Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Bypass the CSR and concurrently act to help reform it

A key aspect of making any strategic plan focused upon glycoscience funding effective is the mechanisms by which grants are chosen. The problem is not the IC and making prioritized decisions; the problem is the study section ignorance and bias. Proposals that are reviewed poorly in study section out of flippancy towards glycobiology or simple lack of a critical mass of appropriate expertise never see the light of day ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Feasibility and challenges of addressing this CQ or CC :

In order to truly promote glycobiology at the NHLBI, I would suggest two action items: 1) Heavily rely upon the RFA mechanisms in which the scientific review process is internal to the NHLBI or

special emphasis panel to ensure proper representation of glycobiologists on the panel. The success of this approach can be seen in the NHLBI-funded Programs of Excellence in Glycoscience (PEG), and I would predict similar success with the nascent NIH Common Fund Initiative in Glycosciences.

2) As much as possible, place significant pressure on the CSR to integrate far more glycobiology expertise into all standing study sections. As far as I can tell, any pressure placed on the CSR from the research community has fell upon deaf ears. One glycobiologist on a panel is inadequate.

Name of idea submitter and other team members who worked on this idea : Brian Cobb

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Goal 1: Promote Human Health

What is the potential effect of the burden of COPD on the US workforce?

COPD currently affects approximately 25 million individuals in the US alone, many of whom are of working age, according to the most recent BFRSS data. Many of those people are encouraged by their doctors or families to apply for disability and receive it, even though there are still jobs they could do. This is going to have an impact on business and industry as these people who are at the peak of their careers leave. ...more »

Submitted by (@jmrommes)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

I think if this question were answered and that industry understood the impact of COPD on the potential workforce going forward, there would be significant interest from business and industry to do several things:

prevent COPD; develop accommodations that would allow people with COPD to continue to work; reduce the burden to both industry and individuals with COPD by allowing them to continue to work and produce until planned retirement.

Feasibility and challenges of addressing this CQ or CC :

This would not be a difficult question to answer. More difficult would be the education of both individuals and business and industry in how to accommodate people with COPD so they can continue to work until their planned retirement. Techniques and strategies could be developed, however, benefiting both business and the individual.

Name of idea submitter and other team members who worked on this idea : Jean M. Rommes

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15 up votes
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Goal 1: Promote Human Health

Mechanisms of Vascular Stiffness

Increased vascular stiffness has been identified as an important cardiovascular event that accompanies aging and cardiovascular disease. Although multiple vascular changes have been identified and suggested to cause increased vascular stiffness, our understanding of the underlying mechanisms needs to be refined in order to develop useful therapeutic strategies to prevent or reverse these changes. An example of critical ...more »

Submitted by (@meiningerg)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Ultimately, addressing this CQ would impact treatment of CV disease, reduce incidence of significant and life threatening CV events and improve quality of life. This area of investigation is relevant to therapeutics and potentially lifestyle changes that will improve CV health and slow CV age related changes linked to disease.

Feasibility and challenges of addressing this CQ or CC :

Current advances in our technologies make it very feasible to address new questions to improve our knowledge of the mechanisms underlying vascular stiffness. Challenges will include developing multi-scale and cross disciplinary strategies that will, by design, facilitate an integrated understanding of the process leading to altered vascular stiffness.

Name of idea submitter and other team members who worked on this idea : Gerald A. Meininger

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88 up votes
33 down votes
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Goal 1: Promote Human Health

A Systems Approach - Human Cardiac Electromechanical Activity

The challenge is to identify limitations in using data from non-human animal species for elucidation of human electromechanical function/activity and to identify what specific information and computational approaches need to be incorporated. To aid in achieving such a goal, it might be useful to convene a series of workshops to build consensus and improve communication among investigators working at the same horizontal ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

This will provide an in silico computational platform to study human cardiac pathology. Note: by different horizontal levels, we mean for example measuring and modeling individual ion channels, transporters or myofilament properties in myocytes. By different vertical levels, we mean for example gogenomic/proteomic to cellular, and cellular to more integrative levels.

Feasibility and challenges of addressing this CQ or CC :

Advances in high-speed computation techniques and high-throughput measurement make the achievement of this challenge doable.

An integrated understanding of the eletromechanical activity of the human heart is needed to develop more effective approaches to cardiac disease diagnosis, treatment, and prevention. Robust computational models of human electromechanical activity that incorporate ion channel kinetics, calcium handling and dynamic changes in the intra-/extracellular milieu from human cardiac tissues are needed develop such an understanding and to provide an experimental platform to test interventions designed to maintain cardiac function. Computational models should be scalable and incorporate subcellular molecular mechanisms to whole system levels of integration to be most effective.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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20 up votes
13 down votes
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Goal 1: Promote Human Health

Role of the lymphatic system in heart, lung, blood, sleep health and diseases

What is the role of lymphatic system in normal function of the heart? Do dysfunctional lymphatics contribute to heart failure? Do lymphatics have a role in recovery after MI? It has been reported that lymphatic vasculature transport HDL during reverse cholesterol transfer. Do lymphatics have a role in atherosclerosis? What is the contribution of lymphatic system to asthma or COPD? Does the lymphatic system contribute ...more »

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Understanding how lymphatic system contributes to normal physiology of heart, lung, blood, sleep systems will help also lead to new approaches for treatment of heart, lung, blood, sleep diseases.

Feasibility and challenges of addressing this CQ or CC :

Basic understanding of the development and hemodynamics of the lymphatic system and reagents to study the lymphatic function are available.

Lymphatic vasculature is essential for fluid hemostasis in the body, collects and returns the protein- and lipid-rich interstitial fluid to blood circulation, and also involved in immune cell trafficking and inflammation. Given these important physiological roles, function of the lymphatic system is expected to contribute to normal physiology of organs and its dysfunction to major diseases. There is very little or no information how the lymphatic system contribute to health and diseases of the cardiovascular, pulmonary and blood systems, and there are many unanswered questions. Answers to these questions may lead to new approaches for treatment of major HLB diseases. Main challenge is to get heart, lung, blood, sleep investigators interested in studying the contribution of the lymphatic system to heart, lung, blood, sleep health and diseases.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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77 up votes
27 down votes
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Goal 1: Promote Human Health

Coordination for Cardiac Care: Centalized database and joint sessions

Most senior citizens see a number of doctors. Mostly, coordination among the physicians is limited. Less than perfect to say the least.

Why all the physicians taking care of a patient don't maintain a common central database as well as meet with the patient together- say once a year.

Submitted by (@abasit88)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Better coordination of the physicians and joint sessions with the patient will reduce the duplicity of scans and test. Collaborative approach will lead to more reliable outcomes for the patient and cut the cost of treatment

It will also reduce the incidences of duplicate and contradicting records maintained in the healthcare system.

Feasibility and challenges of addressing this CQ or CC :

Addressing the question of improved coordination among physicians treating a patient is not only feasible and cost effective but it is an absolutely essential step to reduce the healthcare cost, reduce medical errors and significantly improve the patient care.

Name of idea submitter and other team members who worked on this idea : ABDUL BASIT

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Goal 1: Promote Human Health

Human normal variation and resilience across lifespan

What is the measureable normal human variation at the -omic, cellular, organ, and system levels within the population and across the lifespan? • What are the range of normal human cellular functions that create resilience at all levels—cells, organs, organ systems? • What inter-organ, tissue, and cellular communications maintain individual health and the health of populations? • How do we understand why individuals with ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

• Will provide a better definition of what is normal in order to better interpret and exploit the big data available through increased personalized monitoring and use of EMRs.

• Insights into the underlying mechanisms of resilient phenotypes will provide new paradigms for disease prevention and treatment.

Feasibility and challenges of addressing this CQ or CC :

Feasibility will depend on the level of investment (large) and accessibility to commons data.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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26 up votes
7 down votes
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Goal 1: Promote Human Health

ROLE OF HEALTH DISPARITIES IN SLEEP AND CIRCADIAN HEALTH—ENVIRONMENT

Self-report data indicate that insufficient sleep is more common in minority populations. This seems to be related to socioeconomic status. There is a need to move this beyond self-report and obtain objective measures in the relevant populations. Moreover, the basis of this difference needs to be established. What aspect of the environment leads to these differences, e.g., noise, stress related to sense of vulnerability, ...more »

Submitted by (@jnoel0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Self-report indicates that sleep duration is lower in minority populations. This seems to be related to socioeconomic groups. To address this issue requires understanding the basis of this and developing appropriate interventions.

 

The impact of this is as follows:

 

a. Implementing new technology based on mobile approaches to assess sleep duration in subjects in different socioeconomic groups.

b. Developing a comprehensive approach to understanding and evaluating environmental influences in sleep and circadian rhythm.

c. Designing and testing intervention to increase sleep duration in disadvantaged populations.

d. Improving the sleep health of minority populations.

Feasibility and challenges of addressing this CQ or CC :

There is rapidly developing new mobile technology to assess sleep duration and other phenotypes in individuals living in their normal lives. There are a number of studies currently being conducted that could be leveraged to address this question. There are also developing approaches to assess environmental influences on sleep and circadian rhythm such as noise, light exposure, etc. Thus, this question could be addressed in the near future.

Name of idea submitter and other team members who worked on this idea : Sleep Research Society

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173 up votes
51 down votes
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Goal 1: Promote Human Health

Basic understanding on the mechanisms of overeating

We have an in depth understanding of the effects nutrients and diet have on the development of chronic disease, yet very little research funding has gone to understanding the basic mechanisms of eating behavior and how to successful change diet. There are currently no study sections at NIH that specialize in nutrition and/or human eating behavior, and therefore proposals in this subject area get farmed out to other study ...more »

Submitted by (@klk370)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

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Goal 1: Promote Human Health

Obesity and Morbid obesity

Obesity is a pervasive disease. It contributes to serious diseases such as heart, all the way down to cancer. In the past five decades it has been confirmed that the sugar from rich carbohydrate (CHO) foods increases the production of insulin which in turn converts the excess caloric intake into fat. So far neither dieting with highly processed foods rich in CHO’s, nor radical surgery have made a dent in this most ...more »

Submitted by (@baz200)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

This is a fairly new idea of reducing glycemic indices of rich carbohydrate foods which may have an impact on our cultural diets and reduce obesity in children and adults.

Morbidly obese require an additional minimally invasive surgical approach which by GES will be able to curb appetite and produce weight loss.

Feasibility and challenges of addressing this CQ or CC :

The preliminary feasibility studies have been performed in production of lower glycemic index foods such as rice.

US Patent # 8,568,820 B2

Issued October 29, 2013

To turn off the appetite of a hungry canine has been shown in experimental lab by stimulation of the funds of the stomach by pacemaker leads. It requires more experiments to create the sophisticated pacer with many parameters which would be controllable by radio frequency waves from outside. The minimally invasive operation would be performed by laproscopy.

United States Patent # 6,564,101

Issued May 13, 2003

Name of idea submitter and other team members who worked on this idea : Prof. B.A. Zikria, MD, FACS (Emeritus)

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Goal 1: Promote Human Health

Developing predictive models

The need for sophisticated analytic methods to address multidimensional data to facilitate the development of predictive models.

Submitted by (@rebecca.lehotzky)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : AHA Staff & Volunteers

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Goal 1: Promote Human Health

Continuous blood pressure and outcomes monitoring

Currently technology exists for continuous, non-invasive, insertable (not breaking any skin), blood pressure monitoring. At the same time micro-vascular health and whole body inflammatory response can be monitored continuously. The challenge is for the integration of these technologies into a simple device so we can begin to produce long term data on genetic and environmental influences on outcomes.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Blood pressure monitoring via a pressure cuff has been shown to miss many of the problems with elevated blood pressure (e.g. morning surge, normotensive salt sensitivity). Continuous monitoring of blood pressure while measuring micro-capillary health will enable feedback control of the inflammatory events surrounding hypertension, salt sensitivity and related diseases.

Feasibility and challenges of addressing this CQ or CC :

At least three companies are producing research grade products for wearable continuous blood pressure monitoring. The Qualcomm X Prize has yielded several technologies that could continuously monitor microvascular health (e.g. inflammation). We have developed a genetically driven decision tree that will enable physicians can classify their patients into one of 6 cardiovascular types. Each type has a personalized therapy, many of which rely on dietary instead of pharmaceutical treatment. Thus, we need to move cardiovascular diagnosis and therapies into the modern wellness age of medicine.

Name of idea submitter and other team members who worked on this idea : Robin A Felder

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