There is a vast amount of data regarding specific gene and protein targets, especially in the post genomics era with many well validated targets, and even more "strong candidates". Drug companies have libraries of compounds that could be good inhibitors/enhancers for these new targets but lack an internal program, IP of the target, or a sufficiently large market to initiate risky and expensive drug screens, let alone ...more »
Encourage or incntive the food industry to produce healtier food
How do we best develop a scientific workforce that is fluent in product development and commercialization issues? How can NHLBI best expand the training opportunities for early career scientists to prepare them for entry into the dynamic biomedical workforce landscape? There is a need for scientifically-trained experts from diverse backgrounds who also understand business needs relevant to biomedical technology development, ...more »
There is a need to create better alignment between the content of biomedical PhD programs and the careers that actually are available to those who have earned PhDs. Though available data are surprisingly weak, all the evidence suggests that only a small fraction (perhaps 15%) of current biomedical PhDs and postdocs are likely to find stable careers in academic research. Larger proportions are more likely to be employed ...more »
Obesity research is riddled with methodological problems that are rarely challenged, leading to the perpetuation of misinformation and interventions that do harm. Given the two-thirds of the population who are classified as higher weight and thus subject to these interventions, it is past time to clean up the basic scientific flaws in this research area. For a quick summary of a couple of these issues, see Poodle Science: ...more »
There is a need for better collaboration with industry.