Goal 2: Reduce Human Disease

Defining percision medicine based on biological signatures

What are the unique bio-informatics time-series signatures that identify health, disease, response to therappy and can predict impending deterioraiton and select correct therapes base don individual patient performance characteristics.

Submitted by (@pinskymr)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Use machine learnign principles to data mine complex biological time series signals to define patterns uniquely characterizing health, disease, improvement in response to therapy and the lack thereof.

Feasibility and challenges of addressing this CQ or CC :

Need high quality time series data linked to low dimensional demographic data and treatment records to create a library of similar experiences defining cohorts.

Name of idea submitter and other team members who worked on this idea : HIPPA compliant data sharing across institutions

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4 net votes
13 up votes
9 down votes
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Goal 1: Promote Human Health

New technologies for Personalized health monitoring: too much or not enough

The development of personalized medicine and the increasing amount of information extracted from individual and patients throughout their life is expected to growth significantly. Multiple types of physiological sensors are currently embedded in everyday-life objects and yet their clinical value and their potential to improve health care is not well defined. It seems fundamental that the NIH develops a core research group/ ...more »

Submitted by (@heartjpc)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

The impact of this compelling question would promote the development of the right technologies for monitoring physiological signals at long-term. Also, this question should be addressed in collaboration with other federal agencies and institutes such as the NSF and the FDA. Both these agencies are currently supporting and reviewing new-long term technologies but the understanding of the impact of these novel techniques remains to be studied.

Feasibility and challenges of addressing this CQ or CC :

none

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5 net votes
13 up votes
8 down votes
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Goal 1: Promote Human Health

Establishing A Mobil Health Apps Monitoring Program

The recent Manhattan Research survey noted the increasing proliferation of health monitoring apps, which are accessible on mobile devices. Some experts believe that there are more than 40,000 of them already available. They mostly deal with wellness and fitness. The quality is very uneven and there is uncertainty among physicians which ones should be recommended to their patients.

Submitted by (@vlady.rozenbaum)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

A recent commentary in JAMA indicated a need for an independent or a government body to review and certify apps. That would be helpful to patients, particularly those suffering from chronic diseases. Very interesting discussion of this topic was published last October in Medical Economics.

Feasibility and challenges of addressing this CQ or CC :

Considering the fact that the number of physicians using apps continually increases, soliciting information on their experiences should not add an undue burden. Physicians will report their experiences and a quarterly assessment of the collected data will provide the expected reassurances to physicians and patients.

Name of idea submitter and other team members who worked on this idea : COPD-ALERT

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27 net votes
40 up votes
13 down votes
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Goal 1: Promote Human Health

Continuous blood pressure and outcomes monitoring

Currently technology exists for continuous, non-invasive, insertable (not breaking any skin), blood pressure monitoring. At the same time micro-vascular health and whole body inflammatory response can be monitored continuously. The challenge is for the integration of these technologies into a simple device so we can begin to produce long term data on genetic and environmental influences on outcomes.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Blood pressure monitoring via a pressure cuff has been shown to miss many of the problems with elevated blood pressure (e.g. morning surge, normotensive salt sensitivity). Continuous monitoring of blood pressure while measuring micro-capillary health will enable feedback control of the inflammatory events surrounding hypertension, salt sensitivity and related diseases.

Feasibility and challenges of addressing this CQ or CC :

At least three companies are producing research grade products for wearable continuous blood pressure monitoring. The Qualcomm X Prize has yielded several technologies that could continuously monitor microvascular health (e.g. inflammation). We have developed a genetically driven decision tree that will enable physicians can classify their patients into one of 6 cardiovascular types. Each type has a personalized therapy, many of which rely on dietary instead of pharmaceutical treatment. Thus, we need to move cardiovascular diagnosis and therapies into the modern wellness age of medicine.

Name of idea submitter and other team members who worked on this idea : Robin A Felder

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-1 net votes
11 up votes
12 down votes
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Goal 2: Reduce Human Disease

Predicting and monitoring atherosclerosis progression and vulnerable plaque

How to develop novel methods for predicting and monitoring atherosclerosis progression and vulnerable plaque including biomarkers and imaging?

Submitted by (@societyforvascularsurgery)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : Society for Vascular Surgery

Voting

3 net votes
4 up votes
1 down votes
Active