Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.
(@klk370)

Goal 1: Promote Human Health

Basic understanding on the mechanisms of overeating

We have an in depth understanding of the effects nutrients and diet have on the development of chronic disease, yet very little research funding has gone to understanding the basic mechanisms of eating behavior and how to successful change diet. There are currently no study sections at NIH that specialize in nutrition and/or human eating behavior, and therefore proposals in this subject area get farmed out to other study ...more »

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-3 net votes
17 up votes
20 down votes
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(@nhlbiforumadministrator)

Goal 1: Promote Human Health

The Human Virome and Host Interactions in Heart, Lung, and Blood

What are the unknown elements of the human virome, and what host-virome interactions affect the heart, lung, and blood health and diseases? A major challenge has been the need for in vitro culture systems and animal models for studying the virome, which is a significant limitation that has forced current studies of the virome to be mostly descriptive. NHLBI has supported one research group to identify human virome and ...more »

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13 net votes
29 up votes
16 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

Bypass the CSR and concurrently act to help reform it

A key aspect of making any strategic plan focused upon glycoscience funding effective is the mechanisms by which grants are chosen. The problem is not the IC and making prioritized decisions; the problem is the study section ignorance and bias. Proposals that are reviewed poorly in study section out of flippancy towards glycobiology or simple lack of a critical mass of appropriate expertise never see the light of day ...more »

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1 net vote
1 up votes
0 down votes
Active
(@jnoel0)

Goal 1: Promote Human Health

ELUCIDATING BASIC MECHANISMS OF SLEEP DEFICIENCY AND CIRCADIAN DISRUPTION ON HEALTH THROUGH THE LIFESPAN

There are developing data from clinical studies that sleep deficiency and circadian disruption have multiple adverse consequences for health. The clinical data provide the base for mechanistic studies. Studies in animal models indicate that both circadian disruption and insufficient sleep later gene expression in peripheral tissues. Moreover, the effect of sleep loss in molecular changes in brain changes with age. ...more »

Voting

174 net votes
230 up votes
56 down votes
Active
(@hvd000)

Goal 1: Promote Human Health

Understanding Individual Differences in Responses to Sleep Loss

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to ...more »

Voting

124 net votes
171 up votes
47 down votes
Active
(@nhlbiforumadministrator)

Goal 1: Promote Human Health

What is the role of the environment in HLB disease etiology

It is clear that genetic sequence variation does not account for a substantial portion of disease burden. It is likely that the broad environment contributes to HLB disease via epigenomic alterations and interaction with genetic variants. There is an urgent need to understand the environmental contribution to disease as most exposures are modifiable and are targets for prevention interventions.

Voting

4 net votes
11 up votes
7 down votes
Active
(@nhlbiforumadministrator1)

Goal 1: Promote Human Health

Transforming Transplantation with RISC

What is necessary to reprogram the immune system to improve transplant outcomes of hearts, lungs, and hematopoietic cells? While NIAID is a major funder of immunology research, we are a major contributor to stem cell research. Our resources could be combined, where NIAID would support this approach for autoimmune diseases, and we would support work in tolerance for transplants. If the NCI also wants to collaborate on ...more »

Voting

-3 net votes
15 up votes
18 down votes
Active
(@jnoel0)

Goal 1: Promote Human Health

Identify genetic variants of sleep/circadian disorders

Most aspects of variation in sleep and circadian rhythm are heritable. Moreover, all common sleep disorders aggregate in families. The response to sleep loss is also a highly heritable trait. Identifying gene variants for these disorders will elaborate new molecular pathways that could be targets for future interventions.

Voting

84 net votes
117 up votes
33 down votes
Active
(@jdc000)

Goal 1: Promote Human Health

Early Life Elements

What are the early life elements that contribute to the development of chronic lung disease? Strategies need to be developed for treatment/prevention of these elements.

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5 net votes
16 up votes
11 down votes
Active
(@jalees)

Goal 1: Promote Human Health

Achieving Excellence in Health and Science Communication

At least two thirds of US adults use the internet to access health information. The accuracy and quality of health and science information found on news media websites, corporate websites of the healthcare industry, blogs of healthcare providers and social media networks varies widely. Nevertheless, this information can have a profound influence on the healthcare-related decision-making of patients. The anti-vaccination ...more »

Voting

5 net votes
5 up votes
0 down votes
Active
(@meiningerg)

Goal 1: Promote Human Health

Mechanisms of Vascular Stiffness

Increased vascular stiffness has been identified as an important cardiovascular event that accompanies aging and cardiovascular disease. Although multiple vascular changes have been identified and suggested to cause increased vascular stiffness, our understanding of the underlying mechanisms needs to be refined in order to develop useful therapeutic strategies to prevent or reverse these changes. An example of critical ...more »

Voting

55 net votes
88 up votes
33 down votes
Active