Effect of adenotonsillectomy on behavioral and cardiovascular outcomes in children with primary snoring

Effect of adenotonsillectomy on neurocognitive and behavioral outcomes in infants and and toddlers with obstructive sleep apnea syndrome.

Effectiveness of medications for cataplexy in children.

Does treatment of sleep apnea prevent cardiovascular disease?

Long-term risk of recurrence of obstructive sleep apnea in children successfully treated with surgery during childhood.

Do patients with cardiovascular disease benefit from sleep apnea therapy?

Does alteration of sleep duration improve patient outcomes in sleep apnea?

Does treating sleep apnea benefit metabolic complications including non-alcoholic fatty liver disease?

Does treating sleep apnea benefit patients with obstructive lung disease?

The general area is that of preoperative risk management of sleep apnea patients undergoing major surgery. This field is burgeoning with clinical activity. A large amount of healthcare dollars are expended annually in order to detect sleep apnea and offer therapy that is of unproven value. Most all of the data is retrospective case series or a mixture of retrospective and prospective cohort studies. Yet, across the country, ...more »

Randomized trial of the treatment of snoring vs. no treatment.

The notion that in order to be treated with CPAP for sleep apnea you first must have a diagnostic test, which involves either a sleep laboratory or a home study, needs to be examined.

Does a protocol-based screening for commonly occurring comorbid conditions in patients with COPD (eg. CAD, CHF, depression, sleep apnea) improve management and outcomes for patients with COPD?

There is developing evidence of major individual differences in pathways to different common sleep disorders such as obstructive sleep apnea. Moreover, there is evidence of different clinical presentations of disease and different outcomes. For example, some subjects with obstructive sleep apnea who get excessive sleepiness while others do not. The latter are still at risk for other consequences of the disorder such ...more »

There is an urgent need to develop quantifiable biomarkers for acute sleep loss, chronic sleep insufficiency, circadian disruption and sleep disorders such as obstructive sleep apnea. These problems are highly prevalent but currently we do not have biomarkers to use for case identification, prognosis, or assessing response to therapy. There are currently small studies that indicate the feasibility. A recent workshop ...more »