Goal 2: Reduce Human Disease

Resistance to smoking-related disease

What are the factors that determine resistance to smoking-related heart and lung disease?

 

What are the common pathways amenable to intervention to prevent smoking related to heart and lung disease?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

-2 net votes
7 up votes
9 down votes
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Goal 4: Develop Workforce and Resources

Challenges in attracting students to research careers

What are the best methods for NHLBI to contribute to reforms that make careers more attractive to people from disadvantaged backgrounds?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

It would potentially increase the diversity of the biomedical research workforce.

Feasibility and challenges of addressing this CQ or CC :

Yes, it is feasible, but systemic reform is always challenging.

Pursuing a biomedical research career often involves 5–8 years of graduate education earning very low income (and suffering high opportunity costs), post-doc positions that pay less than some entry-level jobs with an undergraduate degree, and significant career uncertainty (as revealed by the work of Michael Teitelbaum (http://press.princeton.edu/titles/10208.html) and other scholars who have studied the scientific workforce). An undergraduate degree holder contemplating alternative options, such as simply taking a job or pursuing an MBA or a clinical career (MD, PA, physical therapist, etc.), would likely recognize that obtaining a PhD in biomedical science, compared to these alternative options, involves significantly lower lifetime earnings (http://www.ncbi.nlm.nih.gov/books/NBK36349/), more deferment of adult milestones, and less career stability. Students from disadvantaged backgrounds may be especially wary of careers that present continued financial struggle and uncertainty. Proposals to modestly increase post-doc pay (from its current $42,000) and to favor training grants over research grants (http://www.pnas.org/content/111/16/5773.full.pdf+html) seem unlikely to change the financial calculus: that pursuing these careers is often a bad financial deal.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

16 net votes
33 up votes
17 down votes
Active

Goal 2: Reduce Human Disease

Understanding Glymphatic Pathways and Waste Clearance abnormalities in brain disease

Cerbrospinal fluid flow and waste clearance through glyphatic pathways are likely to be important in numerous brain diseases including such devastating diseases such as alzheimer's , parkinson's, stroke and migraine. However, relatively little is known about the brain's waste clearance mechanisms, and how failure in these systems may underlie brain disease. Build up of proteins and calcification have been shown to ...more »

Submitted by (@ceci00)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Studies on the etiology of migraine, stroke, motor disturbance, hydrocephalus, mental health and alzheimer's and numerous other brain diseases have overlooked the possible dysfuncton of brain waste clearance mechanisms. Similar to the case for renal failure, build up of toxic wastes in the brain may impact all aspects of brain health. A dedicated effort in understanding how the brain clears waste and the conditions that cause this to be imparied may open completely new avenues for treatment of debiltating brain diseases.

Feasibility and challenges of addressing this CQ or CC :

Very little is known about the choroid plexus and other CSF generating tissues, the regulation of CSF compostioin and its flow through newly discovered glymphatic pathways. Furthermore, the challenge is determining whether deficiencies of these processes affect brain health. New technologies allow us to visualize the brain and CSF as never below, and can help us to make these connections. Furthermore, our advancing understanding of brain anatomy makes further investigation in this area timely and feasible.

Name of idea submitter and other team members who worked on this idea : Ceci Giachelli

Voting

3 net votes
3 up votes
0 down votes
Active

Goal 2: Reduce Human Disease

To build on the information obtained from population based and epidemiological studies

What is the basis for relative resistance or vulnerabilities to obesity or related adverse health effects observed in various segments of population?

Submitted by (@mturner)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Population based and epidemiological studies have identified segments of population that are resistant or susceptible to obesity and cardiovascular risks. Continued research is needed to identify additional such populations and their differences. Moreover, the next phase of research could be to understand the basis for this relative resistance or vulnerabilities, and exploit the information to improve obesity and cardiovascular disease risk at a community level.

Feasibility and challenges of addressing this CQ or CC :

Moving forward, strategies are needed that don’t yield only incremental benefits, but instead emphasize ‘high risk, high impact’ research to some extent. Given the enormous public health crisis obesity represents we urge continued support of basic, clinical, population, and translational obesity research.

Name of idea submitter and other team members who worked on this idea : The Obesity Society

Voting

7 net votes
13 up votes
6 down votes
Active

Goal 1: Promote Human Health

What is the potential effect of the burden of COPD on the US workforce?

COPD currently affects approximately 25 million individuals in the US alone, many of whom are of working age, according to the most recent BFRSS data. Many of those people are encouraged by their doctors or families to apply for disability and receive it, even though there are still jobs they could do. This is going to have an impact on business and industry as these people who are at the peak of their careers leave. ...more »

Submitted by (@jmrommes)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

I think if this question were answered and that industry understood the impact of COPD on the potential workforce going forward, there would be significant interest from business and industry to do several things:

prevent COPD; develop accommodations that would allow people with COPD to continue to work; reduce the burden to both industry and individuals with COPD by allowing them to continue to work and produce until planned retirement.

Feasibility and challenges of addressing this CQ or CC :

This would not be a difficult question to answer. More difficult would be the education of both individuals and business and industry in how to accommodate people with COPD so they can continue to work until their planned retirement. Techniques and strategies could be developed, however, benefiting both business and the individual.

Name of idea submitter and other team members who worked on this idea : Jean M. Rommes

Voting

8 net votes
15 up votes
7 down votes
Active

Goal 4: Develop Workforce and Resources

Redefining success to include scientific careers other than research

How do we redefine success to include scientific careers other than research (e.g., careers in teaching, industry, government) and provide opportunities for exposure to alternative careers?

Submitted by (@nhlbiforumadministrator1)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Feasibility and challenges of addressing this CQ or CC :

Challenges:

• Redefining success

• Encouraging team based research by rewarding it and redefining success to include it

• Training programs in alternative careers in science, particularly industry

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

8 net votes
20 up votes
12 down votes
Active

Goal 2: Reduce Human Disease

Blood Pressure Recommendation

What should be the systolic blood pressure goal for pharmacological treatment, and should it vary by age or by cardiovascular disease (CVD) risk category?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Feasibility and challenges of addressing this CQ or CC :

Despite fifty years of clinical trial research and forty years of national guideline activity, important clinical questions remain under intense scientific debate. The importance of these questions are underline by the scientific consensus that hypertension is most important cardiovascular risk factor globally, in fact, more important than even tobacco use.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

-1 net votes
13 up votes
14 down votes
Active

Goal 1: Promote Human Health

Functional and high throughput screening assays

There is a need to develop functional assays and high throughput screening to develop probes and potential drug therapies. A. Functional Assays. Researchers face a challenging gap between identifying many sequence variations of potential interest and recognizing which of these variations have a direct functional effect on the physiological system of interest, as opposed to merely being associated with the actual causal ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Better tools and assays will help develop therapeutics faster and understand basic mechanisms. Improved genes-to-function screens are critical to accelerating the translation of genomic findings, by making screens of genes and variants for altered physiological function faster, cheaper, and more accurate.

Feasibility and challenges of addressing this CQ or CC :

Current technologies and recent NIH pushes for this type of research has investigators and technological advances primed to influence NHLBI disease areas.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

-1 net votes
9 up votes
10 down votes
Active

Goal 2: Reduce Human Disease

Fibrosis Care Center Network and Patient Registry

Complex diseases such as interstitial lung disease and pulmonary fibrosis requires a collaborative effort to effectively characterize, appropriately diagnose, and efficient evaluate novel therapies. Similarly, basic, translational and clinical research in this field requires the integration of clinical phenotypes with biologic specimens. We propose the expanded development of the Care Center Network and Patient Registry ...more »

Submitted by (@gcosgrove)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

The envisioned impact of an integrated Care Center Network and Patient Registry is to create a resource that:

 

• Informs the understanding of interstitial lung disease (ILD), its epidemiology and natural history;

• Assists to understand treatment patterns associated with optimal outcomes that will inform an emerging standard of care and development of treatment guidelines;

• Facilitates patient and clinician engagement in support of future prospective studies;

• Furthers study of biomarkers and predictors of disease and severity;

• Documents patient experience of living with ILD as described through patient reported outcomes (PRO) including quality of life, functioning, and symptoms;

• Generates new hypotheses and new endpoints in support of future studies;

• Increases awareness of relevant issues and needs among the immediate ILD community;

• Provides the opportunity to promote and inform policies in the larger health care community in support of those with ILD

Feasibility and challenges of addressing this CQ or CC :

With the establishment of collaborations between several partners, we initiated the PFF Care Center Network and Patient Registry in 2014. The Care Center Network and Patient Registry has since expanded to 21 centers regionally dispersed throughout the United States. The challenges of effectively and efficiently investigating the cause, care and treatment of pulmonary fibrosis are predominantly those of organization and integration of effort. Expertise is present throughout the United States. We suggest that with the continued expansion of the Care Center Network and Patient Registry, those challenges will be overcome and the focus of the fibrosis community efforts can be on diligently investigating the diseases that devastatingly affect patients. An integrated repository of well-phenotyped patients and biologic specimens is the first step in Precision Medicine for patients with interstitial lung disease and pulmonary fibrosis.

Name of idea submitter and other team members who worked on this idea : Gregory P. Cosgrove, MD, The Pulmonary Fibrosis Foundation

Voting

2 net votes
2 up votes
0 down votes
Active

Goal 1: Promote Human Health

Establishment of a permanent exercise study section

Funding opportunities explicitly for studies of exercise have not been a major NIH priority. The NHLBI has been an exception to this, but the non-existence of a true exercise study section still makes funding a challenge for individuals in the field of Exercise Science. Exercise, along with sleep and diet, is one of the pillars of health and has been shown to be highly beneficial for a number of medical conditions. However, ...more »

Submitted by (@mschubert2)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : MattS

Voting

202 net votes
290 up votes
88 down votes
Active

Goal 3: Advance Translational Research

Asthma self-management

Study patient-provider communication of asthma self-management requirements to see where gaps in communication may contribute to suboptimal self-management decisions. Examine patients’ decision-making in the home management of asymptomatic and acute. Compare different approaches to the delivery of asthma self-management education and best practices for supporting the patient as they gain competency in this area.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : American Thoracic Society

Voting

1 net vote
1 up votes
0 down votes
Active