Goal 1: Promote Human Health

Reporting disaggregated data by sex

There is a need to better understand the biological basis for sex differences, particularly for identifying important basic factors that influence normal cardiovascular function and cardiovascular disease in males or females and explain differences in the overall prevalence, progression, and mechanism of cardiovascular disease.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Reporting existing data by sex

Feasibility and challenges of addressing this CQ or CC :

The NIH is developing a new policy re: inclusion of both sexes in experimental research

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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Goal 1: Promote Human Health

Understanding Individual Differences in Responses to Sleep Loss

Individuals differ substantially in their physiological, health, behavioral and cognitive responses to sleep loss. Although these differences represent a trait, individuals who are vulnerable in one domain may be resilient in another - few systematic relationships between physiological, long-term health, cognitive and subjective responses to sleep loss have been found. Moreover, within a given domain, vulnerability to ...more »

Submitted by (@hvd000)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Addressing this CQ is a sine-qua-non for individualized medicine. Especially in the case of physiological and long-term health responses to sleep loss, the differential vulnerability trait and the underlying mechanisms are not well characterized. However, as seen in the cognitive domain, investigating individual differences can help elucidate the underlying mechanisms. Thus, this should be a fruitful line of research not only in the context of individual differences per se, but also for better understanding the link(s) between sleep loss and adverse health outcomes in general.

Feasibility and challenges of addressing this CQ or CC :

This CQ can be addressed by adopting a systems (neuro)biology approach in which individual differences are considered at the systems components level rather than the whole organism level. For example, the task-dependence of individual differences in vulnerability to cognitive impairment due to sleep loss may be investigated at the level of neuronal circuits that subserve performance of the task at hand, rather than at (or in conjunction with) the whole brain / genetic level. A significant challenge in this regard is that in the case of physiological and health responses to sleep loss, the differential vulnerability trait and the underlying mechanisms are not yet well characterized. See "Details On The Impact Of Addressing This CQ".

Name of idea submitter and other team members who worked on this idea : 1

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171 up votes
47 down votes
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Goal 1: Promote Human Health

Developing tools and resources for studying sex differences

There is a need to promote sex balance in research. We know that existing and emerging scientific evidence supports the notion that sex is a major determinant for the development and progression of cardiovascular disease. Thus, expansion of resources for relevant animal models of disease, and the creation of databases that collect sex as a biological variable are important for both pre-clinical and clinical studies.

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Develop tools for studying sex differences. It is envisioned that the development of new tools will improve the comparison of males and females used in research and uncover sex-biased facts that protect from disease, such as if being of the male sex protects from pulmonary arterial hypertension. Additionally, improved tools and training will better enable the researcher to ask important clinical questions, such as whether acute estrogen therapy improves clinical outcomes in post-MI males. Further, unmet clinical needs where sex differences may predominate and influence disease outcome, such early menopause or microchimerism, may be more readily undertaken and tracked. By creating more reliable and user-friendly databases, the quality and quantity of evidence-based medicine should increase and thereby improve, clinical decision-making for health professionals.

Feasibility and challenges of addressing this CQ or CC :

The NIH is in the process of developing new policies for inclusion of both sexes in experimental studies.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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15 net votes
26 up votes
11 down votes
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