Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Global cohorts to fill gaps in knowledge

Given the global burden of disease, what does NHLBI plan to do to establish a diverse global cohort to connect basic sciences to population health, in a way that differences in phenotypes around the world can be studied rapidly? For example, why not start by supporting a coalition of cohorts originally funded by the Global Heart Initiative?

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-8 net votes
5 up votes
13 down votes
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(@dburand)

Goal 1: Promote Human Health

Using video to replace the boring highly ineffective drug monographs that accompany prescrptions

Estimates are that less than 2% of medication monographs are actually read by patients. Of those 2% only 35% fully comprehend the material. Why not use video and simpler methods to educate patients about their medicine. By coding QR tags to direct patients to education websites, we solve the drive through phenomena, the health literacy issue, and the language barrier.

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-12 net votes
4 up votes
16 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Transforming Transplantation with Reprogramming Immune System Cells (RISC)

Can we "reprogram" the immune system to improve outcomes of heart, lung, and hematopoietic cell transplants? While NIAID is a major funder of immunology research, we are a major contributor to stem cell research. Our resources could be combined, where NIAID would support this approach for autoimmune diseases, and we would support work in tolerance for transplants. If the NCI also wants to collaborate on co-stimulatory ...more »

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15 net votes
27 up votes
12 down votes
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(@wchilian)

Goal 1: Promote Human Health

Intersecting Developmental Biology with Vascular Physiology and Biology

Although many think of the vasculature as a lump sum of vessels that all react in a similar fashion to a certain stimulus, e.g., alpha-adrenergic activation, this is not the situation. For example, coronary resistance vessels show little to no direct response to alpha-adrenergic activation while resistance vessels in most organs show marked constriction. Another example is the response of different vessels to angioplasty ...more »

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15 net votes
26 up votes
11 down votes
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(@jnoel0)

Goal 1: Promote Human Health

ELUCIDATING BASIC MECHANISMS OF SLEEP DEFICIENCY AND CIRCADIAN DISRUPTION ON HEALTH THROUGH THE LIFESPAN

There are developing data from clinical studies that sleep deficiency and circadian disruption have multiple adverse consequences for health. The clinical data provide the base for mechanistic studies. Studies in animal models indicate that both circadian disruption and insufficient sleep later gene expression in peripheral tissues. Moreover, the effect of sleep loss in molecular changes in brain changes with age. ...more »

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174 net votes
230 up votes
56 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Lung Repair and Regeneration

What characteristics define progenitor lung cell niches? What controls proliferation and differentiation of lung progenitor cells in normal repair? Can endogenous repair mechanisms and alterations of progenitor cell cycle be harnessed to promote regeneration?

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10 net votes
22 up votes
12 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Bypass the CSR and concurrently act to help reform it

A key aspect of making any strategic plan focused upon glycoscience funding effective is the mechanisms by which grants are chosen. The problem is not the IC and making prioritized decisions; the problem is the study section ignorance and bias. Proposals that are reviewed poorly in study section out of flippancy towards glycobiology or simple lack of a critical mass of appropriate expertise never see the light of day ...more »

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1 net vote
1 up votes
0 down votes
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