What is the role of clock-dependent mechanisms in cell injury/repair pathways and tissue dysfunction in heart, lung, and blood pathophysiology? How are pathways involved in disease and repair affected by aging-dependent mechanisms?
Does circadian regulation modify the effects of environmental exposures (e.g., cigarette smoke, particulates, virus/bacteria, temperature, humidity, microbiome) on airway/lung remodeling and the intensity of associated epigenetic modifications?
What circadian-based strategies (e.g. timing of medication) can be applied to improve the efficacy of treatments for heart, lung, and blood diseases (e.g. hypertension, nocturnal asthma, thrombosis, obesity/diabetes)?
Does the homeostasis and health of the lung depend on circadian-coupled genomic function?