Goal 2: Reduce Human Disease

To extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.
(@marilynmoy)

Goal 2: Reduce Human Disease

Promoting Physical Activity in COPD

The GOLD guidelines recommend regular physical activity in all patients with stable COPD. How we operationalize this is completely unclear. We know pulmonary rehab works but few patients are referred and fewer participate. We also know physical activity, not just exercise, directly measured in the field is associated with COPD-specific outcomes such as acute exacerbations, hospitalizations and death. How do we bring ...more »

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4 net votes
5 up votes
1 down votes
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(@jsullivan)

Goal 2: Reduce Human Disease

Prevent the Development of COPD

What can be done to prevent the development of COPD in individuals at increased risk. Quitting smoking before the development of COPD can prevent COPD development. What can be done to prevent COPD for individuals with other identified ris factors

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15 net votes
18 up votes
3 down votes
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(@bavtad)

Goal 2: Reduce Human Disease

Bicuspid aortic valve is not a “one size fits all” condition. Variations exist within families and the population generally.

Clinical disease manifestations in individuals and families where bicuspid aortic valve is present may best be described as a spectrum, with considerable variability in presentation. Patients and families would benefit from an individualized approach, which does include familial medical history, but couples that information with current best understanding of BAV, considering both variations and risks.

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-4 net votes
10 up votes
14 down votes
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(@jiang001)

Goal 2: Reduce Human Disease

What about the impact of regulation of genes in response to external stimulation on human health

We are focusing a lot on the genes that may be protective or harmful to our lives. But what about the regulation of genes in response to external stimulations, such as psychosocial and/or environmental, that are probably more accountable for whether we live healthier or not.

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-4 net votes
5 up votes
9 down votes
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(@nhlbiforumadministrator)

Goal 2: Reduce Human Disease

Psychological & Behavioral Phenotyping to Improve Weight Control

What information is needed to improve our understanding of individual characteristics and processes that explain or predict dietary intake patterns, initiation or sustained engagement in physical activity, and sedentary behavior so that we can improve treatment matching and identify novel targets for more efficacious individual- and population-level approaches for weight management?

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29 net votes
50 up votes
21 down votes
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(@andra.james)

Goal 2: Reduce Human Disease

Mechanisms of Uterine Hemostasis

What are the mechanisms of uterine hemostasis? Endogenous mechanisms of uterine hemostasis protect women from the bleeding challenges of miscarriage, childbirth, and menstruation. Dysregulation of these mechanisms has implications for the critical public health problems of hormonally-induced venous thromboembolism and hormonally-induced arterial thromboembolism (myocardial infarction and stroke). Our current understanding ...more »

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14 net votes
19 up votes
5 down votes
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(@camarell)

Goal 2: Reduce Human Disease

Reduce the immunological burden of Heart Transplantation.

The research in the field of heart transplantation is importantly targeted to minimization of the undue toxicity of immunosuppressive regimens. This practice is limited by the natural tendency to develop chronic and humoral rejection if immunosuppression is too low. Allocation of organs in Heart Transplantation (HTx) is traditionally limited by the logistic of donation (Cold Ischemic Time) and by the urgency of recipients. ...more »

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0 net votes
1 up votes
1 down votes
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(@ckevil)

Goal 2: Reduce Human Disease

Redox regulation of cardiovascular and lung disease through thiols

Redox imbalance as represented by alterations in oxidative versus reductive stresses are well appreciated to occur during nearly all forms of cardiovascular and lung diseases. However, specific molecular mechanisms responsible for these changes remain largely unknown and poorly organized. Study of redox biology principals has revealed that protein cysteine thiols are a unique target for redox posttranslational modifications ...more »

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-5 net votes
5 up votes
10 down votes
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