Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.
(@rogerjahnke)

Goal 1: Promote Human Health

Qigong and Tai Chi for Chronic Disease Prevention

Non-pharmacological interventions for pain and stress have gained tremendous momentum. Mind-Body Practice -- Qigong and Tai Chi -- are group based and inexpensive to implement. The evidence base suggests that these practices are safe and effective for a multitude of preventable chronic disorders.. THE QUESTION: Given safety and efficacy, should there be vigorous research on implementation of Qigong and Tai Chi and... more »

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2 net votes
33 up votes
31 down votes
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(@akuaban)

Goal 1: Promote Human Health

Venous Thromboembolism

How can individual VTE risk-assessment scoring be combined with promising biomarker candidates in order to help predict risk in the general patient population and prevent unprovoked low-risk VTE cases?

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30 net votes
41 up votes
11 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Hypothermia and hemostasis after severe trauma

There is a need to employ new molecular tools to delineate the difference between beneficial and uncontrolled shock-induced hypothermia, because data on hypothermia and hemostasis are incomplete or lacking, especially on the duration, depth and type of hypothermia.

 

availability of targeted resource grant funding

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-8 net votes
7 up votes
15 down votes
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(@nhlbiforumadministrator1)

Goal 1: Promote Human Health

Studying Health in Addition to Disease

Why do some people stop smoking after a stroke or myocardial infarction, whereas others do not? What motivates people who adopt a healthier diet and exercise program during their lifetime or after a significant health event? How can we promote healthier lifestyle choices at all stages of life? How do we ensure equitable health promoting activities for minorities, vulnerable populations, and lower socio-economic status... more »

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135 net votes
176 up votes
41 down votes
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(@jnoel0)

Goal 1: Promote Human Health

DESIGN AND EVALUATE INTERVENTION STRATEGIES TO IMPROVE SLEEP HEALTH AND CIRCADIAN DISRUPTION

Data indicate the association between short sleep and circadian disruption on a number of adverse outcomes such as cardiovascular disease, metabolic disorders, hypertension, etc. There is a need to move beyond association to interventions that can be shown to improve sleep duration and circadian disruption.

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205 net votes
250 up votes
45 down votes
Active
(@tomiyama)

Goal 1: Promote Human Health

Psychological Stress and Cardiovascular Health

Our new Surgeon General Dr. Vivek Murthy said recently that one of this four rules for health was "...making sure I’m focusing on my emotional and mental well-being." A majority of Americans reporting moderate to high levels of stress (American Psychological Association, 2014), and evidence links psychosocial aspects of stress and cardiovascular health. Therefore, just as Dr. Murthy highlights well-being as a foundation... more »

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24 net votes
33 up votes
9 down votes
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(@nhlbiforumadministrator1)

Goal 1: Promote Human Health

Smart Biomaterials for Self-Adjusting Implants

There is a need to leverage ongoing research on active materials (e.g., self-regenerating body armor, insulin-releasing polymers that respond to glucose, etc.) to stimulate the invention of new materials and constructs that are electrically, chemically and mechanically active to enable self-adjusting bioengineered implants.

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-4 net votes
9 up votes
13 down votes
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(@psaty0)

Goal 1: Promote Human Health

What administrative changes might facilitate team science? Update peer-review and budget mechanisms for team science.

NIH peer-review methods were developed at a time when biomedical science was generally conducted by individual investigators. Approaches to defining conflict of interest in peer review that worked well for individual investigators may not be fit for the review of large-scale collaborative projects. Similarly, the subcontract mechanisms are often slow and cumbersome at a time when projects need to be nimble and timely.... more »

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54 net votes
74 up votes
20 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Basic research in glycobiology is urgently needed

There are two areas in which glycobiology has been very successful: technology development and disease correlation. Through efforts exemplified by the CFG, major strides in mass spectroscopy and the creation of novel technologies for probing glycan-protein interactions (e.g. glycan microarrays) have been seen. Likewise, the success of the Programs of Excellence in Glycoscience and those of us focused on disease have also... more »

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3 net votes
3 up votes
0 down votes
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(@gcioffi)

Goal 1: Promote Human Health

Continued focus on mechanism of Red Cell Production

Recent murine studies and early phase clinical trials demonstrate that pharmacologic “traps” for TGF-beta family members may stimulate erythropoiesis in non-erythropoietin-dependent mechanisms. The molecular details of this process remain to be elucidated. Better understanding of this process, which may markedly decrease the marrow problem of “ineffective erythropoiesis,” may lead to improved therapies in thalassemia,... more »

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47 net votes
57 up votes
10 down votes
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