Strategic Goal: Goal 2: Reduce Human Disease

Image Repository

There is a need to digitize, remove identifiers, and archive, and catalog physical images, and to promote their use in clinical investigations.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Enable leveraging existing resources and possible re-purposing of existing resources to address a wide variety of research questions.

 

This is a cross-study, cross-NHLBI, and even cross-NIH or beyond, need.

Feasibility and challenges of addressing this CQ or CC :

Digitized imaging data files are enormous. Advances in data storage, with corresponding decreases in cost, have enabled storage of these files. For some types of images, data format standards have also arisen.

Many studies have collected data using a wide variety of imaging technologies. While the extracted data have been utilized in analyses and incorporated into shared data resources, additional research could be done on the original images.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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12 up votes
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Strategic Goal: Goal 2: Reduce Human Disease

Lung Transplantation

As in other solid organ transplants, adherence to the medical regimen after adult and pediatric lung transplantation is less than ideal and contributes to poor health outcomes. a) How can we improve the prediction of which lung transplant recipients are at greatest risk for nonadherence? b) What are the most efficient and effective ways of assessing nonadherence in the clinical setting? c) Conduct clinical trials of ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : ATS Member

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1 net vote
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Strategic Goal: Goal 3: Advance Translational Research

Telemonitoring and COPD Exacerbations

What is the effectiveness of the telemonitoring system to detect and trigger treatment for COPD exacerbations?

Submitted by (@abryan)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

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8 up votes
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Strategic Goal: Goal 2: Reduce Human Disease

what endogenous anti-inflammatory mechanisms can improve vascular diseases

the role of pro-inflammatory mechanisms of vascular disease are well characterized, but we know little about potentially protective endogenous anti-inflammatory mechanisms.

Submitted by (@mautieri)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

this will identify new therapy or targets of therapy to improve our understanding of most vascular disease and lead to improved human health.

Feasibility and challenges of addressing this CQ or CC :

this is quite feasible; if we know so many pro-inflammatory mechanisms which for years we have tried to reduce or prevent, we can just as easily identify endogenous anti-inflammatory mechanisms that we can identify and enhance.

Name of idea submitter and other team members who worked on this idea : Mike Autieri

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18 up votes
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Strategic Goal: Goal 2: Reduce Human Disease

Impact of intrauterine environment on obesity

How does maternal obesity before or during pregnancy affect the intrauterine environment and increase the risk of overweight/obesity in the offspring?

How does maternal dietary intake during pregnancy impact weight in the offspring?

What types of interventions are most effective for preventing excessive gestational weight gain among high risk groups?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Developing effective interventions during pregnancy can help reduce the risk of obesity in the offspring and mother.

Feasibility and challenges of addressing this CQ or CC :

Addressing how the intrauterine environment impacts obesity is feasible because there is already existing preliminary data that shows pregnancy can have an impact on obesity in offspring. More work needs to be done to better understand the mechanism and how best to intervene.

There is emerging evidence that the intrauterine environment can have an impact on obesity.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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33 net votes
66 up votes
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Strategic Goal: Goal 1: Promote Human Health

Transformative Impact of Proteomics

The proteomics field has dramatically progressed over the past 20 years, with advancements and improvements in experimental designs and sample preparation protocols, as well as mass spectrometry equipment, approaches, and analysis. This has resulted in substantial forward progress towards a proteomic pipeline to establish cause and effect mechanisms of cardiovascular disease. There is a need for CV proteomics that resolve ...more »

Submitted by (@mllindsey)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

The necessary tools have been assembled, and managing implementation will reduce the time required for completion of larger scale projects.

Feasibility and challenges of addressing this CQ or CC :

high feasibility; the challenge will be managing communication across groups to maximize impact

Name of idea submitter and other team members who worked on this idea : Merry Lindsey

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196 net votes
234 up votes
38 down votes
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Strategic Goal: Goal 1: Promote Human Health

Would unconditional basic income improve people's health & ease poverty better than conventional welfare programs?

Here's an article on the "Mincome" program which Canada tested in the 1970's in a small town: http://www.dominionpaper.ca/articles/4100 It had many positive effects on people's lives and health. Quotes: 'In the period that Mincome was administered, hospital visits dropped 8.5 per cent.' [...] '“When you walk around a hospital, it's pretty clear that a lot of the time what we're treating are the consequences of poverty,” ...more »

Submitted by (@apollia112)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

See comments

Feasibility and challenges of addressing this CQ or CC :

See comments

Name of idea submitter and other team members who worked on this idea : Apollia

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Strategic Goal: Goal 2: Reduce Human Disease

Hypertension Treatment Metrics

What goal and what should be the threshold to initiate hypertension treatment?

Is a risk based approach most relevant?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

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14 up votes
20 down votes
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Strategic Goal: Goal 3: Advance Translational Research

What is the optimal way to improve cardiac arrest resuscitation?

Sudden Death from cardiac arrest and gaps in knowledge of emergency cardiovascular care are the #1 killer of more than 400,000 Americans each year. This epidemic of death and disability is largely ignored and underfunded by NIH and all funding agencies and kills more than HIV, Cancer, Diabetes, and infectious diseases. There is no national registry of cardiac arrest, no mandatory reporting, and poor funding for both fundamental, ...more »

Submitted by (@nadkarni)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Answering this question will save more lives and quality of life-years than all other infectious diseases in North America. The potential interventions are well developed and we need more fundamental, translational and implementation science to impact this most significant problem. An upcoming IOM report on needless deaths resulting from cardiac arrest is anticipated to be published in 2015.

Feasibility and challenges of addressing this CQ or CC :

Very feasible, just needs support and funding. A call to arms is being issued by the American Heart Association and Institute of Medicine. The roadmap is outlined, and all we need to do is follow the roadmap.

Name of idea submitter and other team members who worked on this idea : Vinay Nadkarni MD

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37 up votes
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Strategic Goal: Goal 1: Promote Human Health

Improve understanding of cardiometabolic health in Asian Americans

We are only now beginning to recognize that certain Asian American subpopulations are at high risk for cardiometabolic (CM) disorders thanks to recent ethnicity-specific studies (e.g., MASALA study). For the most part, however, our understanding of CM risk in Asian Americans is based on aggregated data. Further, a perception remains that other, understudied groups (e.g., Chinese Americans) are at low risk because of their ...more »

Submitted by (@mtseng)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Decisions regarding public health programming, education, and resources are based on an assumed understanding of cardiometabolic health/risk in Asian American populations rather than on existing, high quality, epidemiologic evidence. Addressing this CQ would provide necessary surveillance/monitoring information for appropriate targeting of resources and it would point to important contextual or individual level determinants to be targeted for programming or intervention.

Feasibility and challenges of addressing this CQ or CC :

This CQ is entirely feasible using established epidemiologic methods although new recruitment methodologies might be necessary to reach broad, population-based samples. The primary obstacle is in recognizing this as a significant public health issue.

Name of idea submitter and other team members who worked on this idea : Marilyn Tseng

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5 up votes
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Strategic Goal: Goal 4: Develop Workforce and Resources

Increasing Public-Private Partnerships

Given the difficulties of obtaining funding, especially among young investigators, NHLBI should consider public-private partnerships to increase the pool of available opportunities.

Submitted by (@golan0)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

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Strategic Goal: Goal 3: Advance Translational Research

High Quality COPD care coordination

What factors are associated with high quality care coordination in patients with COPD?

Submitted by (@kdeit1946)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Patients would benefit from high quality care coordination; costs to insurance companies would probably decrease as would hospitalizations; would result in better quality of life for patients.

Feasibility and challenges of addressing this CQ or CC :

All providers must be willing to share information; PCP's must be willing to screen for COPD and make referrals when indicated; would be a challenge in very rural areas with very few resources.

Name of idea submitter and other team members who worked on this idea : Karen Deitemeyer, COPD Foundation State Captain Program

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16 net votes
18 up votes
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