Goal 1: Promote Human Health

Origins of early disease

Defining the origins of early disease.

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

While we are fully supportive of the recent emphasis on patient‐centered outcomes and implementation science, we are also reminded of the critical importance of investigating underlying mechanisms of pulmonary, critical care and sleep disorders. Recent discoveries have created exciting progress in the areas of cystic fibrosis, pulmonary hypertension, pulmonary fibrosis, and biological therapies in asthma. Only through further efforts to elucidate underlying mechanisms are new therapeutic approaches likely to emerge. Promoting further academic‐industry interactions are likely to yield benefits, which will ultimately lead to improvements in the health of our nation.

Name of idea submitter and other team members who worked on this idea : Research Advocacy Committee, American Thoracic Society

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3 net votes
3 up votes
0 down votes
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Goal 4: Develop Workforce and Resources

Pipeline of clinician scientists

Maintaining the pipeline of clinician scientists via early and mid-career awards. Promote the development of collaborative teams.

Submitted by (@societyforvascularsurgery)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Name of idea submitter and other team members who worked on this idea : Society for Vascular Surgery

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5 net votes
6 up votes
1 down votes
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Goal 4: Develop Workforce and Resources

Would like to challenge definition of "Early Stage Investigator" for MD

Why is Early Stage Investigator defined as New Investigators who are within 10 years of completing their terminal research degree or within 10 years of completing their medical residency at the time they apply for R01 grants? This provides an unfair advantage to all PhD, general surgeons, internists, and pediatricians compared to subspecialists who complete clinical training 3-6 yrs after general training.

Submitted by (@hsiche)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

Enable the next generation to develop a research career to promote the field for the future

Feasibility and challenges of addressing this CQ or CC :

Very easy to redefine "Early Stage Investigator" to be fair to all clinicians applying for RO1. One could also give some type of advantage for short period of time to "New Investigators" now beyond 10 yrs of last training who did not have that advantage when they applied

Name of idea submitter and other team members who worked on this idea : Eileen Hsich

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-13 net votes
10 up votes
23 down votes
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Goal 2: Reduce Human Disease

Redefining asthma: origins of obstructive airways disease

Can detailed longitudinal study of lung disease in infancy/early childhood improve our understanding of the origins of obstructive airways disease, and the variation seen in asthma phenotypes and severity?

Submitted by (@pittmanj)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Asthma is, to some extent, an umbrella term that encompasses a broadly heterogenous (in severity, symptoms, and pathophysiology) group of obstructive lung diseases. This is even more true if we examine the "wheezy infant," a population defined almost exclusively by the presence of wheeze, cough, or noisy breathing with very little understanding of disease mechanism or pathophysiology, and few evidence-based treatment options. Improving our understanding of the pathophysiology of wheeze and recurrent cough in early childhood, and how these evolve into various phenotypes of "asthma," through comprehensive longitudinal study of infants and young children may lead to better endotyping of disease and improved therapeutic options, as well as the possibility of disease prevention.

Feasibility and challenges of addressing this CQ or CC :

We lack adequate biomarkers (of inflammation, structural and functional lung disease, microbiome, nutrition, etc) to investigate lung disease in infancy and early childhood. Identifying biomarkers with adequate sensitivity, and with a safety profile that allows for repeated measures in large groups of children, will be key to identifying the early childhood origins of all lung diseases.

Name of idea submitter and other team members who worked on this idea : Jessica Pittman

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-7 net votes
7 up votes
14 down votes
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Goal 3: Advance Translational Research

pre-SBIR grant mechanism

SBIR STTR programs currently offer funds to support phase 1 and phase 2 development of translation with corporate involvement. Several here have pointed out that there is need for additional NIH support of investigator initiated translation, and I concur. There is indeed need for early stage and pre-IND support. Such a program would support relatively small grants for proof-of-principle studies, pre-clinical work needed ...more »

Submitted by (@wjones7)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Critical Challenge (CC)

Details on the impact of addressing this CQ or CC :

This program would support investigator initiated translational work by supporting pre-clinical proof of principle data before involvement of a company. This would allow for better development of IP, and better developed projects would be more attractive to industry. The work would have to involve some support for project development, so access to regulatory and pharmacological resources and/or consultants to develop the idea could be supported. These could be reviewed by existing SBIR/STTR study sections and funded by the set aside funds.

 

 

 

 

 

A pipeline for investigato-initiated translational science

http://nhlbistrategicvisioning.ideascale.com/a/dtd/74967-32287

Feasibility and challenges of addressing this CQ or CC :

This might be considered a "phase 0" SBIR/STTR and as such would not need to be a large grant (say $150K). These could be used to supplement institutional grants for entrepreneur activity (which are not usually sufficient) for synergy. We have the perfect study sections that already review SBIR/STTRs and funding some of these might impact the SBIR/STTR funding levels, which are fairly generous, but not by much. Would be filling one missing link in the process of funding translation form NIH funded research.

Name of idea submitter and other team members who worked on this idea : Keith Jones

Voting

-12 net votes
10 up votes
22 down votes
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Goal 2: Reduce Human Disease

Understanding COPD Manifestations in Subjects without Overt Airflow Obstruction

What is the pathogenesis and appropriate treatment for subjects with chronic respiratory symptoms or imaging abnormalities who do not have overt airflow obstruction (and thus are not currently categorized as having COPD)?

Submitted by (@jdc000)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

COPD is currently diagnosed by spirometry, but many other individuals (primarily smokers) have respiratory symptoms and/or imaging abnormalities that suggest lung damage. Identifying subjects with pre-obstruction manifestations of COPD could lead to more effective treatment and prevention.

Feasibility and challenges of addressing this CQ or CC :

COPD subjects often develop ongoing inflammation that persists long after smoking cessation. It is unknown when this cycle of inflammation begins or what causes it.

Name of idea submitter and other team members who worked on this idea : Ed Silverman, James Crapo and the COPDGene Executive Committee

Voting

32 net votes
47 up votes
15 down votes
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Goal 1: Promote Human Health

Early Life Elements

What are the early life elements that contribute to the development of chronic lung disease? Strategies need to be developed for treatment/prevention of these elements.

Submitted by (@jdc000)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Neonatal and early life events can be essential elements for risk of development of chronic lung disease developing after age 40. Prevention of late life chronic lung disease may require that action takes place during the neonatal and childhood periods.

Feasibility and challenges of addressing this CQ or CC :

Early life and late life events can be readily studied; however, integrating cause and effect relationships between the two is challenging due to the multiple decades of time separating these events.

Name of idea submitter and other team members who worked on this idea : James Crapo

Voting

5 net votes
16 up votes
11 down votes
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Goal 3: Advance Translational Research

Investigator-Initiated Early Translation

What changes are needed to facilitate investigators independently recognizing and pursuing the early translation of their discoveries towards clinical applications through competitive peer reviewed models?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

35 net votes
44 up votes
9 down votes
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Goal 4: Develop Workforce and Resources

Increasing the pool of senior mentors

What is the best way for the mentoring effort of senior investigators to be encouraged, enhanced, and supported to develop early career investigators?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Increasing the pool of and enhancing the skills of diverse senior mentors is critical to the development of young investigators in appropriate scientific disciplines. This would promote the development of strategies to improve the quality and number of available mentors and promote an approach to mentoring that includes science, career development and research management.

Feasibility and challenges of addressing this CQ or CC :

The development of the next generation of talented new investigators who are committed to conducting research related to the mission of NHLBI can be accomplished through mechanisms that provide protected time and resources to senior investigators.

Name of idea submitter and other team members who worked on this idea : NHLBI Staff

Voting

8 net votes
27 up votes
19 down votes
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Goal 1: Promote Human Health

Critical Windows in Early Development to Maximize Lung Health

Is there a critical window of growth and development for maximizing lung function?

Submitted by (@nhlbiforumadministrator)

Is this idea a Compelling Question (CQ) or Critical Challenge (CC)? : Compelling Question (CQ)

Details on the impact of addressing this CQ or CC :

Low lung function during childhood tracks to early adulthood and contributes to early onset disease. Lung health promotion is needed, but we know little about what can enhance and protect human health during rapid phases of lung development in utero and growth postnatally to adulthood.

Feasibility and challenges of addressing this CQ or CC :

Researchers could turn their attention on healthy and “maximally” health populations (human and model organisms) to understand genetic and environmental exposures that influence lung function at upper ends of the spectrum (>2 SD from the mean).

Recent findings suggest that there is an urban-rural continuum of lung function in specific ethnic groups; and interventions with maternal dietary supplements can enhance lung function in offspring. These set the stage for further study on developing knowledge of early life events that can inform lung health promotion.

Voting

5 net votes
17 up votes
12 down votes
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