Goal 1: Promote Human Health

Submitted by (@garobert)

Hierarchical control of cardiac excitability

Imbalances in membrane excitability underlie a broad range of cardiac arrhythmias and conduction defects. Although we now know the genes encoding almost all ion channels, we have little understanding of how the macromolecular composition and relative numbers of different channel types is achieved to exert exquisite control over membrane potential changes in time. Even minor changes in this balance can lead to sudden ...more »

Voting

1 net vote
2 up votes
1 down votes
Active

Goal 2: Reduce Human Disease

Submitted by (@pyang0)

Congential heart defects in diabetic pregnancies: a devastating reality

There is an urgent need to understand the mechanisms underlying diabetes-induced congenital heart defects (CHDs) through basic science research and biomarker identification in human maternal circulation. Majority of the current research in CHDs is related to genetic analyses; however, environmental factors contribute to the majority of human CHDs, but the underlying mechanism is unknown. There is 60 million worldwide ...more »

Voting

22 net votes
22 up votes
0 down votes
Active

Goal 1: Promote Human Health

Submitted by (@apollia112)

Would unconditional basic income improve people's health & ease poverty better than conventional welfare programs?

Here's an article on the "Mincome" program which Canada tested in the 1970's in a small town: http://www.dominionpaper.ca/articles/4100 It had many positive effects on people's lives and health. Quotes: 'In the period that Mincome was administered, hospital visits dropped 8.5 per cent.' [...] '“When you walk around a hospital, it's pretty clear that a lot of the time what we're treating are the consequences of poverty,” ...more »

Voting

0 net votes
2 up votes
2 down votes
Active

Goal 3: Advance Translational Research

Submitted by (@lungmatbio1)

Next Stage of COPD Discovery

1) Refinement of COPD subphenotypes for therapeutics, diagnostics and mechanistic interrogation. The NIH should encourage a strong focus on a) rigorous, mechanistically-reinforced definitions (chronic bronchitis, emphysema (with and without obstruction), frequent exacerbators, combined pulmonary fibrosis and emphysema) and 2) the development and optimization of animal model systems that replicate the different subphenotypes. ...more »

Voting

16 net votes
26 up votes
10 down votes
Active

Goal 2: Reduce Human Disease

Submitted by (@dkass0)

Heart Failure Therapies

We need much more support for critical basic research to understand and develop transformative therapies for this enormous health care burden. This is not simply a question of epidemiology and large multicenter population data bases. We really need hard core science. It is impossible to know where the next breakthrough will come, and setting aside funds for hot button things - stem cells, or iPS, or gene editing per ...more »

Voting

6 net votes
18 up votes
12 down votes
Active

Goal 4: Develop Workforce and Resources

Submitted by (@bmoore)

Basic and Clinical Multi-disciplinary Partnerships to Understand Lung Disease

Basic scientists and clinicians have different training and bring different perspectives to lung disease research. Additionally, mechanisms that facilitate interactions of scientists from different fields may improve communication and facilitate novel ideas for lung disease research. I would like to see a funding mechanism that encouraged such partnerships in addressing fundamental disease questions and/or treatments. ...more »

Voting

3 net votes
11 up votes
8 down votes
Active

Goal 1: Promote Human Health

Submitted by (@paulbrookes)

Adult Cardiomyocytes in Culture

So much basic cardiovascular discovery relies on cell culture models. While cardiac cell lines exist (e.g. HL-1, H9c2), these often poorly model aspects of cardiomyocyte function in-situ (e.g. contractile function, metabolism). In contrast, primary cardiomyocytes isolated from adult animals (especially mice!) are not readily amenable to culture conditions. Even if cells can be kept alive, they are often refractory to ...more »

Voting

-25 net votes
12 up votes
37 down votes
Active

Goal 4: Develop Workforce and Resources

Submitted by (@parise)

R01 funding

Unless we fix and increase the R01 funding rate, which most basic scientists depend upon, we will continue to lose outstanding scientists of all ages and not have the next generation of scientists or the numbers of currently outstanding scientists to answer any of these compelling questions and critical challenges. Related to this, much has been written about the significant failure rate of clinical trials in part due ...more »

Voting

420 net votes
435 up votes
15 down votes
Active

Goal 2: Reduce Human Disease

Submitted by (@nhlbiforumadministrator1)

Basic Research for HIV/AIDS and HLB Health and Diseases

What HIV/AIDS-related basic research can NHLBI support in the next 5-10 years to investigate the fundamental mechanisms of HIV-related heart, lung, and/or blood (HLB) diseases alone and in the context of antiretroviral therapy (ART) to improve heart, lung, and blood health outcomes in HIV infections as well as the fundamental mechanisms of hematopoietic stem cell transplantation in potential elimination or eradication ...more »

Voting

-22 net votes
14 up votes
36 down votes
Active

Goal 1: Promote Human Health

Submitted by (@nhlbiforumadministrator1)

Transforming Transplantation with RISC

What is necessary to reprogram the immune system to improve transplant outcomes of hearts, lungs, and hematopoietic cells? While NIAID is a major funder of immunology research, we are a major contributor to stem cell research. Our resources could be combined, where NIAID would support this approach for autoimmune diseases, and we would support work in tolerance for transplants. If the NCI also wants to collaborate on ...more »

Voting

-3 net votes
15 up votes
18 down votes
Active