There is a need to promote sex balance in research. We know that existing and emerging scientific evidence supports the notion that sex is a major determinant for the development and progression of cardiovascular disease. Thus, expansion of resources for relevant animal models of disease, and the creation of databases that collect sex as a biological variable are important for both pre-clinical and clinical studies.
There is a need to better understand the biological basis for sex differences, particularly for identifying important basic factors that influence normal cardiovascular function and cardiovascular disease in males or females and explain differences in the overall prevalence, progression, and mechanism of cardiovascular disease.
Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to ...more »