Goal 2: Reduce Human Disease

To extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.
(@f.despa)

Goal 2: Reduce Human Disease

What pathobiology underlies the interaction of the diabetogenic hormone amylin with vascular media ?

Amylin is synthesized and co-secreted with insulin by pancreatic beta-cells, plays a complex role in peripheral energy homeostasis, and shows also a high propensity to oligomerize when overexpressed (hyperamylinemia). Accumulation of oligomerized amylin is a pathological hallmark of the islet in diabetic patients and induces oxidative stress, inflammation and apoptosis. However, recent studies found significant deposits... more »

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-6 net votes
3 up votes
9 down votes
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(@aabbate)

Goal 2: Reduce Human Disease

Ischemia-independent mechanisms contributing to infarct size

What are the mechanisms of ischemia-independent mechanisms contributing to the infarct size in patients with acute myocardial infarction? Infarct size is the single most important prognostic factor for short- and long-term outcomes. The success in reperfusion strategies have shown that prompt reperfusion leads to a reduction in infarct size, and to improved outcomes. Despite effective reperfusion, however, a secondary... more »

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-2 net votes
6 up votes
8 down votes
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(@pajohnson)

Goal 2: Reduce Human Disease

Decreasing risk for cardiometabolic disorders in pregnancy with a focus on preeclampsia

The prevalence of cardiometabolic disorders of pregnancy are increasing rapidly in women in the United States, particularly in black women. These disorders have a significant impact on the development of CVD in women as they age and on their offspring. The science to answer these questions are both mechanistic(understanding underlying mecanism of disease, esp preeclampsia) and behavioral. New methods of gathering... more »

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1 net vote
3 up votes
2 down votes
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(@aabbate)

Goal 2: Reduce Human Disease

Modulation of cardiac contraction and relaxation in heart failure: role of systemic inflammation

Is cardiac contraction and relaxation in heart failure modulated by the systemic inflammatory response? There is overwhelming evidence that inflammatory biomarkers predict worse outcome in acute and chronic heart failure. Despite the wealth of evidence, clinical trials in this area have either not been completed, failed, or provided inconclusive results. The questions that remain are: 1) Is inflammation a mechanism... more »

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8 net votes
14 up votes
6 down votes
Active
(@ghunninghake)

Goal 2: Reduce Human Disease

Identifying Early Stages of Pulmonary Fibrosis

The majority of translational research designed to improve the lives of patients with pulmonary fibrosis has focused on studies of patients with advanced fibrotic lung disease. In contrast, little effort has been paid to understanding the natural history of pulmonary fibrosis, exploring the mechanisms/pathogenesis of the development of pulmonary fibrosis, and considering work designed to prevent the development of lung... more »

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29 net votes
35 up votes
6 down votes
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(@stephen.fortmann)

Goal 2: Reduce Human Disease

Funding Limitations Block Intervention Research

The cap on R01 research grants at $500,000 per year has not changed in over 20 years. In the current fiscal crisis for research it has become an immovable block to submitting intervention studies (randomized clinical trials on treatment). Routine advice from NIH staff is to not even try for a larger study. The cap applies to every year, so one can design a trial that costs less than $2.5 million but exceeds $500,000 in... more »

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3 net votes
6 up votes
3 down votes
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(@nhlbiforumadministrator1)

Goal 2: Reduce Human Disease

Optimal Use of mechanical circulatory support devices to Minimize Pump Thrombosis & AEs

There is a need for the development of a collaborative observational study that leverages off of existing registries, such as INTERMACS and STS, that will follow mechanical circulatory support devices (mechanical circulatory support device) patients prospectively and collect process-of-care data to identify 1) optimal approaches for the management of patients and 2) pumps to minimize the occurrence of adverse hemodynamic... more »

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4 net votes
15 up votes
11 down votes
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(@dcenter)

Goal 2: Reduce Human Disease

Improve Repair of injured lung

Why can’t we improve outcomes following acute lung injury. A half century of ICU interventions have resulted in only incremental improvements in survival and morbidity following acute lung injury. While we have pursued innumerable strategies for decreasing ventilator associated exacerbation of lung injury, we have failed to identify treatable common or selective pathways from the initial injury that can be targeted post... more »

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5 net votes
8 up votes
3 down votes
Active