Lung transplantation as a cure for terminal lung disease has seen little improvement in outcomes for more than 20 years. The field remains highly challenging, in part, because of an absence of robust animal models which are technically- feasible and reproducible across centers. Further, models have limited relevance to clinical (chronic) airway remodeling, the leading problem in pulmonary allografts. In the absence of ...more »
What is the relationship of ChILD disorders to more common childhood respiratory diseases?
What is the role of lung stem/progenitor cells in disease?
Which diseases involve stem cell defects?
What health promotion activities/strategies maximize lung health across the lifespan? Does maximizing growth and development of the lung promote lung health across the lifespan?
Do the non-pharmacological interventions of pulmonary rehabilitation and supplemental oxygen for exertional hypoxemia improve quality of life and functional status in patients with chronic fibrotic ILD?
Can a multipronged approach to reversing/repairing scar tissue in pulmonary fibrosis be deployed as soon as possible?
More emphasis must be placed on systemic manifestations and co‐morbidities of chronic lung disease such as depression, oral disease and heart disease.
What stimuli cause developmental processes to be reactivated in the lung?
Does "goal-targeted" therapy (with adjustments/additional therapy, if certain "goals" are not achieved) improve quality of life, functional status, and survival in patients with pulmonary arterial hypertension? Trials of therapies for hepatopulmonary syndrome.
Non-invasive measurement of transcutaneous carboxyhemoglobin (SpCO) by CO-oximetry has been shown to reflect disease activity in asthma, allergic rhinitis, Staphylococcal pneumonia/sepsis and to correlate positively with lung function in cystic fibrosis. Given published studies of heme oxygenase activity in these diseases as a reflection of oxidant or inflammatory activity, does measurement of SpCO reflect endogenous ...more »
How does insufficient sleep impair hormonal, cellular, and tissues barriers mediating lung immunity and risk of lung infection?
What is the relationship between exacerbations and progression of chronic lung diseases?