Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Global cohorts to fill gaps in knowledge

Given the global burden of disease, what does NHLBI plan to do to establish a diverse global cohort to connect basic sciences to population health, in a way that differences in phenotypes around the world can be studied rapidly? For example, why not start by supporting a coalition of cohorts originally funded by the Global Heart Initiative?

Submitted by (@nhlbiforumadministrator)

Voting

-8 net votes
5 up votes
13 down votes
Active

Goal 1: Promote Human Health

Engineering Healthy Lungs

What tools and knowledge are required to engineer healthy lungs? Can we engineer lungs and/or successfully modify cadaveric donor lungs using our understanding of matrix biology and lung development to provide a durable effective organ replacement therapy for patients with advanced lung disease?

Submitted by (@nhlbiforumadministrator1)

Voting

2 net votes
8 up votes
6 down votes
Active

Goal 1: Promote Human Health

Do our modern "traditional" sleep schedules defy nature?

Here's an interesting article which shows that the modern tradition of eight hours of unbroken sleep might actually be unnatural, and quite different from what our ancestors typically did: http://www.bbc.com/news/magazine-16964783 So, maybe the majority of our modern societies (even the people without recognized sleep disorders) are unwisely fighting against biology? Perhaps a lot of people's health issues, such as ...more »

Submitted by (@apollia112)

Voting

5 net votes
23 up votes
18 down votes
Active

Goal 1: Promote Human Health

Investigating Co-Morbidities in Women's Cardiovascular Health

There are important questions related to the cardiovascular health of women, and particularly to diagnostic and therapeutic challenges arising from the common existence of co-morbid conditions. The latter consideration, as well as the limitations of the budgets of individual institutes and centers at the NIH, suggest that it may be reasonable for the NHLBI to consider cross-NIH collaborations with I/Cs that have related ...more »

Submitted by (@rosemarie.robertson)

Voting

3 net votes
3 up votes
0 down votes
Active

Goal 1: Promote Human Health

Brain-Heart Connections

Depression and CHD will become the 2 leading causes of disability in the next decade. Chronic as well as traumatic stress increases CVD risk by about 50%. Although we understand that there are connections between psychosocial stress, affective disorders, and CVD, we do not understand the vast array of brain areas that impact the CV system and the mechanisms connecting them. Neuroscience has made great leaps in understanding ...more »

Submitted by (@cshively)

Voting

9 net votes
14 up votes
5 down votes
Active