Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Achieving accurate and valid dietary assessment for implementing precsion prevention

Combine objective measures and biomarkers of dietary intake to identify dietary deficiencies/excesses that contribute to risk for cardiometabolic diseases. Technological, statistical and methodological advances in diet assessment are increasingly making it possible to identify the nutrients/phytochemicals/ that contribute to risk factor development in individuals and populations. Interdisciplinary studies are needed to ...more »

Submitted by (@lvanhorn)

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Goal 1: Promote Human Health

Functional and high throughput screening assays

There is a need to develop functional assays and high throughput screening to develop probes and potential drug therapies. A. Functional Assays. Researchers face a challenging gap between identifying many sequence variations of potential interest and recognizing which of these variations have a direct functional effect on the physiological system of interest, as opposed to merely being associated with the actual causal ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 1: Promote Human Health

Psychological Stress and Cardiovascular Health

Our new Surgeon General Dr. Vivek Murthy said recently that one of this four rules for health was "...making sure I’m focusing on my emotional and mental well-being." A majority of Americans reporting moderate to high levels of stress (American Psychological Association, 2014), and evidence links psychosocial aspects of stress and cardiovascular health. Therefore, just as Dr. Murthy highlights well-being as a foundation ...more »

Submitted by (@tomiyama)

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Goal 1: Promote Human Health

Crowdsource NIH Funding

Congress doesn't seem to "get it" regarding the return on investment for biomedical research, but maybe the public does. Create a mechanism whereby individuals can donate directly to the NIH to support research in specific areas (or provide general support).

Submitted by (@jhagood)

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Goal 1: Promote Human Health

The Human Virome and Host Interactions in Heart, Lung, and Blood

What are the unknown elements of the human virome, and what host-virome interactions affect the heart, lung, and blood health and diseases? A major challenge has been the need for in vitro culture systems and animal models for studying the virome, which is a significant limitation that has forced current studies of the virome to be mostly descriptive. NHLBI has supported one research group to identify human virome and ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 1: Promote Human Health

Rejuvenating Old Hearts and Lungs

Is there a true "mechanome" affecting normal heart function that could be studied to uncover important mechanically-stimulated pathways relevant to tissue development, maintenance, and repair in vivo? Are there mechanomics that predict and control fundamental biological processes linked to the body's natural healing and regeneration machinery? What if we could leverage 3D tissue engineering advances to rejuvenate aging ...more »

Submitted by (@nhlbiforumadministrator)

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