Goal 2: Reduce Human Disease

National AICD and resynchronization therapy prospective registry

Emerging data suggest underutilization and variation of care in heart failure patients with ICD defibrillator therapy. Furthermore, there is a lack of data about those who benefit and those who will not benefit, including the role of gender, age and CHF morphology (phenotype).

 

creation of reliable and validated data entered into a registry with cases and controls

Submitted by (@nhlbiforumadministrator1)

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Goal 2: Reduce Human Disease

What are the biological consequences of sleep loss or disruption and how can they best be avoided?

Arousals in obstructive sleep apena (OSA) are life saving, but the associated disruption of sleep is now thought to cause cognitive impairment, increased risk of high blood pressure and atherosclerosis, as well as glucose intolerance and metabolic syndrome. The mechanisms for these downstream effects, however, are not well understood. Can these specific pathophysiological mechanisms be identified, and can ways for mitigating ...more »

Submitted by (@csaper)

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Goal 2: Reduce Human Disease

Heterogeneity in Asthma Phenotypes

As the current chair of the Research and Training Division, I would like to convey that the AAAAI membership would like the NHLBI to consider the following in the development of its strategic plan: Asthma appears to be due to heterogenous etiologies.  To better characterize the various phenotypes and potential etiologies, it would be important to create more epidemiologic and biomarker focused databases, which could ...more »

Submitted by (@wheeze)

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Goal 4: Develop Workforce and Resources

Strategic Visioning Initiative is just a beginning: it needs a mechanism for implementation

NHLBI Strategic Visioning Initiative is a good idea. You have received a score of useful suggestions from Academia and business. But like and good idea, it needs someone to follow through. Otherwise your new beautiful plans for cardiovascular research may die without a significant impact.

Submitted by (@soldatovn.humgenex)

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Goal 4: Develop Workforce and Resources

DEVELOPMENT AND SUPPORT FOR APHERESIS MEDICINE INVESTIGATORS

The apheresis medicine encompasses treatment of numerous diseases many of which are directly related to blood, lung and heart. However, there are very limited opportunities for training young investigators in basic and translational research related to Apheresis Medicine. There is a need to promote Apheresis Medicine as a viable field of research for junior and established investigators. The influx of well-trained junior ...more »

Submitted by (@zbigniew.m.szczepiorkowski)

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