and Development.

Name of idea submitter and other team members who worked on this idea : Chris Lahr, Nitin Gupta,Derek Lahr, Christian R. Gomez, Ingrid Espinoza, Ryan Marshall, Thomas Abell, Omer H. Yilmaz

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Goal 1: Promote Human Health

Few reviewers in R01 study sections are from minority institutes

Recruitment of investigators who had or currently have R01 and equivalent grant awards from minority institutes to R01 study sections will diminish this under-representative situation.

Submitted by (@hyang0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Hong Yang

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-2 net votes
11 up votes
13 down votes
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Goal 1: Promote Human Health

Nefarious substances in the US blood supply

Prescription and illicit drug is everpresent in the US, which can potentially result in controlled substances entering the US blood supply. Passive transfer of immune allergens is only anecdotally been reported as peanut allergens, fish allergens, and contrast material. However, US blood donors are only screened for a limited number of medications on the universal donor health questionnaire at time of collection. What, ...more »

Submitted by (@garrett.s.booth)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Of the nearly 15 million blood products collected in the US (National Blood Collection and Utilization Survey), what percent of donations capture additional substances like medications and illicit substances. Healthcare providers may be unaware of potential adverse transfusion reactions that could arise from potent allergens within the products themselves.

If additional donor screening is required to reduce the number of medications/drugs entering the US blood supply, how best to do this? Via blood toxicology, urine toxicology, hair toxicology? Is there a need to marry the donor drug history with the recipient allergy list?

Feasibility and challenges of addressing this CQ or CC :

These questions would require blood collection centers to potentially revise how they screen blood donors. How and when to probe donations or donors will require extensive medical-legal investigation.

Name of idea submitter and other team members who worked on this idea : LostInNashville

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-11 net votes
6 up votes
17 down votes
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Goal 1: Promote Human Health

Microbiome, immunity and health

What is the influence of the microbiome on the immune system and other development processes across the normal human lifespan?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

There is a potential of microbiome-based therapeutics to treat human disease. A deep understanding of the mechanisms governing the interactions between microbiomes, immune development and metabolic networks are key to improve health outcomes. New therapeutic approaches including personalized pre- and probiotics and nutritional interventions, narrow spectrum antibiotics and fecal transplantation therapies may provide an avenue for safer alternatives to traditional clinical interventions for chronic diseases.

Feasibility and challenges of addressing this CQ or CC :

Through the Human Microbiome Project investigators have started to characterize and analyze the microbial communities in the body. Today metagenomics tools and other technologies developed through these projects are available to the broader scientific community. Such tools and standardized protocols can be applied and improved in future research to address functional and mechanistic consequences of host-microbiome interactions and their influence in human health.

Bacterial communities colonize the human host from birth, giving rise to a highly adapted microbiota that is established, but dynamic, in healthy individuals though life. Growing evidence suggests that this complex symbiotic relationship between microbiome and its host fulfills critical physiological roles, immune maturation, and diverse metabolic functions. Immune maturity and balance is conquered and maintained partly due to the influential interaction among the resident gut microbiota and host mucosal immune system. In addition, the immune system is continuously stimulated by chronic systemic viruses; the human virome is considered one of the drivers of idiopathic systemic inflammation that has been linked to many of the most severe public health threats, including cardiovascular diseases. In depth understanding of the underlying mechanisms that control homeostasis and dysbiosis (microbial imbalance) of the gut, lung and/or other host microbiota are vital for our ability to potentially manipulate the microbiota to achieve positive clinical outcomes for systemic diseases.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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47 net votes
77 up votes
30 down votes
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Goal 1: Promote Human Health

leveraging EHR through improved partnerships

Large medical delivery systems have an abundance of information stored in their EHR systems. What steps are necessary to develop partnerships between NHLBI and medical delivery systems or other agencies such as AHRQ to access these EHR systems, develop a common terminology (if icd 9 and other common codes are ineffective for merging data) and add that data to dbGap for NIH/community use?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Accessing the EHR systems of the large care systems would provide a wealth of knowledge/data for the research community.

Feasibility and challenges of addressing this CQ or CC :

The stored data will only expand in the EHR systems and it would certainly be of value and interest to any number of research projects.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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1 net vote
13 up votes
12 down votes
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Goal 1: Promote Human Health

Lung Repair and Regeneration

What characteristics define progenitor lung cell niches? What controls proliferation and differentiation of lung progenitor cells in normal repair? Can endogenous repair mechanisms and alterations of progenitor cell cycle be harnessed to promote regeneration?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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10 net votes
22 up votes
12 down votes
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Goal 1: Promote Human Health

Developing predictive models

The need for sophisticated analytic methods to address multidimensional data to facilitate the development of predictive models.

Submitted by (@rebecca.lehotzky)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : AHA Staff & Volunteers

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1 net vote
4 up votes
3 down votes
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