Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

Transforming Transplantation with Reprogramming Immune System Cells (RISC)

Can we "reprogram" the immune system to improve outcomes of heart, lung, and hematopoietic cell transplants? While NIAID is a major funder of immunology research, we are a major contributor to stem cell research. Our resources could be combined, where NIAID would support this approach for autoimmune diseases, and we would support work in tolerance for transplants. If the NCI also wants to collaborate on co-stimulatory ...more »

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Goal 1: Promote Human Health

Submitted by (@yanyunw)

Study wellness instead of diseases by longitudinal follow-up of frequent and long term blood donors

Blood donors (especially young donors) in general represent healthy populations. Longitudinal follow-up of frequent and long term blood donors can be useful to establish data and sample sources for the study of wellness, instead of disease (especially for blood diseases). Not only it can be used as healthy controls, it can also be used to predict the wellness factors such as genetic variation, life style, exercise patterns, ...more »

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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator)

Extreme makeover: harnessing adaptation mechanisms for therapy

What extreme adaptive physiological mechanisms in heart, lung, and blood systems might have the greatest potential to be targeted or employed in therapeutic strategies? Human physiology, including the heart, lung and blood systems, is known to possess extreme adaptive mechanisms to counter extreme conditions or unusual situations. Although some studies are being done, many of these mechanisms have not been fully explored ...more »

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Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator1)

Smart Biomaterials for Self-Adjusting Implants

There is a need to leverage ongoing research on active materials (e.g., self-regenerating body armor, insulin-releasing polymers that respond to glucose, etc.) to stimulate the invention of new materials and constructs that are electrically, chemically and mechanically active to enable self-adjusting bioengineered implants.

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Goal 1: Promote Human Health

Submitted by (@neil.zakai)

Using the Electronic Health Record to improve population and individual health.

Every year millions of individuals suffer diseases of the heart, lungs, and blood. Some diseases have centralized care but rare diseases and diseases treated by a variety of provider types are difficult to study. The electronic health record feels primarily a tool for billing rather than for improving individual and population health. The challenges are:: 1. How can we structure a clinical health record which can ...more »

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12 net votes
22 up votes
10 down votes
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Goal 1: Promote Human Health

Submitted by (@jlaakso)

Examining the interface between physiological and pathophysiological angiogenesis and placental function in at risk pregnancies.

Abnormal placental function, characterized by retarded nutrient and oxygen exchange, and abnormal hormone and angiogenic growth factor production, is linked to a number of diseases that have a strong impact on maternal and fetal health. Perhaps of highest impact is pre-eclampsia, a disease affecting 5-8% of pregnant women worldwide. Moreover, issues related to a suboptimal intrauterine environment leading to growth ...more »

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