Goal 3: Advance Translational Research

Submitted by (@hgussin)

Use of symptoms vs spirometry in increasing patient and provider adherence to guidelines

What is the comparative effectiveness of using symptoms vs. spirometry in increasing patient and provider adherence to COPD treatment guidelines and patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations)?

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Goal 2: Reduce Human Disease

Submitted by (@skrenrich)

Patient Registries

Researchers at academic institutions, research foundations, and industry are poorly managing clinical data about patients they treat and enroll in clinical trials. A better coordinated patient registry effort related to heart, lung, and blood disease patients would yield long term benefits for clinical research and clinical care improvement.

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5 net votes
8 up votes
3 down votes
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Goal 3: Advance Translational Research

Submitted by (@jimandmarynelson)

Brief vs. teach-to-goal interventions in teaching patients with COPD to use inhalers

What is the comparative effectiveness of brief interventions to teach patients respiratory inhaler use (e.g., verbal and written instructions) vs. teach-to-goal interventions (brief interventions plus demonstration of correct technique, patient teach-back, feedback, and repeat instruction if needed) on respiratory inhaler technique and patient-reported outcomes (symptom frequency, activities of daily living, quality of ...more »

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13 net votes
16 up votes
3 down votes
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Goal 3: Advance Translational Research

Submitted by (@amutso)

The effect of continuous LTOT in COPD targeting fixed oxygen flow rates vs. oxygen saturation on patient-reported outcomes

What is the comparative effectiveness of prescribing continuous LTOT in COPD that targets fixed oxygen flow rates vs. oxygen saturation on patient-reported outcomes (symptom frequency, activities of daily living, quality of life, sleep quality, exacerbations)?

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13 net votes
16 up votes
3 down votes
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Goal 2: Reduce Human Disease

Submitted by (@nma120)

Understanding of chronobiological systems

We know that all life functions are based on circadian and other rhythms; chronobiological systems are interdependent in intricate ways. Disturbances and disorders in one part of a system may affect other vital systems in unexpected but far-reaching ways. Many aspects of circadian rhythms and sleep-wake regulation in normal, healthy humans have been charted. Much of the knowledge thus gained is assumed to be valid also ...more »

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1 net vote
1 up votes
0 down votes
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Goal 3: Advance Translational Research

Submitted by (@gacdk0)

Definitive Evidence of the Effectiveness of Pulmonary Rehabilitation

What is the clinical effectiveness of pulmonary rehabilitation in reducing hospital admissions and readmissions, improving health outcomes such as exercise tolerance and dyspnea, and positively impacting patient centered outcomes. Does this effectiveness vary based on the types of settings rehab is conducted in, urban vs rural environments, the components to the program, the timing of the program and the overall support ...more »

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9 net votes
12 up votes
3 down votes
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Goal 4: Develop Workforce and Resources

Submitted by (@docew0)

Creating research infrastructure through supporting the development of biorepositories and registries for rare lung diseases

Progress in rare lung diseases, such as interstitial lung diseases, has been hampered by a lack of patient-derived samples in large enough quantities or high-enough quality for systematic study. This is due to the inability of individual centers to recruit enough patients, and because of the varied samples each center obtains. Collecting, preparing, and storing such samples is not fundable by the NHLBI because it is not ...more »

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-1 net votes
11 up votes
12 down votes
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