What are the biochemical and physiological responses to the acute blood and iron loss that occur during blood donation?
What is the effect of donation-induced iron deficiency on blood donor health?
Is there a risk-based framework for evaluating the blood donor selection process, to capture relevant risk factors for transfusion-transmitted diseases, while modifying policies that do not contribute to transfusion safety?
How can blood centers prevent hypotensive reactions after blood donation?
Are donor factors (age/sex), whole blood processing methods and/or red cell storage solutions associated with in-hospital mortality and/or other measures of transfusion efficacy or harm in patients who have received red cell transfusions?