More effective strategies for community-based participatory dissemination and implementation of research initiatives in rural settings.
Need to develop and integrate biomarkers of asthma into phenotype/endotype-driven asthma management algorithms
Prevention trials, implemented to reduce or delay progression to overt disease in a population at risk to the disease, are an important approach to health promotion. Therapies shown to reduce disease severity in patients with a specific disease are obvious, but not the only, candidates for a prevention trial in populations at high risk for prevalent diseases (such as heart failure, diabetes, COPD, asthma in children). ...more »
Prospective studies on acetaminophen and asthma - randomized/controlled/adequately powered - use in pregnancy and asthma development in utero, use in early childhood
As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan:
Will integration of behavior science in clinical research improve effectiveness of interventions for asthma associated with behavioral risk factors?
Molecular mechanism controlling airway hypersensitivity and remodeling
Adequately powered randomized vitD trials - as primary prevention, and after asthma diagnosis
NIH has a major initiative in Precision Medicine, including whole genome sequencing. In contrast to cancer, mutations with large clinical effects are expected to be uncommon in most non-malignant chronic diseases, such as asthma and COPD. Other data types such as gene expression, biomarkers, and micro RNAs must be combined with clinical and imaging phenotyping to advance Precision medicine in non-malignant lung diseases. ...more »
Develop disease modifying treatments for asthma and asthma disease prevention.
How can we improve communication between schools and clinicians in order to develop support systems for children with severe asthma with health disparities?
How can we eliminate inefficiency in medical communication to better serve children with severe asthma?
In the new era of once a day inhalers for Asthma and COPD, there is critical need to determine whether delivery of drugs to the lung at night or day have different therapeutic effects and/or side effect profile.
What factors predict exacerbations in asthma and can they be prevented?