Goal 2: Reduce Human Disease

RFA on EC-cardiomyocyte interactions in the mechanisms and treatments of cardiovascular diseases

Often under recognized, the cardiac endothelial cells are highly abundant in the heart, and may have important roles in modulating cardiac function, besides simply serving as structural component of blood vessels. Evidences of ours and others have indicated an emerging role of cardiac endothelial cells signaling to cardiomyocytes to mediate important pathophysiological responses. Nonetheless, detailed mechanisms of ...more »

Submitted by (@hcai00)

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Goal 1: Promote Human Health

Establishment of a Human-Animal Interaction (HAI) research program at NHLBI

NICHD has a human-animal interaction (HAI) research program dedicated to advancing knowledge of the health benefits and therapeutic uses of animals for children, but no comparable program exists for NIH research with adults. As many of the potential health benefits/therapeutic uses of companion animals relate directly to cardiovascular health (e.g., increased physical activity, reduced stress, reduced loneliness), NHLBI ...more »

Submitted by (@katiebecofsky)

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Goal 2: Reduce Human Disease

Consequences of drug interactions leading to QTc prolongation

Better understand the consequences of drug interactions leading to QTc prolongation. About 1/3 of cardiac ICU patients develop QT prolongation and about 45% receive drugs that are possibly contributing to this problem. The full spectrum of contributors and causes, as well as the patient-centered and health-system-centered clinical outcomes, are not known.

Submitted by (@greg.martin)

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Goal 1: Promote Human Health

Interaction of blood cells with their environment

It is beginning to be known that malignant cells interact with neighboring cells and the course of their malignancy is directed by those cells. It is also known that transplanted stem cells interact with nearby cells and acquire direction of maturation and cell type from those cells. In my experience in unpublished work, the nature of the materials that leukocytes and monocytes have encountered during their apheresis ...more »

Submitted by (@nhlbiforumadministrator1)

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