the role of pro-inflammatory mechanisms of vascular disease are well characterized, but we know little about potentially protective endogenous anti-inflammatory mechanisms.
Goal 2: Reduce Human Disease
Incorporate important co-morbidities of COPD into treatment guidelines. This becomes crucially important with cardiovascular disease (CVD) which shares risk factors and pathogenesis
What is the most effective way to phenotype (classify) patients with respiratory failure requiring mechanical ventilation?
Effect of anti-inflammatory medications (including nasal steroids and leukotriene antagonists) in children with obstructive sleep apnea syndrome, stratified for severity of OSAS as well as presence of atopy.
There is a need to develop hand-held portable imaging or other technologies that can help paramedics to collect and transmit data when patients are undergoing cardiovascular events.
NHLBI should incorporate more patient input in the institute’s decision-making process and consider more collaboration with the Patient-Centered Outcomes Research Institute.
Society is ageing and chronic degenerative diseases including COPD are increasingly occurring together. The critical question is whether certain diseases occur together by chance or are they occurring together because they share pathobiological commonalities and mechanisms? This leads to a series of practical consequences and questions 1. Which diseases are occurring concurrent with COPD more than chance alone would... more »
Can early warning symptoms and signs of a heart attack (acute coronary syndrome) be quantified through standardized symptom surveys, biochemical measures, electrocardiographic, or other diagnostic means to enable earlier evaluation and treatment?
The notion that in order to be treated with CPAP for sleep apnea you first must have a diagnostic test, which involves either a sleep laboratory or a home study, needs to be examined.
The true prevalence of Nontuberculous mycobacterial (NTM) lung infections remains incompletely understood, however several aspects of NTM lung disease prevalence are becoming more clear. NTM lung disease is currently more common in the U.S. than TB (by a factor of 3) and has consistently been shown to be increasing in prevalence. When viewed in the context of likely universal environmental NTM exposure this increasing... more »
Given that approximately 64 percent of women who died suddenly of CHD had no previous symptoms4 and that traditional risk factors and scores underestimate CHD risk in women, there is a need to identify unique markers for women at risk for CHD60.
( from 10 Report)
How to develop effective medical therapies to reduce aneurysm progression - currently only surgical intervention is effective.
Is there a role for statins and/or ACE-inhibitor medications in patients with more mild COPD who do not present with acute exacerbations?
Can we define the basis for high risk individual’s apparent protection from disease?
What is the role of lung stem/progenitor cells in disease?
Which diseases involve stem cell defects?