Goal 3: Advance Translational Research

To facilitate innovation and accelerate research translation, knowledge dissemination, and implementation science that enhances public health.

Goal 3: Advance Translational Research

Tissue engineered constructs for vascular disease

Can we develop improved, clinically effective tissue engineered constructs for vascular disease?

Submitted by (@societyforvascularsurgery)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

We need a better alternative to coronary and lower extremity bypass surgery for patients lacking adequate vein.

Name of idea submitter and other team members who worked on this idea : Society for Vascular Surgery

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1 net vote
2 up votes
1 down votes
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Goal 3: Advance Translational Research

Smoking Cessation Programs for the Patient with COPD

What barriers and facilitators modify the effectiveness of smoking cessation programs in patients with COPD?

Submitted by (@k.willard)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

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12 net votes
15 up votes
3 down votes
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Goal 3: Advance Translational Research

Identification of autoantigens that elicit pathogenic immune responses in cardiovascular diseases

Pathogenic immune responses participate in the pathogenesis of many cardiovascular diseases. However, the autoantigens and foreign antigens that elicit the pathogenic immune responses have been poorly identified. Currently, the regulatory mechanisms on immune responses associated with diseases got some attentions. But, without detailed characterizations of this wide spectrum of autoantigens and foreign antigens in patients ...more »

Submitted by (@xfyang)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Feasibility and challenges of addressing this CQ or CC :

1) use peptide/protein based microarray to antibody autoimmune responses associated with each major cardiovascular diseases;

2) use MHC tetra-mers or similar techniques to characterize T cell autoimmune responses associated with each major cardiovascular diseases;

3) determine autoantigen repertoire changes in patients' responses to current therapies, especially therapies with immune modulating effects;

4) develop autoantigens-based immune therapies for clinical trials

Name of idea submitter and other team members who worked on this idea : Professor Xiaofeng Yang, MD, PhD, Professor Hong Wang, MD, PhD, Professor Klaus Ley, MD

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26 net votes
28 up votes
2 down votes
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Goal 3: Advance Translational Research

Access to healthcare for treatment/management of asthma and allergies, and funding of research on asthma and allergies

It is essential that people with asthma and allergies have access to affordable, quality healthcare for the treatment and management of asthma and allergies, and that research is funded to address prevention, screening, and lifestyle interventions to reduce the incidence and adverse effects of asthma and allergies. These conditions impose significant costs on the overall health care system and on patients and their families. ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Currently, more people than ever are struggling to live normal and healthy lives in the face of the daily limits that asthma and allergic diseases create. More than 25 million Americans have asthma, 15 million have food allergies, and 50 million have other allergic conditions. AAFA urges the National Institutes of Health (NIH) to continue to focus and accelerate research on asthma and allergies, which are life threatening chronic conditions for which there are no cures.

 

While asthma affects all populations, the burden of asthma falls disproportionately on the black and Hispanic/Latino—largely Puerto Rican—populations, and especially on minority children. Asthma is the third leading cause of hospitalization among children under the age of 15 and is a leading cause of school absences from chronic disease – accounting for over 10.5 million lost school days in 2008. Asthma costs our healthcare system over $50.1 billion annually and indirect costs from lost productivity add another $5.9 billion. Asthma claimed the lives of more than 3,400 Americans in 2010. According to the American College of Allergy, Asthma & Immunology, allergic diseases, which include asthma, are the fifth most prevalent chronic diseases in all ages, and the third most common in children.

Name of idea submitter and other team members who worked on this idea : Asthma and Allergy Foundation of America (AAFA)

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1 net vote
1 up votes
0 down votes
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Goal 3: Advance Translational Research

Telemonitoring and COPD Exacerbations

What is the effectiveness of the telemonitoring system to detect and trigger treatment for COPD exacerbations?

Submitted by (@abryan)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

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7 net votes
8 up votes
1 down votes
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Goal 3: Advance Translational Research

Does non-invasive ventilation (Bi-Pap) improve quality of life and muscle health in FSHD patients

What is the difference in quality of life and functioning in adult facioscapulohumeral muscular dystrophy patients who are on non-invasive ventilation Bi-Pap versus age matched FSHD patients not on ventilation in a long term longitudinal study?

Submitted by (@daniel.perez)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

There is an unmet need for the NHLBI to foster basic, preclinical and clinical research on the pulmonary consequences of respiratory insufficiency, and specifically with hypercarbic (high CO2) respiratory insufficiency, in facioscapulohumeral muscular dystrophy (FSHD) and other adult muscular dystrophies.

Feasibility and challenges of addressing this CQ or CC :

The adult muscular dystrophies have received insufficient attention, both from research and clinical practice perspectives. As with cardiomyopathy and arrhythmia, currently little data is available as to how to best measure/monitor, and when and how to intervene in, the respiratory complications of the adult muscular dystrophies (FSHD, DM, LGMD) using respiratory therapy, non-invasive ventilation (bi-Pap, Trilogy) or ventilation. The absence of home-based sleep studies and technologies to easily assess hypercapnia are identified as a significant gap in knowledge. Additionally, since the cardiac and pulmonary hypercarbic respiratory insufficiency complications are inextricably linked, studies of the interrelationship between cardiac and pulmonary consequences of the muscular dystrophies (congestive heart failure, pulmonary hypertension) are needed, and interdisciplinary teams of researchers may be best equipped to conduct them.

Name of idea submitter and other team members who worked on this idea : FSH Society

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-9 net votes
8 up votes
17 down votes
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Goal 3: Advance Translational Research

Obesity in special needs populations: Congenital heart disease

What are effective prevention and treatment strategies for populations with special needs, such as those with congenital heart disease, Down syndrome and preterm-born, to maintain a healthy weight?

Are there successful strategies derived from "normal" populations that could be effectively applied to these populations?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Children and individuals with special health conditions or needs are often excluded from participating in obesity treatment and prevention studies at the individual, group and community level. By answering this question, we would anticipate improving health, reducing future CV risks, increasing quality of life and decreasing already substantial healthcare costs in special needs populations.

Feasibility and challenges of addressing this CQ or CC :

1. We are beginning to understand which strategies appear effective in healthy overweight/obese populations, which could be leveraged for studies and interventions in special populations. 2. Adequate populations exist to address this CC: There are now more adults than children living with congenital heart disease, nearly 50% overweight or obese. Among these, individuals with Down syndrome are disproportionately overweight and have metabolic dysfunction. Preterm-born adults are more likely to be overweight/obese, have increased BP and other CV risks compared to term-born adults. 3. The Research Plan for Down Syndrome (NICHD) lists "obesity" in its short term research objectives.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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-24 net votes
12 up votes
36 down votes
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Goal 3: Advance Translational Research

Harnessing the ongoing ‘natural experiments’ of quality improvement

How do we harness the ongoing “natural experiments” of quality improvement (QI) activities in various healthcare systems to facilitate hypothesis-driven research, improve scientific validity to address questions in clinical trials, and implement and disseminate research results? • Current restrictions in human subjects research regulations • Diversity in approaches and methodology rigor to QI initiatives across different ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

• Publication of QI initiatives in peer-review journals

• Wider dissemination and adoption of best practices

• Establishment of methodologically rigorous QI programs with viable career pathways

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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-2 net votes
11 up votes
13 down votes
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Goal 3: Advance Translational Research

Can SYK or BTK inhibition ameliorate autoimmune hemolytic anemia after stem cell transplantation

Experimental mouse models of ITP and AIHA are dependent on FcgR-signaling, which in turn depends on Syk kinase activity for activation of phagocytes. A significant and refractory complication of stem cell transplantation is immune hemolytic anemia. This can be either autoimmune or alloimmune. In either case it is likely that clearance of RBC and RBC progenitors is dependent on extravascular mechanisms involving activation ...more »

Submitted by (@jantin)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Autoimmune hemolytic anemia occurs in about 5% of allogeneic stem cell transplants as a late immunologic complication of immune dysregulation. This occurs either in the setting of chronic GVHD or independently. ABO incompatibility also results in hemolytic anemia which may be complicated by transplant-related mortality or pure red blood cell aplasia. Often ABO incompatible donors are the only option. Targeting of FcgR has not been assessed in this setting and would 1) provide clinical benefit, 2) shed light on the role of FcgR inhibition in a more general way in BMT-related complications.

Feasibility and challenges of addressing this CQ or CC :

This interesting question can best be addressed in the context of a network study, since the development of AIHA is uncommon. BMT-CTN would be a superb mechanism to assess feasibility and efficacy and it would be well-positioned to study scientific offshoots of this approach.

Name of idea submitter and other team members who worked on this idea : Joseph Antin

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23 net votes
52 up votes
29 down votes
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Goal 3: Advance Translational Research

Can we leverage exisiting registries to perform prospective trials and advance reduce the cost of doing research?

Current costs for multicenter randomized or non randomized trials are astronomical, and a major obstacle to rapid implementation of potential lifesaving discoveries. In the field of hematopoietic cell transplantation (HCT) their is a federal mandate to have a treatment outcome registry. Funds should be made available to leverage that registry to perform prospective trials either randomized or not since HCT programs need ...more »

Submitted by (@giralts)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

This would allow for rapid exploration of novel concepts. Would reduce the time and cost of doing research in the HCT field. Would allow to explore questions related to best supportive care practices in HCT

Feasibility and challenges of addressing this CQ or CC :

Very feasible. Last year we prepared a proposal in response to an RFA demonstrating that all elements are in place.

The CIBMTR has already shown that prospective observational studies are feasible and useful

Name of idea submitter and other team members who worked on this idea : sergio giralt

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123 net votes
154 up votes
31 down votes
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Goal 3: Advance Translational Research

Efficient Evidence-Based Practice

How can we most efficiently utilize limited resources/manpower to facilitate adherence to evidence-based practices and enhance public health?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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5 net votes
14 up votes
9 down votes
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Goal 3: Advance Translational Research

facilitate journal submissions by creating a common submission template

To increase the efficiency of getting timely findings published and to decrease the administrative busywork of learning formatting requirements of each journal for each new submission and of reformatting manuscripts for submission to a new journal. Although this may only take a day or 2 to do, multiplied by thousands of investigators and by all their publications each year this administrative time adds up and takes away ...more »

Submitted by (@lindapeterson)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Formatting and especially reformatting journal submissions to fit different journal specifications (if a manuscript (MS) isn't accepted at the first journal) takes time, which decreases the efficiency of getting new translational (and all) scientific findings published. If the NHLBI could partner with e.g., cardiology journals to develop a common app. at least for the first submission, this would decrease the amount of administrative busywork needed to reformat MSs and improve efficiency of publication. This would be akin to the "Common Application" used by many colleges, which has increased ease and competitiveness of the applications and decreased formatting time. After acceptance a MS could be formatted according to the journal specs.

Feasibility and challenges of addressing this CQ or CC :

Challenge would be to have the journals agree on a common application format.

Name of idea submitter and other team members who worked on this idea : Peterson

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1 net vote
7 up votes
6 down votes
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