Is there a role for statins and/or ACE-inhibitor medications in patients with more mild COPD who do not present with acute exacerbations?
Compelling Question Text:
What is the comparative effectiveness and cost-effectiveness of community-based vs. hospital-based pulmonary rehabilitation programs?
Integrated healthcare strategies during transitions in COPD care
• What is cost effectiveness of multi-component COPD programs?
• Will early admission to a Pulmonary Rehabilitation program following a hospitalization for COPD reduce the likelihood of readmission within the following year?
• What is the most effective time to implement the transition from hospitalization following a COPD exacerbation admission?
Specific biomarkers to monitor COPD disease activity are needed.
What can be done in primary care settings to increase appropriate provider assessment of the need for oxygen and prescription of LTOT?
What barriers and facilitators modify the effectiveness of smoking cessation programs in patients with COPD?
There are two broad issues that any future clinical trials in COPD need to seriously consider, that of the challenges of timely and efficient subject recruitment and the need to increase the participation of low to middle income countries that experience a disproportionate burden of COPD in evidence generation. My specific suggestions are as follows: 1) Address the optimal medical management of multiple physical and psychological ...more »
Disease modifying COPD therapy
a. Should we be starting therapy earlier in the course of disease?
b. Is there a survival benefit of oxygen therapy for exercise-induced hypoxemia?
How do we generalize our educational efforts such that multiple co-morbidities and their self-care can be addressed?
How can the structure and function lost in COPD be restored?
What is the comparative effectiveness of a Non-invasive vs. Invasive Positive Pressure
Ventilation Protocol for managing acute respiratory failure due to acute exacerbations of COPD
What does early COPD actually look like. This is defined as severe COPD 30 years prior to its manifestation.
Subjects with both COPD and asthma are typically excluded from clinical trials, but they represent an important segment of the chronic airflow obstruction population. Defining this combination diagnosis is difficult, but requiring a significant smoking history (e.g. 10 pack years), chronic airflow obstruction (GOLD stage 2 or greater after bronchodilator), age > 45, and childhood onset of asthma could identify the relevant ...more »
What is the comparative effectiveness and cost effectiveness of counseling plus nicotine replacement vs. counseling plus bupropion vs. counseling plus varenicline on smoking cessation rates, patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations), and COPD and non-COPD morbidity/mortality?
Society is ageing and chronic degenerative diseases including COPD are increasingly occurring together. The critical question is whether certain diseases occur together by chance or are they occurring together because they share pathobiological commonalities and mechanisms? This leads to a series of practical consequences and questions 1. Which diseases are occurring concurrent with COPD more than chance alone would ...more »