Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Submitted by (@hvd000)

Understanding Individual Differences in Responses to Sleep Loss

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to ...more »

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124 net votes
171 up votes
47 down votes
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Goal 1: Promote Human Health

Submitted by (@jmrommes)

What is the potential effect of the burden of COPD on the US workforce?

COPD currently affects approximately 25 million individuals in the US alone, many of whom are of working age, according to the most recent BFRSS data. Many of those people are encouraged by their doctors or families to apply for disability and receive it, even though there are still jobs they could do. This is going to have an impact on business and industry as these people who are at the peak of their careers leave. ...more »

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8 net votes
15 up votes
7 down votes
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Goal 1: Promote Human Health

Submitted by (@dxiao0)

Nicotine abuse and fetal programming of heart ischemic disease

It is well-known that cigarette smoking is a major risk factor of heart ischemic disease. However, little information is known about the maternal smoking and fetal programming of heart ischemic disease in adulthood. Recently, e-cigarette (nicotine use) during pregnancy is a worldwide health concern. Epidemiologic studies have indicated that cigarette smoking during pregnancy is associated with an increased risk of cardiovascular ...more »

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-3 net votes
5 up votes
8 down votes
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Goal 1: Promote Human Health

Submitted by (@jnoel0)

ROLE OF HEALTH DISPARITIES IN SLEEP AND CIRCADIAN HEALTH—ENVIRONMENT

Self-report data indicate that insufficient sleep is more common in minority populations. This seems to be related to socioeconomic status. There is a need to move this beyond self-report and obtain objective measures in the relevant populations. Moreover, the basis of this difference needs to be established. What aspect of the environment leads to these differences, e.g., noise, stress related to sense of vulnerability, ...more »

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122 net votes
173 up votes
51 down votes
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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

The Human Virome and Host Interactions in Heart, Lung, and Blood

What are the unknown elements of the human virome, and what host-virome interactions affect the heart, lung, and blood health and diseases? A major challenge has been the need for in vitro culture systems and animal models for studying the virome, which is a significant limitation that has forced current studies of the virome to be mostly descriptive. NHLBI has supported one research group to identify human virome and ...more »

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13 net votes
29 up votes
16 down votes
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Goal 1: Promote Human Health

Submitted by (@yanyunw)

Study wellness instead of diseases by longitudinal follow-up of frequent and long term blood donors

Blood donors (especially young donors) in general represent healthy populations. Longitudinal follow-up of frequent and long term blood donors can be useful to establish data and sample sources for the study of wellness, instead of disease (especially for blood diseases). Not only it can be used as healthy controls, it can also be used to predict the wellness factors such as genetic variation, life style, exercise patterns, ...more »

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2 net votes
2 up votes
0 down votes
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Goal 1: Promote Human Health

Submitted by (@greg.martin)

Predictive analytics to engage healthy behaviors and maintain health while reducing cost

Predictive Health employs the principle that using modern health testing and predictive analytics will better define true health (not just absence of disease) and, in combination with large-scale data analytics, will facilitate predicting deviations from the healthy trajectory earlier than traditional disease diagnosis, thus allowing more effective and less costly interventions to maintain health. Predictive Health educates ...more »

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5 net votes
9 up votes
4 down votes
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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

A Systems Approach - Human Cardiac Electromechanical Activity

The challenge is to identify limitations in using data from non-human animal species for elucidation of human electromechanical function/activity and to identify what specific information and computational approaches need to be incorporated. To aid in achieving such a goal, it might be useful to convene a series of workshops to build consensus and improve communication among investigators working at the same horizontal ...more »

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7 net votes
20 up votes
13 down votes
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