Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Examining the interface between physiological and pathophysiological angiogenesis and placental function in at risk pregnancies.

Abnormal placental function, characterized by retarded nutrient and oxygen exchange, and abnormal hormone and angiogenic growth factor production, is linked to a number of diseases that have a strong impact on maternal and fetal health. Perhaps of highest impact is pre-eclampsia, a disease affecting 5-8% of pregnant women worldwide. Moreover, issues related to a suboptimal intrauterine environment leading to growth ...more »

Submitted by (@jlaakso)

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Goal 1: Promote Human Health

Obesity and Morbid obesity

Obesity is a pervasive disease. It contributes to serious diseases such as heart, all the way down to cancer. In the past five decades it has been confirmed that the sugar from rich carbohydrate (CHO) foods increases the production of insulin which in turn converts the excess caloric intake into fat. So far neither dieting with highly processed foods rich in CHO’s, nor radical surgery have made a dent in this most ...more »

Submitted by (@baz200)

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Goal 1: Promote Human Health

ESTABLISH NORMATIVE AGE- AND GENDER-SPECIFIC DATA FOR SLEEP DISRUPTION, SLEEP QUALITY AND CIRCADIAN TIMING

There is growing evidence that sleep durations are progressively declining in the United States. Moreover, sleep durations are different at different ages and in different ethnic groups. Currently definitions of normal are based on consensus since there is a lack of key data. Defining normal as with FEV1 is a critical step.

Submitted by (@jnoel0)

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Goal 1: Promote Human Health

Combinatorial intervention of immune dynamics to combat cariovascular disease

Human health and disease are modulated by complex and inter-connected dynamic processes. With particular significance, a well-balanced immune environment may play a key role in maintaining health and preventing the pathogenesis of cardiovascular disease. Defining the dynamic programming and balance of immune environment will be the key for combinatorial therapies to reset homeostasis.

Submitted by (@lwli00)

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Goal 1: Promote Human Health

Identify genetic variants of sleep/circadian disorders

Most aspects of variation in sleep and circadian rhythm are heritable. Moreover, all common sleep disorders aggregate in families. The response to sleep loss is also a highly heritable trait. Identifying gene variants for these disorders will elaborate new molecular pathways that could be targets for future interventions.

Submitted by (@jnoel0)

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Goal 1: Promote Human Health

Understanding Individual Differences in Responses to Sleep Loss

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to ...more »

Submitted by (@hvd000)

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Goal 1: Promote Human Health

Glycans are critical for mammalian biology at a fundamental level

There is a pervasive view of glycobiology as a niche field that does not warrant significant attention. This is borne out of a profound ignorance. It is not an exaggeration to state that carbohydrates are just as important as proteins, nucleic acids, and lipids. Dismissing the impact of glycans is like stating that proteins are not very important to biology, and their importance is seen in the lethality of many mutations ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 1: Promote Human Health

Rejuvenating Old Hearts and Lungs

Is there a true "mechanome" affecting normal heart function that could be studied to uncover important mechanically-stimulated pathways relevant to tissue development, maintenance, and repair in vivo? Are there mechanomics that predict and control fundamental biological processes linked to the body's natural healing and regeneration machinery? What if we could leverage 3D tissue engineering advances to rejuvenate aging ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 1: Promote Human Health

Basic research in glycobiology is urgently needed

There are two areas in which glycobiology has been very successful: technology development and disease correlation. Through efforts exemplified by the CFG, major strides in mass spectroscopy and the creation of novel technologies for probing glycan-protein interactions (e.g. glycan microarrays) have been seen. Likewise, the success of the Programs of Excellence in Glycoscience and those of us focused on disease have also ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 1: Promote Human Health

Improve understanding of cardiometabolic health in Asian Americans

We are only now beginning to recognize that certain Asian American subpopulations are at high risk for cardiometabolic (CM) disorders thanks to recent ethnicity-specific studies (e.g., MASALA study). For the most part, however, our understanding of CM risk in Asian Americans is based on aggregated data. Further, a perception remains that other, understudied groups (e.g., Chinese Americans) are at low risk because of their ...more »

Submitted by (@mtseng)

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