Goal 1: Promote Human Health

To expand knowledge of the molecular and physiological mechanisms governing the normal function of heart, lung, blood, and sleep systems as essential elements for sustaining human health.

Goal 1: Promote Human Health

Study wellness instead of diseases by longitudinal follow-up of frequent and long term blood donors

Blood donors (especially young donors) in general represent healthy populations. Longitudinal follow-up of frequent and long term blood donors can be useful to establish data and sample sources for the study of wellness, instead of disease (especially for blood diseases). Not only it can be used as healthy controls, it can also be used to predict the wellness factors such as genetic variation, life style, exercise patterns, ...more »

Submitted by (@yanyunw)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Once such study is established, it can be used as a wellness model/control for many diseases and conditions. The longer we have the study, more useful it will become. This can help us to change or optimize our health care model, from treating diseases to maintain wellness.

Feasibility and challenges of addressing this CQ or CC :

This can be quite feasible as there are many frequent and long term donors. They care about others’ health as well as their own health. They are also very willing to support research. Follow-up can start from early adulthood.

 

With funding support this can be achieved.

Name of idea submitter and other team members who worked on this idea : Yanyun Wu

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Goal 1: Promote Human Health

smoking cessation in rural and special populations

We are concerned about access to smoking cessation programs in populations that are hard to reach (rural) and who have other challenges (underserved/marginalized populations including people with serious mental illness). What kind of computer-based or mobile health technologies can assist these groups?

Submitted by (@anna.adachimejia)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : Anna Adachi-Mejia for colleagues at Dartmouth

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Goal 1: Promote Human Health

Lung disease hits/triggers

What are the hits/triggers that occur early in life that predispose to lung disease later in life?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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Goal 1: Promote Human Health

Origins of early disease

Defining the origins of early disease.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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Goal 1: Promote Human Health

Genetic, epigenetic, and environmental influences on lung development.

Understanding the genetic, epigenetic, and environmental influences on lung development.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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Goal 1: Promote Human Health

Injury, regeneration and repair of the developing lung

Understanding injury, regeneration and repair of the developing lung.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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Goal 1: Promote Human Health

Understanding normal aging

Understanding normal aging

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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Goal 1: Promote Human Health

Updating level C evidence in Clinical Guidelines

Clinical Guidelines depends on good science. Despite this, only 11% of guidelines that reported level of evidence in 2009, had level of evidence A while 48% had level C. Studies have shown that recommendations based on Level of Evidence C (or their equivalence) are significantly less reliable and may be downgraded, reversed or omitted when better evidence is available. I propose a comprehensive review of ACC/AHA ...more »

Submitted by (@glancast)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Upgrading the level of evidence that recommendations are based on in clinical guidelines, will potentially improve outcomes, reduce unnecessary risk and reduce cost of all aspects of cardiovascular care.

Feasibility and challenges of addressing this CQ or CC :

There are three phases:

1) Review the current published clinical guidelines (and Appropriate Use Criteria) for recommendations relying on level of evidence of C- Very feasible.

2) Ranking impact of clinical recommendations that only have level of evidence C- Quite feasible, but will need to set up a protocol and review committee.

3) Designing and funding high priority studies: Feasible- especially if done under the umbrella of the NHLBI. The challenges will be to set up good studies that supply enough data to be useful in making recommendations based on Level of evidence A in the Guidelines.

Name of idea submitter and other team members who worked on this idea : Gilead Lancaster, MD, Associate Clinical Professor of Medicine, Yale University School of Medicine

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Goal 1: Promote Human Health

Glycans are critical for mammalian biology at a fundamental level

There is a pervasive view of glycobiology as a niche field that does not warrant significant attention. This is borne out of a profound ignorance. It is not an exaggeration to state that carbohydrates are just as important as proteins, nucleic acids, and lipids. Dismissing the impact of glycans is like stating that proteins are not very important to biology, and their importance is seen in the lethality of many mutations ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

In my opinion, glycomics is the next big frontier in mammalian biology and will be fueled by dissecting its regulation, mechanistic roles in disease, and the therapeutic potential of its manipulation.

Name of idea submitter and other team members who worked on this idea : Brian Cobb

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Goal 1: Promote Human Health

Basic research in glycobiology is urgently needed

There are two areas in which glycobiology has been very successful: technology development and disease correlation. Through efforts exemplified by the CFG, major strides in mass spectroscopy and the creation of novel technologies for probing glycan-protein interactions (e.g. glycan microarrays) have been seen. Likewise, the success of the Programs of Excellence in Glycoscience and those of us focused on disease have also ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

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If my experience as a standing member of a study section and as a PI who submits greater

than ten R01 applications for every one funded, the reason for this gap in our knowledge is not an inability to

pursue such projects, nor is it a lack of desire within the field. The reason is that these studies never make it

through study section. Why? I believe the explanation is found in the nature of glycosylation: heterogeneity.

The strong bias in modern molecular-based science is that if something is not isolatable in a pure pristine

homogeneity, it cannot be studied. Not only is this short-sighted, it fundamentally betrays the nature of biology.

Feasibility and challenges of addressing this CQ or CC :

Part of the solution for these issues is improving education in glycobiology. The other part of the solution is below:

1. Provide opportunities for R01 and individual PI-focused fundamental glycobiology studies. Promote the dissection of fundamental pathways of regulation and function within in vivo settings so that we might

begin to convert disease correlation into pathways ripe for therapeutic targeting. There is nothing to translate to the clinic without detailed knowledge of these fundamental pathways.

2. Provide opportunities to expand local expertise and infrastructure in glycosciences across the country, rather than focusing on a few centers of strength. My experience tells me that investigators outside of glycobiology are far more likely to engage a local collaborator and/or core facility to help explore a glycan-related topic than to deal with a large center in a far-off university – at which they know no one.

3. There should be a push to promote individual labs with diverse interests and systems to broaden the impact by integrating glycobiology across multiple fields, rather than on concentrating expertise in a small number of large centers.

Name of idea submitter and other team members who worked on this idea : Brian Cobb

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Goal 1: Promote Human Health

Bypass the CSR and concurrently act to help reform it

A key aspect of making any strategic plan focused upon glycoscience funding effective is the mechanisms by which grants are chosen. The problem is not the IC and making prioritized decisions; the problem is the study section ignorance and bias. Proposals that are reviewed poorly in study section out of flippancy towards glycobiology or simple lack of a critical mass of appropriate expertise never see the light of day ...more »

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Feasibility and challenges of addressing this CQ or CC :

In order to truly promote glycobiology at the NHLBI, I would suggest two action items: 1) Heavily rely upon the RFA mechanisms in which the scientific review process is internal to the NHLBI or

special emphasis panel to ensure proper representation of glycobiologists on the panel. The success of this approach can be seen in the NHLBI-funded Programs of Excellence in Glycoscience (PEG), and I would predict similar success with the nascent NIH Common Fund Initiative in Glycosciences.

2) As much as possible, place significant pressure on the CSR to integrate far more glycobiology expertise into all standing study sections. As far as I can tell, any pressure placed on the CSR from the research community has fell upon deaf ears. One glycobiologist on a panel is inadequate.

Name of idea submitter and other team members who worked on this idea : Brian Cobb

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Goal 1: Promote Human Health

How do Circulating Precursor Endothelial Cells contribute to newly formed vessels

Endothelial cells derive from cells in the bone marrow. Circulating precursor endothelial cells contribute to newly forming vessels.

Do Alk 1 and/or Endogln mutations affect the functions of these cells once they incorporate into growing vessels. These vessels then go on to form arteriovenous malformations

Submitted by (@mariannes.clancy)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : Marianne Clancy MPA, Chris Hughes PhD

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