Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Greater reliance on stronger observational study designs when true RCTs are not an option

With some notable exceptions, the space in between OATs and pure RCEs is seen, at least in obesity research, as a void. Such a constrained view inappropriately lumps together valid evidence from strong, non-randomized designs with evidence from weak designs that permit little causal inference. There are additional methods occupying that intermediary space of strength of causal inference. If we can encourage the use of ...more »

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Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Severe obesity prevention in pediatric and community settings

What novel lifestyle and behavioral modification therapies are needed to prevent or treat youth with severe obesity (>99th percentile for BMI) versus those who are overweight?

 

Can we harness ongoing registries such as POWER (Pediatric Obesity Weight Evaluation Registry) in pediatric primary care (PC) settings to implement novel trials that would link PC and community settings to prevent severe obesity in youth?

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Goal 1: Promote Human Health

Submitted by (@rpate0)

Prevention of Obesity

What are the behavioral factors that predispose to excessive weight gain and development of obesity? And, which intervention strategies can effectively prevent excessive weight gain and obesity? NHLBI, other NIH institutes and the society at-large have invested heavily in research and clinical practice aimed at treatment of obesity (i.e, weight loss in those who are already overweight). However, much less research ...more »

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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator)

Move toward more probative research

As some of us described in a recent publication, in the fields of nutrition and obesity, and perhaps in other fields as well, there is often a great deal of research which uses up resources, investigator time, journal pages, and attention span for questions that do not advance the field. We call for scientists, reviewers, and funding decision makers to collectively ask much more rigorously, "How will this proposed study ...more »

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Goal 3: Advance Translational Research

Submitted by (@nhlbiforumadministrator1)

Natural Experiments and Obesity

How can approaches, such as natural experiments, be used to capture the evolution and impact of policies/environmental change that are related to obesity? There needs to be a mechanism that can quickly support the funding of natural experiment research. For instance, NIDDK and NICHD participate in a rapid response PAR that funds natural experiments in a timely manner. It only takes about 4 months from when the application ...more »

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Goal 2: Reduce Human Disease

Submitted by (@anna.adachimejia)

Design interventions to improve sleep hygiene

Inadequate sleep is associated with risk of obesity. Electronic media devices interfere with our ability to sleep well - they delay sleep, interrupt sleep, and affect sleep quality. However these devices are addictive and ubiquitous. Can we develop interventions to help people obtain adequate sleep?

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Goal 2: Reduce Human Disease

Submitted by (@kerstilinask)

Environmental induction of congenital heart defects and finding means of prevention

Congenital heart defects (CHDs) continue to be the leading cause of death among all infants with birth defects. It is reported that approximately 10% of cardiac congenital anomalies have a genetic basis. An equal percentage, or ~10%, is due to environmental factors. For ~60% the etiology is unknown and considered to have a multifactorial basis, eg, environmental agents having a role against a specific genetic background, ...more »

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Goal 1: Promote Human Health

Submitted by (@klk370)

Basic understanding on the mechanisms of overeating

We have an in depth understanding of the effects nutrients and diet have on the development of chronic disease, yet very little research funding has gone to understanding the basic mechanisms of eating behavior and how to successful change diet. There are currently no study sections at NIH that specialize in nutrition and/or human eating behavior, and therefore proposals in this subject area get farmed out to other study ...more »

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Goal 1: Promote Human Health

Submitted by (@victor.j.stevens)

dose-response relationship for behavioral treatment of obesity

As a member of the NHLBI panel updating the obesity treatment guidelines, it was clear that there has not been much systematic work on the relationship between the frequency of intervention contacts and the short and long-term effects on weight change and maintenance of weight change. The general finding that more frequent contacts with professional weight loss counselors, and a longer series of contacts, are more effective, ...more »

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