Goal 2: Reduce Human Disease

To extend our knowledge of the pathobiology of heart, lung, blood, and sleep disorders and enable clinical investigations that advance the prediction, prevention, preemption, treatment, and cures of human disease.

Goal 2: Reduce Human Disease

Submitted by (@csaper)

What are the biological consequences of sleep loss or disruption and how can they best be avoided?

Arousals in obstructive sleep apena (OSA) are life saving, but the associated disruption of sleep is now thought to cause cognitive impairment, increased risk of high blood pressure and atherosclerosis, as well as glucose intolerance and metabolic syndrome. The mechanisms for these downstream effects, however, are not well understood. Can these specific pathophysiological mechanisms be identified, and can ways for mitigating ...more »

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96 net votes
125 up votes
29 down votes
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Goal 2: Reduce Human Disease

Submitted by (@ryandh)

Optimizing weight loss

For patients with obesity and medical comorbidities, what is the optimal approach utilizing multiple therapies (low calorie structured diet, intensive lifestyle, weight loss medications) in combination to optimize weight loss?

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34 net votes
84 up votes
50 down votes
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Goal 2: Reduce Human Disease

Submitted by (@serevill)

Does lowering circulating lipoprotein(a) levels influence cardiovascular outcomes?

A comprehensive research strategy and plan is needed to determine the most efficient, safe, cost-effective and widely applicable strategy to decrease circulating levels of lipoprotein(a) and to determine whether lowering circulating lipoprotein(a) levels will reduce the risk of developing cardiovascular disease such as a heart attack or a stroke as well as the progression of atherosclerosis or aortic stenosis.

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235 net votes
297 up votes
62 down votes
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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

National AICD and resynchronization therapy prospective registry

Emerging data suggest underutilization and variation of care in heart failure patients with ICD defibrillator therapy. Furthermore, there is a lack of data about those who benefit and those who will not benefit, including the role of gender, age and CHF morphology (phenotype).

 

creation of reliable and validated data entered into a registry with cases and controls

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3 up votes
12 down votes
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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator)

Registry of new-onset, post-operative atrial fibrillation

There is a need for an observational registry of new-onset post-operative atrial fibrillation (AF) patients to better understand the mechanisms of post-operative AF and allow clinicians to define patient-specific AF phenotypes and treatments. The registry’s information and infrastructure could be used to develop and conduct clinical trials that provide strong evidence for guidelines in treating this common problem.

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-12 net votes
7 up votes
19 down votes
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Goal 2: Reduce Human Disease

Submitted by (@bmdixon)

What causes the structural abnormalities that cause sleep apnea, and how can they be prevented?

It is estimated that up to 28% of the population suffer from sleep apnea, which impairs functioning and reduces quality of life, while increasing risk of accidents and a variety of cardiovascular, metabolic, and neuropsychiatric diseases. A large portion of sleep apnea cases are caused by abnormal oro-nasal-maxillo-mandibular features that result in crowding of the upper airway, making it vulnerable to collapsing or ...more »

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6 net votes
44 up votes
38 down votes
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