Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

A Systems Approach - Human Cardiac Electromechanical Activity

The challenge is to identify limitations in using data from non-human animal species for elucidation of human electromechanical function/activity and to identify what specific information and computational approaches need to be incorporated. To aid in achieving such a goal, it might be useful to convene a series of workshops to build consensus and improve communication among investigators working at the same horizontal ...more »

Submitted by (@nhlbiforumadministrator)

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Goal 1: Promote Human Health

Glycans are critical for mammalian biology at a fundamental level

There is a pervasive view of glycobiology as a niche field that does not warrant significant attention. This is borne out of a profound ignorance. It is not an exaggeration to state that carbohydrates are just as important as proteins, nucleic acids, and lipids. Dismissing the impact of glycans is like stating that proteins are not very important to biology, and their importance is seen in the lethality of many mutations ...more »

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Goal 1: Promote Human Health

Individually-Tailored Approaches to Manage Perinatal Weight Gain to Improve Maternal and Infant Health

Managing perinatal weight gain is a major challenge in research and practice. More women enter pregnancy already overweight or obese which increases the risks for morbidity and mortality for both mother and baby. Novel strategies are needed to effectively manage weight gain in this population. This may include infusing engineering principles and dynamical modeling to better understand the complex interactions of biological ...more »

Submitted by (@dsd110)

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Goal 1: Promote Human Health

Simplify cancer survivor followup

Excellent work has been done by Childrens Oncology Group and Childhood Cancer survivor group and the late effects of cancer treatment ,especially in children but also young adults is an ongoing field of study. However protocols for follow up studies ,which should be done and how often and by whom are very complicated and hard to follow. My idea is to develop a simple, relatively inexpensive and user friendly,protocol ...more »

Submitted by (@churv0)

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Goal 1: Promote Human Health

Using video to replace the boring highly ineffective drug monographs that accompany prescrptions

Estimates are that less than 2% of medication monographs are actually read by patients. Of those 2% only 35% fully comprehend the material. Why not use video and simpler methods to educate patients about their medicine. By coding QR tags to direct patients to education websites, we solve the drive through phenomena, the health literacy issue, and the language barrier.

Submitted by (@dburand)

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Goal 1: Promote Human Health

How do Circulating Precursor Endothelial Cells contribute to newly formed vessels

Endothelial cells derive from cells in the bone marrow. Circulating precursor endothelial cells contribute to newly forming vessels.

Do Alk 1 and/or Endogln mutations affect the functions of these cells once they incorporate into growing vessels. These vessels then go on to form arteriovenous malformations

Submitted by (@mariannes.clancy)

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Goal 1: Promote Human Health

Reporting disaggregated data by sex

There is a need to better understand the biological basis for sex differences, particularly for identifying important basic factors that influence normal cardiovascular function and cardiovascular disease in males or females and explain differences in the overall prevalence, progression, and mechanism of cardiovascular disease.

Submitted by (@nhlbiforumadministrator)

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