Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Lung Repair and Regeneration

What characteristics define progenitor lung cell niches? What controls proliferation and differentiation of lung progenitor cells in normal repair? Can endogenous repair mechanisms and alterations of progenitor cell cycle be harnessed to promote regeneration?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

10 net votes
22 up votes
12 down votes
Active

Goal 1: Promote Human Health

Theoretical division of NHLBI

Many functional physiology, cellular physiology , electrophysiology, and other aspects are amenable to rigorous mathematical methods.NHLBI lacks a theoretical division where IDEAS expressed mathematically make testable predictions at multi scale levels. NHLBI LACKS A THEORETICAL DIVISION- although history has shown that virtually all original ideas have a mathematically expressible foundation, particularly when dynamic, ...more »

Submitted by (@sjk000)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

the impact is obvious in the sense that predicton based on theory can lead to new discovery

Name of idea submitter and other team members who worked on this idea : Sandor j Kovacs

Voting

-13 net votes
12 up votes
25 down votes
Active

Goal 1: Promote Human Health

ORAL HEALTH AND HEART TREATMENT

Compelling Question:

It is very well established now that oral health, particularly gingavitis, play a significant role in cardiac health.

Why this reality is not considered as integral part of Cardiac care?

Submitted by (@abasit88)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

It is expected that incorporating Oral Bacterial ailments such as Gingivitis for cardiac care will more than pay for itself. It will significantly improve the cardiac event prognoses and CUT THE COST OF CARDIAC CARE.

Feasibility and challenges of addressing this CQ or CC :

It is quite feasible and practically possible to incorporate Gingivitis or other serious bacterial oral health problems as integral part of the work of a Cardiologist.

CHALLENGES: Researching the contribution of Oral bacterial issues such as Gingivitis as compared to smoking, obesity and cholesterol levels.

My hypothesis is that Chronoc Oral Bactrial diseases are significant contributors to cardiac problems.

Name of idea submitter and other team members who worked on this idea : Abdul Basit, Ph. D.

Voting

7 net votes
14 up votes
7 down votes
Active

Goal 1: Promote Human Health

Mapping the Vasculome

What is the best method to develop an integrated map of the expression patterns of the vasculature (RNA, protein, and epigenome) within each organ system?

 

Sampling standards and quality control are major outstanding issues.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

The vasculome is comprised of a vast network of vessels that globally interacts with all of the other organ systems within the body. Disorders of the vasculature have a significant adverse effect on those organ systems and are a major source of mortality and morbidity. Systematic mapping of vasculome expression will reveal disease causality patterns that have thus far been unobserved.

Feasibility and challenges of addressing this CQ or CC :

The tools are available, the coordination is not. The NHLBI and VBHB have the expertise, the experience, and the leadership necessary to oversee the multiple studies, date collections, and organizational systems needed for mapping the vasculome.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

3 net votes
12 up votes
9 down votes
Active

Goal 1: Promote Human Health

Improve understanding of cardiometabolic health in Asian Americans

We are only now beginning to recognize that certain Asian American subpopulations are at high risk for cardiometabolic (CM) disorders thanks to recent ethnicity-specific studies (e.g., MASALA study). For the most part, however, our understanding of CM risk in Asian Americans is based on aggregated data. Further, a perception remains that other, understudied groups (e.g., Chinese Americans) are at low risk because of their ...more »

Submitted by (@mtseng)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Decisions regarding public health programming, education, and resources are based on an assumed understanding of cardiometabolic health/risk in Asian American populations rather than on existing, high quality, epidemiologic evidence. Addressing this CQ would provide necessary surveillance/monitoring information for appropriate targeting of resources and it would point to important contextual or individual level determinants to be targeted for programming or intervention.

Feasibility and challenges of addressing this CQ or CC :

This CQ is entirely feasible using established epidemiologic methods although new recruitment methodologies might be necessary to reach broad, population-based samples. The primary obstacle is in recognizing this as a significant public health issue.

Name of idea submitter and other team members who worked on this idea : Marilyn Tseng

Voting

1 net vote
5 up votes
4 down votes
Active

Goal 1: Promote Human Health

Lung Microbiome and Innate Immunity

How does the lung microbiome shape its innate immunity? Is there a commensal immune system in the lung? Is the lung microbiome metabolically active?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

9 net votes
19 up votes
10 down votes
Active

Goal 1: Promote Human Health

Understanding Individual Differences in Responses to Sleep Loss

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to ...more »

Submitted by (@hvd000)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Addressing this CQ is a sine-qua-non for individualized medicine. Especially in the case of physiological and long-term health responses to sleep loss, the differential vulnerability trait and the underlying mechanisms are not well characterized. However, as seen in the cognitive domain, investigating individual differences can help elucidate the underlying mechanisms. Thus, this should be a fruitful line of research not only in the context of individual differences per se, but also for better understanding the link(s) between sleep loss and adverse health outcomes in general.

Feasibility and challenges of addressing this CQ or CC :

This CQ can be addressed by adopting a systems (neuro)biology approach in which individual differences are considered at the systems components level rather than the whole organism level. For example, the task-dependence of individual differences in vulnerability to cognitive impairment due to sleep loss may be investigated at the level of neuronal circuits that subserve performance of the task at hand, rather than at (or in conjunction with) the whole brain / genetic level. A significant challenge in this regard is that in the case of physiological and health responses to sleep loss, the differential vulnerability trait and the underlying mechanisms are not yet well characterized. See "Details On The Impact Of Addressing This CQ".

Name of idea submitter and other team members who worked on this idea : 1

Voting

124 net votes
171 up votes
47 down votes
Active

Goal 1: Promote Human Health

Continuous blood pressure and outcomes monitoring

Currently technology exists for continuous, non-invasive, insertable (not breaking any skin), blood pressure monitoring. At the same time micro-vascular health and whole body inflammatory response can be monitored continuously. The challenge is for the integration of these technologies into a simple device so we can begin to produce long term data on genetic and environmental influences on outcomes.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Blood pressure monitoring via a pressure cuff has been shown to miss many of the problems with elevated blood pressure (e.g. morning surge, normotensive salt sensitivity). Continuous monitoring of blood pressure while measuring micro-capillary health will enable feedback control of the inflammatory events surrounding hypertension, salt sensitivity and related diseases.

Feasibility and challenges of addressing this CQ or CC :

At least three companies are producing research grade products for wearable continuous blood pressure monitoring. The Qualcomm X Prize has yielded several technologies that could continuously monitor microvascular health (e.g. inflammation). We have developed a genetically driven decision tree that will enable physicians can classify their patients into one of 6 cardiovascular types. Each type has a personalized therapy, many of which rely on dietary instead of pharmaceutical treatment. Thus, we need to move cardiovascular diagnosis and therapies into the modern wellness age of medicine.

Name of idea submitter and other team members who worked on this idea : Robin A Felder

Voting

-1 net votes
11 up votes
12 down votes
Active

Goal 1: Promote Human Health

smoking cessation in rural and special populations

We are concerned about access to smoking cessation programs in populations that are hard to reach (rural) and who have other challenges (underserved/marginalized populations including people with serious mental illness). What kind of computer-based or mobile health technologies can assist these groups?

Submitted by (@anna.adachimejia)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : Anna Adachi-Mejia for colleagues at Dartmouth

Voting

1 net vote
1 up votes
0 down votes
Active

Goal 1: Promote Human Health

Nefarious substances in the US blood supply

Prescription and illicit drug is everpresent in the US, which can potentially result in controlled substances entering the US blood supply. Passive transfer of immune allergens is only anecdotally been reported as peanut allergens, fish allergens, and contrast material. However, US blood donors are only screened for a limited number of medications on the universal donor health questionnaire at time of collection. What, ...more »

Submitted by (@garrett.s.booth)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Of the nearly 15 million blood products collected in the US (National Blood Collection and Utilization Survey), what percent of donations capture additional substances like medications and illicit substances. Healthcare providers may be unaware of potential adverse transfusion reactions that could arise from potent allergens within the products themselves.

If additional donor screening is required to reduce the number of medications/drugs entering the US blood supply, how best to do this? Via blood toxicology, urine toxicology, hair toxicology? Is there a need to marry the donor drug history with the recipient allergy list?

Feasibility and challenges of addressing this CQ or CC :

These questions would require blood collection centers to potentially revise how they screen blood donors. How and when to probe donations or donors will require extensive medical-legal investigation.

Name of idea submitter and other team members who worked on this idea : LostInNashville

Voting

-11 net votes
6 up votes
17 down votes
Active

Goal 1: Promote Human Health

Make the food industry not market or develp any more unhealthy foods

Encourage or incntive the food industry to produce healtier food

Submitted by (@jrmerrin)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Voting

-2 net votes
7 up votes
9 down votes
Active

Goal 1: Promote Human Health

Maternal Sleep and Infant Health

How does maternal sleep health contribute to normal utero/fetal development and programming of heart, lung, and blood tissues?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

46 net votes
62 up votes
16 down votes
Active